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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06618157 | ENROLLING_BY_INVITATION | NA
20 Participants

Connectomic Guided DBS for Parkinson's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2025-04-15
Completion: 2026-12-29
Conditions
Parkinson Disease Tremor Dyskinesias
Interventions
DEVICE OTHER
No Results Yet
NCT06609005 | RECRUITING | PHASE1/PHASE2
84 Participants

A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of INV-9956 in Adult Patients With Advanced Metastatic Castration Resistant Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2025-01-23
Completion: 2026-04-17
Conditions
Advanced Metastatic Castration Resistant Prostate Cancer
Interventions
DRUG
No Results Yet
NCT06608823 | RECRUITING | NA
1016 Participants

ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2025-06-18
Completion: 2026-06-30
Conditions
Aortic Regurgitation Aortic Valve Insufficiency Aortic Insufficiency
Interventions
DEVICE
No Results Yet
NCT06603077 | ACTIVE_NOT_RECRUITING | PHASE2
250 Participants

A Study to Evaluate the Efficacy and Safety of AVTX-009 in Patients With Moderate to Severe Hidradenitis Suppurativa

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-09-16
Completion: 2026-03-31
Conditions
Hidradenitis Suppurativa
Interventions
DRUG
No Results Yet
NCT06602258 | ACTIVE_NOT_RECRUITING | PHASE2
105 Participants

A Study of E2814 With Concurrent Lecanemab Treatment in Participants With Early Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-09-30
Completion: 2026-12-03
Conditions
Alzheimer's Disease
Interventions
DRUG
No Results Yet
NCT06600321 | RECRUITING | PHASE1
158 Participants

A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-12-30
Completion: 2027-09-30
Conditions
Advanced Hepatocellular Carcinoma Metastatic Hepatocellular Carcinoma
Interventions
DRUG
No Results Yet
NCT06597721 | RECRUITING | PHASE1
210 Participants

ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-11-25
Completion: 2026-06-30
Conditions
Advanced Solid Tumor
Interventions
DRUG
No Results Yet
NCT06597149 | RECRUITING | NA
30 Participants

Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2025-04-16
Completion: 2026-05-31
Conditions
Healthy
Interventions
DEVICE
No Results Yet
NCT06597019 | RECRUITING | PHASE3
51 Participants

Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-12-09
Completion: 2028-03-21
Conditions
Familial Hypercholesterolemia - Heterozygous
Interventions
DRUG
No Results Yet
NCT06592924 | RECRUITING | PHASE3
830 Participants

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2025-05-28
Completion: 2031-03-14
Conditions
Prostate Cancer (Adenocarcinoma)
Interventions
DRUG
No Results Yet
NCT06585449 | RECRUITING | PHASE1
54 Participants

A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-10-14
Completion: 2028-07-05
Conditions
Huntington's Disease
Interventions
DRUG
No Results Yet
NCT06568042 | ACTIVE_NOT_RECRUITING | PHASE2
450 Participants

Effects of LY3848575 Versus Placebo in Participants With Painful Distal Sensory Polyneuropathy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-08-22
Completion: 2026-06-30
Conditions
Neuropathic Pain Distal Sensory Polyneuropathy
Interventions
DRUG
No Results Yet
NCT06560645 | ACTIVE_NOT_RECRUITING | PHASE1
42 Participants

A Study of PRT7732, an Oral SMARCA2 Degrader, in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-11-04
Completion: 2026-10-31
Conditions
Advanced Solid Tumor Metastatic Solid Tumor Non-small Cell Lung Carcinoma SMARCA4 Mutation Esophageal Adenocarcinoma Esophageal Squamous Cell Carcinoma Gastric Adenocarcinoma Gastric Squamous Cell Carcinoma Gastroesophageal Junction Adenocarcinoma Gastroesophageal Junction Squamous Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT06551324 | RECRUITING | PHASE3
600 Participants

A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-10-21
Completion: 2025-12-17
Conditions
Metastatic Castrate Resistant Prostate Cancer (mCRPC)
Interventions
DRUG
No Results Yet
NCT06545955 | RECRUITING | PHASE3
250 Participants

A Trial to Evaluate Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade BCG Unresponsive Non-muscle Invasive Bladder Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-10-01
Completion: 2028-06-30
Conditions
Non-muscle Invasive Bladder Cancer With Carcinoma in Situ
Interventions
DRUG
No Results Yet
NCT06544291 | RECRUITING | PHASE2
147 Participants

Combined THC and CBD for OUD and Chronic Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-10-22
Completion: 2028-01-28
Conditions
Chronic Pain Opioid Use Disorder
Interventions
DRUG
No Results Yet
NCT06541145 | RECRUITING | NA
20 Participants

Bacterial Decolonization Within Dyads

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-08-21
Completion: 2026-04-30
Conditions
Bacterial Colonization
Interventions
DRUG
No Results Yet
NCT06540079 | RECRUITING | NA
220 Participants

BIOTRONIK Conduction System Pacing With the Solia Lead - Solia CSP S

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-12-18
Completion: 2025-09-18
Conditions
Sinus Node Dysfunction Bradycardia Atrioventricular Block
Interventions
DEVICE
No Results Yet
NCT06531824 | RECRUITING | PHASE3
11000 Participants

EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-08-13
Completion: 2028-08-30
Conditions
Kidney Disease, Chronic
Interventions
DRUG
No Results Yet
NCT06524544 | RECRUITING | PHASE3
320 Participants

A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan Versus Standard of Care in the Treatment of Advanced Urothelial Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2026-07-20
Completion: 2028-12-31
Conditions
Locally Advanced Urothelial Carcinoma Metastatic Urothelial Carcinoma Unresectable Urothelial Carcinoma
Interventions
PROCEDURE DRUG BIOLOGICAL OTHER
No Results Yet
NCT06519097 | ACTIVE_NOT_RECRUITING | PHASE2
4 Participants

Study of IPMN Progression Prevention With Tocotrienol (SIPP-T3)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-07-09
Completion: 2026-09-30
Conditions
Neoplasm of Pancreas IPMN, Pancreatic
Interventions
DRUG OTHER
No Results Yet
NCT06479707 | ACTIVE_NOT_RECRUITING | NA
20 Participants

Digital Literacy Intervention to Address Support, Literacy and Communication in Older Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-11-07
Completion: 2026-05-31
Conditions
Quality of Life Aging Technology Literacy
Interventions
BEHAVIORAL
No Results Yet
NCT06475989 | RECRUITING | PHASE3
264 Participants

Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-08-22
Completion: 2030-09-30
Conditions
Refractory Differentiated Thyroid Gland Carcinoma
Interventions
PROCEDURE DRUG OTHER
No Results Yet
NCT06473779 | RECRUITING | PHASE3
300 Participants

Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-09-30
Completion: 2027-06-30
Conditions
Severe Asthma
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT06465186 | ACTIVE_NOT_RECRUITING | PHASE2
80 Participants

A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-07-12
Completion: 2026-09-21
Conditions
Non-alcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis NAFLD Metabolic Dysfunction-associated Steatotic Liver Disease Metabolic Dysfunction-associated Steatohepatitis
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT06463613 | ACTIVE_NOT_RECRUITING | NA
200 Participants

Using a Novel Skin Tag Removal Device

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-06-03
Completion: 2025-11-30
Conditions
Achrochordon
Interventions
DEVICE
No Results Yet
NCT06460961 | RECRUITING | PHASE1
168 Participants

A Study of MK-6837 as a Monotherapy and Combination Therapy in Participants With Advanced/Metastatic Solid Tumors (MK-6837-001)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-07-14
Completion: 2029-07-13
Conditions
Neoplasm Metastasis
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06456346 | RECRUITING | PHASE3
300 Participants

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-07-16
Completion: 2027-09-28
Conditions
Essential Thrombocythemia
Interventions
DRUG
No Results Yet
NCT06454916 | COMPLETED | NA
79 Participants

Functional Lumen Opening With Self-Forming Magnetic Anastomosis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-10-04
Completion: 2025-06-30
Conditions
Small Bowel Anastomosis
Interventions
DEVICE
No Results Yet
NCT06449209 | ACTIVE_NOT_RECRUITING | PHASE2
110 Participants

Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-08-05
Completion: 2027-06-30
Conditions
Extensive-stage Small-cell Lung Cancer Small-cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT06448026 | RECRUITING | PHASE2
17 Participants

Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity Squamous Cell Carcinoma (OCSCC).

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-11-21
Completion: 2027-05-15
Conditions
Locally Recurrent Oral Cavity Squamous Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT06445712 | COMPLETED | NA
39 Participants

Examining the Role of Pain in the Link Between Early Childhood Adversity and Psychopathology

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-05-01
Completion: 2025-03-23
Conditions
Child Development
Interventions
BEHAVIORAL
No Results Yet
NCT06430866 | RECRUITING | PHASE3
154 Participants

Pharmacokinetic Similarity Between ABP 234 and Keytruda® (Pembrolizumab)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-09-12
Completion: 2026-12-14
Conditions
Early-stage Non-squamous Non-small Cell Lung Cancer (NSCLC)
Interventions
DRUG
No Results Yet
NCT06429436 | RECRUITING | PHASE4
4000 Participants

Vending Machine Naloxone Distribution for Your Community (VENDY)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-06-01
Completion: 2026-01-01
Conditions
Harm Reduction Naloxone Opioid Overdose
Interventions
BEHAVIORAL
No Results Yet
NCT06425302 | RECRUITING | PHASE2
90 Participants

A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-08-30
Completion: 2026-11-23
Conditions
Lymphoma, Follicular
Interventions
DRUG
No Results Yet
NCT06424288 | RECRUITING | PHASE3
6000 Participants

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-06-17
Completion: 2028-05-22
Conditions
Heart Failure
Interventions
DRUG
No Results Yet
NCT06408961 | RECRUITING
100 Participants

EVOC - EVs in Obesity and Cardiometabolic Disease

Study Type: OBSERVATIONAL
Last Updated: 2025-11-13
Start Date: 2019-02-02
Completion: 2026-05-01
Conditions
Cardiovascular Diseases
No Results Yet
NCT06403852 | COMPLETED | PHASE2
36 Participants

Investigating Near-Threshold Perception During Anesthetic Sedation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-05-10
Completion: 2025-10-03
Conditions
Propofol Anesthesia fMRI
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT06396091 | ACTIVE_NOT_RECRUITING | PHASE1
12 Participants

A Study of Zolbetuximab With Chemotherapy in Adults With Pancreatic Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2025-09-24
Completion: 2026-07-31
Conditions
Metastatic Pancreatic Adenocarcinoma
Interventions
DRUG
No Results Yet
NCT06393712 | RECRUITING | PHASE2
200 Participants

A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-05-17
Completion: 2027-07-01
Conditions
Cerebral Amyloid Angiopathy
Interventions
DRUG
No Results Yet
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