Clinical Trials
Showing trials with last updates posted in 2025.
776
Participants
A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-11-17
Completion:
2023-07-10
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG
200
Participants
A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2022-06-17
Completion:
2026-10-30
Conditions
B-Cell Non-Hodgkin Lymphoma
Relapsed B-Cell Non-Hodgkin Lymphoma
Refractory B-Cell Non-Hodgkin Lymphoma
Interventions
DRUG
No Results Yet
219
Participants
A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-07-15
Completion:
2023-11-17
Conditions
Myasthenia Gravis
Interventions
DRUG
31
Participants
Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-11-30
Completion:
2026-03-31
Conditions
Brain Metastases
HR+ Metastatic Breast Cancer
Interventions
RADIATION
DRUG
No Results Yet
25236
Participants
A Study of an Adenovirus Serotype 26 Pre-fusion Conformation-stabilized F Protein (Ad26. RSV. preF) Based Respiratory Syncytial Virus (RSV) Vaccine in the Prevention of Lower Respiratory Tract Disease in Adults Aged 60 Years and Older
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-07-21
Completion:
2023-07-21
Conditions
Respiratory Syncytial Viruses
Lower Respiratory Tract Disease
Interventions
BIOLOGICAL
14
Participants
A Study of Pembrolizumab and Radiation Therapy in People With Mesothelioma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-08-10
Completion:
2026-08-31
Conditions
Malignant Pleural Mesothelioma
Interventions
DRUG
RADIATION
No Results Yet
500
Participants
ATEMPT 2.0: Adjuvant T-DM1 vs TH
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-06-16
Completion:
2026-11-01
Conditions
Breast Cancer
HER2-positive Breast Cancer
Interventions
DRUG
No Results Yet
150
Participants
ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP)
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-13
Start Date:
2021-04-26
Completion:
2027-04-01
Conditions
Acute Hepatic Porphyria
No Results Yet
60
Participants
Treatment for Speech and Language in Primary Progressive Aphasia
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2017-07-01
Completion:
2025-08-30
Conditions
Primary Progressive Aphasia
Semantic Dementia
Semantic Memory Disorder
Logopenic Progressive Aphasia
Nonfluent Aphasia, Progressive
Aphasia
Aphasia, Progressive
Interventions
BEHAVIORAL
No Results Yet
9
Participants
Trans-abdominal Fetal Pulse Oximetry; Tissue Light Scattering and Signal Integrity
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-04-24
Completion:
2025-11-11
Conditions
Fetal Hypoxia
Interventions
DEVICE
No Results Yet
105
Participants
Zenith® Fenestrated+ Clinical Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2023-12-08
Completion:
2026-08-31
Conditions
Aortic Aneurysm, Abdominal
Juxtarenal Aortic Aneurysm
Extent IV Thoracoabdominal
Pararenal Aneurysm
Interventions
DEVICE
No Results Yet
24
Participants
Study of Safety, Tolerability and Efficacy of PBKR03 in Pediatric Subjects With Early Infantile Krabbe Disease
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2022-02-24
Completion:
2027-01-31
Conditions
Leukodystrophy, Globoid Cell
Interventions
BIOLOGICAL
No Results Yet
30
Participants
Selpercatinib Before Surgery for the Treatment of RET-Altered Thyroid Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-02-26
Completion:
2027-11-30
Conditions
Malignant Thyroid Gland Neoplasm
Poorly Differentiated Thyroid Gland Carcinoma
Recurrent Thyroid Gland Carcinoma
Thyroid Gland Anaplastic Carcinoma
Thyroid Gland Medullary Carcinoma
Thyroid Gland Papillary Carcinoma
Thyroid Gland Squamous Cell Carcinoma
Interventions
OTHER
DRUG
PROCEDURE
No Results Yet
1000
Participants
Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C Study
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-13
Start Date:
2019-11-22
Completion:
2025-12-31
Conditions
Colorectal Adenocarcinoma
Stage I Colorectal Cancer AJCC v8
Stage II Colorectal Cancer AJCC v8
Stage IIA Colorectal Cancer AJCC v8
Stage IIB Colorectal Cancer AJCC v8
Stage IIC Colorectal Cancer AJCC v8
Stage III Colorectal Cancer AJCC v8
Stage IIIA Colorectal Cancer AJCC v8
Stage IIIB Colorectal Cancer AJCC v8
Stage IIIC Colorectal Cancer AJCC v8
Stage IV Colorectal Cancer AJCC v6
Stage IVA Colorectal Cancer AJCC v8
Stage IVB Colorectal Cancer AJCC v8
Stage IVC Colorectal Cancer AJCC v8
Interventions
PROCEDURE
OTHER
No Results Yet
50
Participants
Evaluation of Multi-Tined Expandable Electrode (MEE) Efficacy and Safety in Treatment of Lumbar Facet Arthropathy by Radiofrequency Neurotomies Compared to Conservative Medical Management.
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-12-17
Completion:
2026-11-30
Conditions
Chronic Low-back Pain
Interventions
PROCEDURE
BEHAVIORAL
No Results Yet
88
Participants
Life Experiences in Adolescents and the Development of Skills
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-05-19
Completion:
2025-10-10
Conditions
Depression in Adolescence
Adverse Childhood Experiences
Interventions
BEHAVIORAL
No Results Yet
7
Participants
A Study of Darvadstrocel for Treating Complex Perianal Fistulas in Children and Teenagers With Crohn's Disease
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-06-30
Completion:
2025-05-07
Conditions
Crohn's Disease
Complex Perianal Fistula
Interventions
BIOLOGICAL
428
Participants
The Substance Abuse Treatment to HIV Care II (SAT2HIV-II) Project
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-01-14
Completion:
2023-04-30
Conditions
Substance Use
Interventions
BEHAVIORAL
244
Participants
Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-03-09
Completion:
2027-06-30
Conditions
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Interventions
DRUG
BIOLOGICAL
No Results Yet
30
Participants
Role of Diet on the Microbiome of the Digestive System
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-13
Start Date:
2020-09-29
Completion:
2026-01-01
Conditions
Colorectal Carcinoma
No Results Yet
70
Participants
Testing Lutetium Lu 177 Dotatate in Patients With Somatostatin Receptor Positive Advanced Bronchial Neuroendocrine Tumors
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2023-02-03
Completion:
2026-07-01
Conditions
Advanced Lung Neuroendocrine Tumor
Functioning Lung Neuroendocrine Tumor
Locally Advanced Lung Neuroendocrine Neoplasm
Lung Neuroendocrine Neoplasm
Lung Neuroendocrine Tumor G1
Lung Neuroendocrine Tumor G2
Metastatic Lung Neuroendocrine Neoplasm
Metastatic Lung Neuroendocrine Tumor
Non-Functioning Lung Neuroendocrine Tumor
Recurrent Lung Neuroendocrine Neoplasm
Unresectable Lung Neuroendocrine Neoplasm
Unresectable Lung Neuroendocrine Tumor
Interventions
PROCEDURE
DRUG
OTHER
No Results Yet
560
Participants
Fenofibrate for Prevention of DR Worsening
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-03-05
Completion:
2029-12-31
Conditions
Diabetic Retinopathy
Interventions
DRUG
OTHER
No Results Yet
20
Participants
Merck IIT: RRP Pembro and Lenvatinib
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2025-07-18
Completion:
2027-12-31
Conditions
Human Papilloma Virus
Recurrent Respiratory Papillomatosis
Pulmonary Disease
Interventions
DRUG
No Results Yet
360
Participants
To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-10-05
Completion:
2032-12-31
Conditions
Prostate Carcinoma
Interventions
DRUG
OTHER
No Results Yet
317
Participants
A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-03-02
Completion:
2028-04-19
Conditions
B-cell Non Hodgkin Lymphoma
Diffuse Large B Cell Lymphoma
High-grade B-cell Lymphoma
Follicular Lymphoma
Interventions
DRUG
No Results Yet
369
Participants
Still Climbin': An Intervention to Improve Coping Among Black Sexual Minority Men
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-02-09
Completion:
2025-03-20
Conditions
Discrimination, Social
Health Care Utilization
Interventions
BEHAVIORAL
230
Participants
Understanding Immunity to the Flu Vaccine in COVID-19 Patients
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-13
Start Date:
2020-10-29
Completion:
2026-04-30
Conditions
Corona Virus Infection
Flu Vaccine
Immunity
Interventions
BIOLOGICAL
No Results Yet
81938
Participants
Non-pharmacological Pain Management After Surgery
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-10-16
Completion:
2024-05-02
Conditions
Surgical Procedure, Unspecified
Interventions
BEHAVIORAL
375
Participants
A Single Arm Phase II Study of ADjuvant Endocrine Therapy, Pertuzumab, and Trastuzumab for Patients With Anatomic Stage I Hormone Receptor-positive, HER2-positive Breast Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-01-11
Completion:
2026-09-01
Conditions
HER2-positive Breast Cancer
Invasive Carcinoma of the Breast
Breast Cancer
Node Negative Breast Cancer
Micrometastasis Breast Cancer
Hormone Receptor Positive Breast Cancer
Interventions
COMBINATION_PRODUCT
DRUG
No Results Yet
6
Participants
Laser Treatment for the Improvement of Scars and Scleroderma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-06-02
Completion:
2025-04-10
Conditions
Scars
Scleroderma
Interventions
DEVICE
No Results Yet
23
Participants
Treating Primary Progressive Aphasia (PPA) Using tDCS
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-12-01
Completion:
2024-07-01
Conditions
Primary Progressive Aphasia
Interventions
DEVICE
BEHAVIORAL
1450
Participants
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-02-24
Completion:
2027-12-31
Conditions
Plasma Cell Myeloma
RISS Stage I Plasma Cell Myeloma
RISS Stage II Plasma Cell Myeloma
Interventions
DRUG
BIOLOGICAL
OTHER
No Results Yet
230
Participants
Enhancing Geriatric Pain Care
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2023-02-01
Completion:
2025-09-30
Conditions
Pain
Interventions
OTHER
No Results Yet
186
Participants
Comparison of Chemotherapy Before and After Surgery Versus After Surgery Alone for the Treatment of Gallbladder Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-02-24
Completion:
2029-06-30
Conditions
Stage II Gallbladder Cancer AJCC v8
Stage IIA Gallbladder Cancer AJCC v8
Stage IIB Gallbladder Cancer AJCC v8
Stage III Gallbladder Cancer AJCC v8
Stage IIIA Gallbladder Cancer AJCC v8
Stage IIIB Gallbladder Cancer AJCC v8
Interventions
DRUG
PROCEDURE
No Results Yet
308
Participants
A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-10-13
Completion:
2023-05-03
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG
350
Participants
A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-01-07
Completion:
2029-04-30
Conditions
Unresectable Head and Neck Squamous Cell Carcinoma
Metastatic Head and Neck Cancer
Recurrent Head and Neck Cancer
Interventions
BIOLOGICAL
No Results Yet
700
Participants
Biomarkers and Clinical Features of Metastatic Breast Cancer in Patients Treated With CDK4/6 Inhibitors
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-13
Start Date:
2020-07-03
Completion:
2030-07-03
Conditions
Anatomic Stage IV Breast Cancer AJCC v8
Metastatic Breast Carcinoma
Prognostic Stage IV Breast Cancer AJCC v8
Interventions
OTHER
No Results Yet
434
Participants
Efficacy and Safety of the Aflibercept FYB203 Biosimilar in Comparison to Eylea® in Patients With Neovascular Age-Related Macular Degeneration
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-07-21
Completion:
2022-06-23
Conditions
Neovascular Age-related Macular Degeneration
Interventions
DRUG
281
Participants
A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-01-04
Completion:
2027-07-27
Conditions
B Cell Precursor Acute Lymphoblastic Leukemia
Interventions
DRUG
No Results Yet
45
Participants
Safety Aid Reduction Treatment for PTSD Among Veterans
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2024-09-23
Completion:
2025-09-29
Conditions
Stress Disorders, Post-Traumatic
Interventions
BEHAVIORAL
No Results Yet
Showing 40 trials per page · Total 108293 trials