Clinical Trials

NCT03494569 | RECRUITING | PHASE1

36 Participants

Total Marrow and Lymphoid Irradiation, Fludarabine, and Melphalan Before Donor Stem Cell Transplant in Treating Participants With High-Risk Acute Leukemia or Myelodysplastic Syndrome

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-07-06

Completion: 2026-09-08

Conditions

Acute Lymphoblastic Leukemia Acute Lymphoblastic Leukemia in Remission Acute Myeloid Leukemia Acute Myeloid Leukemia in Remission Hematopoietic Cell Transplantation Recipient Minimal Residual Disease Myelodysplastic Syndrome Secondary Acute Myeloid Leukemia

Interventions

DRUG OTHER RADIATION

No Results Yet

NCT03491176 | ACTIVE_NOT_RECRUITING

100 Participants

Magnetic Resonance (MR) Imaging & Blood Biomarkers for Head and Neck Cancer

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2017-05-18

Completion: 2027-10-31

Conditions

Cutaneous Squamous Cell Carcinoma of the Head and Neck Healthy Subject Head and Neck Cancer

Interventions

PROCEDURE OTHER

No Results Yet

NCT03486873 | RECRUITING | PHASE3

3500 Participants

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-08-21

Completion: 2043-08-04

Conditions

Solid Tumors Hematologic Malignancies

Interventions

DRUG BIOLOGICAL

No Results Yet

NCT03481205 | RECRUITING | NA

10 Participants

Ischemic Conditioning During Air tRansport Save penUmbral Tissue

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-06-01

Completion: 2026-12-01

Conditions

Acute Stroke

Interventions

DEVICE

No Results Yet

NCT03468426 | COMPLETED | PHASE1

252 Participants

A Study to Test Different Doses of BI 836880 Combined With Ezabenlimab in Patients With Advanced Non-small Cell Lung Cancer Followed by Other Types of Advanced Solid Tumours

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-07-05

Completion: 2024-07-31

Conditions

Non-squamous, Non-Small-Cell Lung Cancer Neoplasms

Interventions

DRUG

Results Available

NCT03430037 | ENROLLING_BY_INVITATION | PHASE2

40 Participants

Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-02-06

Completion: 2026-04-30

Conditions

Frail Elderly Syndrome

Interventions

DIETARY_SUPPLEMENT DRUG

No Results Yet

NCT03423628 | RECRUITING | PHASE1

180 Participants

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-04-02

Completion: 2026-09-16

Conditions

Recurrent Glioblastoma Multiforme Primary Glioblastoma Multiforme Brain Neoplasms, Malignant Leptomeningeal Disease (LMD)

Interventions

DRUG RADIATION

No Results Yet

NCT03399799 | ACTIVE_NOT_RECRUITING | PHASE1

279 Participants

Dose Escalation Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-12-16

Completion: 2022-07-07

Conditions

Hematological Malignancies

Interventions

DRUG

No Results Yet

NCT03393884 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

130 Participants

Study of IMNN-001 (Also Known as GEN-1) With NACT for Treatment of Ovarian Cancer (OVATION 2)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-09-05

Completion: 2024-07-25

Conditions

Epithelial Ovarian Cancer Fallopian Tube Cancer Primary Peritoneal Cancer

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT03391869 | ACTIVE_NOT_RECRUITING | PHASE3

339 Participants

Nivolumab and Ipilimumab With or Without Local Consolidation Therapy in Treating Patients With Stage IV Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-12-29

Completion: 2025-12-31

Conditions

Lung Adenocarcinoma Lung Non-Small Cell Carcinoma Stage IV Lung Cancer AJCC v8

Interventions

BIOLOGICAL PROCEDURE OTHER RADIATION

No Results Yet

NCT03375619 | RECRUITING

500 Participants

Long-term Follow-up Study of Patients Receiving CAR-T Cells

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2017-12-01

Completion: 2035-01-01

Conditions

Chronic Lymphocytic Leukemia Lymphomas Non-Hodgkin's B-Cell Lymphoma, Small Lymphocytic Mantle Cell Lymphoma Central Nervous System Lymphoma Diffuse Large B Cell Lymphoma Follicular Lymphoma Burkitt Lymphoma Multiple Myeloma

Interventions

OTHER

No Results Yet

NCT03371719 | ACTIVE_NOT_RECRUITING | PHASE2

324 Participants

Radiation Therapy With or Without Apalutamide in Treating Patients With Recurrent Prostate Cancer, the BALANCE Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-06-20

Completion: 2025-03-10

Conditions

Recurrent Prostate Carcinoma Stage III Prostate Adenocarcinoma AJCC v7 Stage IV Prostate Adenocarcinoma AJCC v7

Interventions

DRUG RADIATION OTHER

No Results Yet

NCT03340506 | RECRUITING | PHASE4

100 Participants

Dabrafenib and/or Trametinib Rollover Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-12-28

Completion: 2029-12-18

Conditions

Melanoma Non Small Cell Lung Cancer Solid Tumor Rare Cancers High Grade Glioma

Interventions

DRUG

No Results Yet

NCT03301220 | ACTIVE_NOT_RECRUITING | PHASE3

390 Participants

A Study of Subcutaneous Daratumumab Versus Active Monitoring in Participants With High-Risk Smoldering Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-11-07

Completion: 2024-05-01

Conditions

Smoldering Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT03288545 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

348 Participants

A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-10-11

Completion: 2026-05-11

Conditions

Carcinoma, Transitional Cell Urinary Bladder Neoplasms Urologic Neoplasms Renal Pelvis Neoplasms Urothelial Cancer Ureteral Neoplasms Urethral Neoplasms

Interventions

DRUG

No Results Yet

NCT03281889 | ACTIVE_NOT_RECRUITING | NA

20 Participants

Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-01-04

Completion: 2027-06-30

Conditions

Brain Tumor

Interventions

RADIATION

No Results Yet

NCT03280563 | COMPLETED | PHASE1/PHASE2

144 Participants

A Study of Multiple Immunotherapy-Based Treatment Combinations in Hormone Receptor (HR)-Positive Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-12-22

Completion: 2024-09-26

Conditions

Breast Neoplasms

Interventions

DRUG

Results Available

NCT03263572 | RECRUITING | PHASE2

90 Participants

Blinatumomab, Methotrexate, Cytarabine, and Ponatinib in Treating Patients With Philadelphia Chromosome-Positive, or BCR-ABL Positive, or Relapsed/Refractory, Acute Lymphoblastic Leukemia

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-11-29

Completion: 2027-11-30

Conditions

Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive Acute Lymphoblastic Leukemia BCR-ABL1 Fusion Protein Expression Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive Philadelphia Chromosome Positive Recurrent Acute Lymphoblastic Leukemia Refractory Acute Lymphoblastic Leukemia t(9;22)

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT03259503 | COMPLETED | PHASE1

50 Participants

Olaparib and High-Dose Chemotherapy in Treating Patients With Relapsed or Refractory Lymphomas Undergoing Stem Cell Transplant

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-09-13

Completion: 2025-11-05

Conditions

Recurrent Diffuse Large B-Cell Lymphoma Recurrent T-Cell Non-Hodgkin Lymphoma Refractory Diffuse Large B-Cell Lymphoma Refractory Hodgkin Lymphoma Refractory T-Cell Non-Hodgkin Lymphoma

Interventions

DRUG PROCEDURE OTHER BIOLOGICAL

No Results Yet

NCT03228537 | ACTIVE_NOT_RECRUITING | PHASE1

28 Participants

Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-07-16

Completion: 2022-10-01

Conditions

Biphasic Mesothelioma Epithelioid Mesothelioma Stage I Pleural Malignant Mesothelioma AJCC v7 Stage IA Pleural Malignant Mesothelioma AJCC v7 Stage IB Pleural Malignant Mesothelioma AJCC v7 Stage II Pleural Malignant Mesothelioma AJCC v7 Stage III Pleural Malignant Mesothelioma AJCC v7

Interventions

DRUG PROCEDURE RADIATION

Results Available

NCT03203525 | RECRUITING | PHASE1

52 Participants

Combination Chemotherapy and Bevacizumab With the NovoTTF-100L(P) System in Treating Participants With Advanced, Recurrent, or Refractory Hepatic Metastatic Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-06-23

Completion: 2026-12-31

Conditions

Advanced Malignant Neoplasm Colorectal Carcinoma Metastatic in the Liver Metastatic Malignant Neoplasm in the Liver Refractory Malignant Neoplasm

Interventions

BIOLOGICAL DRUG PROCEDURE

No Results Yet

NCT03187951 | ACTIVE_NOT_RECRUITING | NA

152 Participants

PancFit: Multimodal Exercise During Preoperative Therapy for Pancreatic Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-06-13

Completion: 2022-12-31

Conditions

Other Disorders of Glucose Regulation and Pancreatic Internal Secretion Pancreatic Cancer

Interventions

BEHAVIORAL OTHER

No Results Yet

NCT03186898 | RECRUITING | PHASE3

186 Participants

Radiation Therapy With Protons or Photons in Treating Patients With Liver Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-01-26

Completion: 2027-06-30

Conditions

Recurrent Hepatocellular Carcinoma Stage III Hepatocellular Carcinoma AJCC v7 Unresectable Hepatocellular Carcinoma

Interventions

PROCEDURE OTHER RADIATION

No Results Yet

NCT03180268 | RECRUITING | PHASE3

163 Participants

Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-09-12

Completion: 2027-06-15

Conditions

Grade 2 Meningioma Intracranial Meningioma

Interventions

PROCEDURE OTHER RADIATION

No Results Yet

NCT03173248 | ACTIVE_NOT_RECRUITING | PHASE3

146 Participants

Study of AG-120 (Ivosidenib) vs. Placebo in Combination With Azacitidine in Participants With Previously Untreated Acute Myeloid Leukemia With an IDH1 Mutation

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-06-26

Completion: 2021-03-18

Conditions

Newly Diagnosed Acute Myeloid Leukemia (AML) Untreated AML AML Arising From Myelodysplastic Syndrome (MDS) Leukemia, Myeloid, Acute

Interventions

DRUG

Results Available

NCT03160079 | COMPLETED | PHASE1/PHASE2

16 Participants

Blinatumomab & Pembrolizumab for Adults With Relapsed/Refractory B-cell ALL With High Marrow Lymphoblasts

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-08-04

Completion: 2021-12-21

Conditions

B-Cell Acute Lymphoblastic Leukemia, Adult

Interventions

DRUG

Results Available

NCT03153475 | ACTIVE_NOT_RECRUITING | NA

400 Participants

ATTUNE Revision System in the Revision Total Knee Arthroplasty Population

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-05-30

Completion: 2029-03-31

Conditions

Revision Total Knee Arthroplasty

Interventions

DEVICE

No Results Yet

NCT03153449 | ACTIVE_NOT_RECRUITING | NA

400 Participants

ATTUNE® Revision- Complex Primary in Total Knee Arthroplasty Population

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-09-19

Completion: 2026-03-31

Conditions

Primary Knee Arthroplasty

Interventions

DEVICE

No Results Yet

NCT03145181 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

302 Participants

Dose Escalation Study of Teclistamab, a Humanized BCMA*CD3 Bispecific Antibody, in Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-05-16

Completion: 2021-11-09

Conditions

Hematological Malignancies

Interventions

DRUG

No Results Yet

NCT03142152 | RECRUITING | NA

300 Participants

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-01-01

Completion: 2026-12-31

Conditions

Functional Mitral Regurgitation Heart Failure Mitral Valve Insufficiency Heart Diseases Cardiovascular Diseases Heart Valve Diseases

Interventions

DEVICE OTHER

No Results Yet

NCT03097575 | RECRUITING | PHASE1/PHASE2

100 Participants

Bronchial NIR Image-guided Resection

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2015-01-06

Completion: 2027-01-01

Conditions

Sentinel Lymph Node

Interventions

DRUG DEVICE

No Results Yet

NCT03093909 | RECRUITING | PHASE1

44 Participants

Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-11-22

Completion: 2027-11-30

Conditions

Malignant Neoplasm of Bone and Articular Cartilage Malignant Neoplasms of Female Genital Organs Malignant Neoplasms of Independent (Primary) Multiple Sites Malignant Neoplasms of Lip Oral Cavity and Pharynx Malignant Neoplasm of Male Genital Organs Malignant Neoplasms of Mesothelial and Soft Tissue Malignant Neoplasm of Respiratory and Intrathoracic Organ Carcinoma Malignant Neoplasms of Thyroid and Other Endocrine Glands Malignant Neoplasms of Urinary Tract Melanoma and Other Malignant Neoplasms of Skin

Interventions

DRUG

No Results Yet

NCT03070886 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

612 Participants

Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-04-05

Completion: 2026-05-31

Conditions

Stage I Prostate Adenocarcinoma AJCC v7 Stage II Prostate Adenocarcinoma AJCC v7 Stage III Prostate Adenocarcinoma AJCC v7

Interventions

DRUG RADIATION OTHER

No Results Yet

NCT03066206 | ACTIVE_NOT_RECRUITING | PHASE2

93 Participants

Poziotinib in EGFR Exon 20 Mutant Advanced NSCLC

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-03-17

Completion: 2025-12-31

Conditions

EGFR Exon 20 Mutation ERBB2 Gene Mutation Recurrent Lung Non-Small Cell Carcinoma Stage IV Non-Small Cell Lung Cancer AJCC v7

Interventions

DRUG

No Results Yet

NCT03057834 | COMPLETED | NA

70 Participants

The Urinary Incontinence Treatment Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-03-01

Completion: 2020-01-29

Conditions

Urinary Incontinence Sarcopenia

Interventions

BEHAVIORAL

Results Available

NCT03038672 | ACTIVE_NOT_RECRUITING | PHASE2

54 Participants

Nivolumab With or Without Varlilumab in Treating Patients With Relapsed or Refractory Aggressive B-cell Lymphomas

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-12-21

Completion: 2023-05-26

Conditions

ALK-Positive Large B-Cell Lymphoma Diffuse Large B-Cell Lymphoma Activated B-Cell Type Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type Diffuse Large B-Cell Lymphoma, Not Otherwise Specified EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified EBV-Positive Mucocutaneous Ulcer HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements High Grade B-Cell Lymphoma, Not Otherwise Specified Intravascular Large B-Cell Lymphoma Large B-Cell Lymphoma With 11q Aberration Large B-Cell Lymphoma With IRF4 Rearrangement Plasmablastic Lymphoma Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System Primary Effusion Lymphoma Recurrent B-Cell Non-Hodgkin Lymphoma Recurrent Burkitt Lymphoma Recurrent Diffuse Large B-Cell Lymphoma Recurrent Gray-Zone Lymphoma Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements Recurrent High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements Recurrent Lymphomatoid Granulomatosis Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type Recurrent Primary Mediastinal Large B-Cell Lymphoma Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Refractory B-Cell Non-Hodgkin Lymphoma Refractory Burkitt Lymphoma Refractory Diffuse Large B-Cell Lymphoma Refractory Gray-Zone Lymphoma Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements Refractory High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type Refractory Primary Mediastinal Large B-Cell Lymphoma Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

Interventions

BIOLOGICAL DRUG

Results Available

NCT03037164 | ACTIVE_NOT_RECRUITING | PHASE3

692 Participants

INTERCEPT Blood System for RBCs Study in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-05-11

Completion: 2026-07-31

Conditions

Anemia

Interventions

DEVICE

No Results Yet

NCT03035409 | ACTIVE_NOT_RECRUITING | PHASE2

129 Participants

Anamorelin Hydrochloride, Physical Activity, and Nutritional Counseling in Decreasing Cancer-Related Fatigue in Patients With Incurable Metastatic or Recurrent Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-02-08

Completion: 2019-12-27

Conditions

Advanced Malignant Solid Neoplasm C-Reactive Protein Measurement Cancer Fatigue Metastatic Malignant Solid Neoplasm Recurrent Malignant Solid Neoplasm Weight Loss

Interventions

DRUG BEHAVIORAL OTHER

Results Available

NCT03016156 | TERMINATED | NA

1 Participants

Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-03-15

Completion: 2025-09-30

Conditions

Retinoblastoma Cataracts Infantile Glaucoma, Congenital Leucocoria

Interventions

OTHER

No Results Yet

NCT03007030 | RECRUITING | PHASE2

55 Participants

Brentuximab Vedotin in Treating Patients With CD30+ Malignant Mesothelioma That Cannot Be Removed by Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2017-04-05

Completion: 2026-05-01

Conditions

CD30-Positive Neoplastic Cells Present Malignant Mesothelioma

Interventions

DRUG OTHER

No Results Yet