Clinical Trials
80
Participants
Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2016-12-16
Completion:
2027-12-31
Conditions
Metastatic Malignant Neoplasm in the Brain
Stage IV Non-Small Cell Lung Cancer AJCC v7
Interventions
PROCEDURE
BIOLOGICAL
OTHER
RADIATION
No Results Yet
272
Participants
Vigilant ObservatIon of GlIadeL WAfer ImplaNT Registry
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-10
Start Date:
2016-04-26
Completion:
2025-06-23
Conditions
CNS Tumor
No Results Yet
20
Participants
Utilizing Holmium Laser for FURS Renal Stone Lithotripsy Comparing Stone Breaking vs. Stone Dusting Settings
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2016-02-29
Completion:
2017-01-31
Conditions
Stone Clearance
Interventions
DEVICE
60
Participants
Trametinib and Docetaxel in Treating Patients With Recurrent or Stage IV KRAS Mutation Positive Non-small Cell Lung Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2016-07-18
Completion:
2019-05-15
Conditions
KRAS Gene Mutation
Recurrent Lung Non-Small Cell Carcinoma
Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions
DRUG
OTHER
10
Participants
A Study of Haploidentical Bone Marrow Transplant for Patients With Hematologic Malignancies
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2012-09-21
Completion:
2016-05-12
Conditions
Hematologic Malignancies
Interventions
DRUG
751
Participants
Study of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants With Advanced Non-Small Cell Lung Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2016-05-24
Completion:
2026-12-31
Conditions
Non-Small-Cell Lung Cancer
Interventions
DRUG
No Results Yet
325
Participants
Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2016-06-01
Completion:
2023-06-30
Conditions
Alveolar Rhabdomyosarcoma
Botryoid-Type Embryonal Rhabdomyosarcoma
Embryonal Rhabdomyosarcoma
Rhabdomyosarcoma
Sclerosing Rhabdomyosarcoma
Spindle Cell Rhabdomyosarcoma
Interventions
DRUG
BIOLOGICAL
OTHER
RADIATION
117
Participants
Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2016-12-28
Completion:
2020-03-18
Conditions
Muscle Invasive Bladder Cancer
Interventions
DRUG
No Results Yet
1503
Participants
An Efficacy and Safety Study of JNJ-56021927 (Apalutamide) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy: ATLAS
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2015-11-19
Completion:
2026-06-30
Conditions
Prostatic Neoplasms
Interventions
DRUG
RADIATION
No Results Yet
1301
Participants
Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2015-11-10
Completion:
2023-09-15
Conditions
Clinical Stage III Cutaneous Melanoma AJCC v8
Clinical Stage IV Cutaneous Melanoma AJCC v8
Metastatic Cutaneous Melanoma
Metastatic Mucosal Melanoma
Metastatic Non-Cutaneous Melanoma
Non-Cutaneous Melanoma
Recurrent Cutaneous Melanoma
Recurrent Mucosal Melanoma
Recurrent Non-Cutaneous Melanoma
Interventions
PROCEDURE
BIOLOGICAL
OTHER
61
Participants
Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2015-09-03
Completion:
2021-04-01
Conditions
Head and Neck Squamous Cell Carcinoma
Metastatic Pancreatic Adenocarcinoma
Non-Resectable Cholangiocarcinoma
Pancreatic Adenocarcinoma
Recurrent Gallbladder Carcinoma
Recurrent Non-Small Cell Lung Carcinoma
Stage III Pancreatic Cancer
Stage IIIA Gallbladder Cancer
Stage IIIA Non-Small Cell Lung Cancer
Stage IIIB Gallbladder Cancer
Stage IIIB Non-Small Cell Lung Cancer
Stage IV Gallbladder Cancer
Stage IV Non-Small Cell Lung Cancer
Stage IV Pancreatic Cancer
Unresectable Gallbladder Carcinoma
Unresectable Pancreatic Cancer
Interventions
DRUG
OTHER
BIOLOGICAL
No Results Yet
237
Participants
Long-term Outcomes of Children With Hypoplastic Left Heart Syndrome and the Impact of Norwood Shunt Type
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-10
Start Date:
2015-06-30
Completion:
2020-10-31
Conditions
Heart Defects
32
Participants
Differing Levels of Hypoglycemia
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2015-07-31
Completion:
2026-09-30
Conditions
Hypoglycemia
Interventions
DEVICE
No Results Yet
57
Participants
Ixazomib Citrate With Gemcitabine Hydrochloride and Doxorubicin Hydrochloride in Treating Patients With Urothelial Cancer That is Metastatic or Cannot Be Removed by Surgery
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2015-07-03
Completion:
2025-12-31
Conditions
Metastatic Urothelial Carcinoma
Transitional Cell Carcinoma
Unresectable Transitional Cell Carcinoma
Interventions
DRUG
No Results Yet
166
Participants
A Study of IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2015-03-06
Completion:
2016-12-07
Conditions
Advanced Malignancies That Harbor IDHR132 Mutations
Interventions
DRUG
No Results Yet
60
Participants
Pharmacokinetic Study to Evaluate Anti-mycobacterial Activity of TMC207 in Combination With Background Regimen (BR) of Multidrug Resistant Tuberculosis (MDR-TB) Medications for Treatment of Children/Adolescents Pulmonary MDR-TB
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2016-05-03
Completion:
2027-02-11
Conditions
Multidrug-Resistant Tuberculosis
Interventions
DRUG
No Results Yet
10
Participants
Gene Therapy and Combination Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2015-11-20
Completion:
2026-09-08
Conditions
AIDS-Related Burkitt Lymphoma
AIDS-Related Diffuse Large B-cell Lymphoma
AIDS-Related Plasmablastic Lymphoma
AIDS-Related Primary Effusion Lymphoma
HIV Infection
AIDS Related Non-Hodgkin Lymphoma
Interventions
DRUG
BIOLOGICAL
No Results Yet
37
Participants
Ceritinib and Everolimus in Treating Patients With Locally Advanced or Metastatic Solid Tumors or Stage IIIB-IV Non-small Cell Lung Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2016-06-22
Completion:
2026-12-31
Conditions
ALK Positive
Locally Advanced Malignant Solid Neoplasm
Metastatic Malignant Solid Neoplasm
ROS1 Gene Rearrangement
Stage IIIB Lung Non-Small Cell Cancer AJCC v7
Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions
DRUG
OTHER
No Results Yet
81
Participants
Tamoxifen Citrate or Z-Endoxifen Hydrochloride in Treating Patients With Locally Advanced or Metastatic, Estrogen Receptor-Positive, HER2-Negative Breast Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2015-05-28
Completion:
2020-11-06
Conditions
Recurrent Breast Carcinoma
Stage III Breast Cancer AJCC v7
Stage IIIA Breast Cancer AJCC v7
Stage IIIB Breast Cancer AJCC v7
Stage IIIC Breast Cancer AJCC v7
Stage IV Breast Cancer AJCC v6 and v7
Interventions
DRUG
OTHER
2000
Participants
Germ-Line Mutations in Blood and Saliva Samples From Patients With Cancer
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-10
Start Date:
2014-09-16
Completion:
2026-09-16
Conditions
Malignant Neoplasm
Interventions
OTHER
No Results Yet
236
Participants
Phase II Study of IRD (Ixazomib, Lenalidomide, Dexamethasone) Post Autologous Stem Cell Transplantation Followed by Maintenance Ixazomib or Lenalidomide for Multiple Myeloma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2015-01-20
Completion:
2020-02-05
Conditions
Multiple Myeloma
Interventions
BIOLOGICAL
DRUG
104
Participants
Nivolumab With or Without Bevacizumab or Ipilimumab Before Surgery in Treating Patients With Metastatic Kidney Cancer That Can Be Removed by Surgery
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2014-11-25
Completion:
2025-12-31
Conditions
Clear Cell Renal Cell Carcinoma
Metastatic Kidney Carcinoma
Stage IV Renal Cell Cancer AJCC v7
Interventions
BIOLOGICAL
PROCEDURE
OTHER
No Results Yet
140
Participants
Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2014-07-11
Completion:
2019-06-30
Conditions
Alveolar Soft Part Sarcoma
Angiomatoid Fibrous Histiocytoma
Atypical Fibroxanthoma
Clear Cell Sarcoma of Soft Tissue
Epithelioid Malignant Peripheral Nerve Sheath Tumor
Epithelioid Sarcoma
Extraskeletal Myxoid Chondrosarcoma
Extraskeletal Osteosarcoma
Fibrohistiocytic Neoplasm
Fibrosarcoma
Inflammatory Myofibroblastic Tumor
Intimal Sarcoma
Leiomyosarcoma
Liposarcoma
Liver Embryonal Sarcoma
Low Grade Fibromyxoid Sarcoma
Low Grade Myofibroblastic Sarcoma
Malignant Peripheral Nerve Sheath Tumor
Malignant Skin Granular Cell Tumor
Malignant Triton Tumor
Mesenchymal Chondrosarcoma
Myxofibrosarcoma
Myxoid Chondrosarcoma
Myxoinflammatory Fibroblastic Sarcoma
Nerve Sheath Neoplasm
PEComa
Pericytic Neoplasm
Plexiform Fibrohistiocytic Tumor
Sclerosing Epithelioid Fibrosarcoma
Skin Glomus Tumor
Stage IB Soft Tissue Sarcoma AJCC v7
Stage IIB Soft Tissue Sarcoma AJCC v7
Stage III Soft Tissue Sarcoma AJCC v7
Stage IV Soft Tissue Sarcoma AJCC v7
Synovial Sarcoma
Undifferentiated High Grade Pleomorphic Sarcoma of Bone
Interventions
DRUG
RADIATION
PROCEDURE
606
Participants
Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2014-12-04
Completion:
2025-12-31
Conditions
Glioblastoma
Interventions
RADIATION
OTHER
DRUG
No Results Yet
57
Participants
A Study of JNJ-56021927 (ARN-509) and Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2014-07-09
Completion:
2016-06-27
Conditions
Prostatic Neoplasms
Metastatic Castration-Resistant Prostate Cancer
Interventions
DRUG
No Results Yet
700
Participants
Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-10
Start Date:
2014-03-11
Completion:
2028-03-30
Conditions
Epilepsy
Interventions
DEVICE
No Results Yet
488
Participants
Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2014-05-19
Completion:
2023-06-23
Conditions
Acute Lymphoblastic Leukemia
B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
Interventions
PROCEDURE
BIOLOGICAL
DRUG
80
Participants
Feasibility Study for Fibroblast Autologous Skin Grafts
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2015-01-07
Completion:
2027-12-02
Conditions
Wounds and Injuries
Interventions
BIOLOGICAL
No Results Yet
200
Participants
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2016-12-31
Completion:
2026-02-28
Conditions
Acute Myeloid Leukemia (AML)
Acute Lymphocytic Leukemia (ALL)
Chronic Myelogenous Leukemia
Plasma Cell Leukemia
Myelofibrosis
Myelodysplasia
Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma
Marginal Zone B-Cell Lymphoma
Follicular Lymphoma
Lymphoplasmacytic Lymphoma
Mantle-Cell Lymphoma
Prolymphocytic Leukemia
Diffuse Large B Cell Lymphoma
Lymphoblastic Lymphoma
Burkitt's Lymphoma
Non-Hodgkin Lymphoma
Multiple Myeloma
Interventions
DRUG
RADIATION
BIOLOGICAL
No Results Yet
39
Participants
Lenalidomide and Ibrutinib in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2013-09-24
Completion:
2024-11-06
Conditions
Recurrent Diffuse Large B-Cell Lymphoma
Recurrent Follicular Lymphoma
Recurrent Lymphoplasmacytic Lymphoma
Recurrent Mantle Cell Lymphoma
Recurrent Marginal Zone Lymphoma
Refractory Diffuse Large B-Cell Lymphoma
Refractory Follicular Lymphoma
Refractory Lymphoplasmacytic Lymphoma
Refractory Mantle Cell Lymphoma
Refractory Marginal Zone Lymphoma
Interventions
PROCEDURE
DRUG
No Results Yet
169
Participants
Ipilimumab With or Without Bevacizumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2014-01-24
Completion:
2021-10-06
Conditions
Stage IIIC Cutaneous Melanoma AJCC v7
Stage IV Cutaneous Melanoma AJCC v6 and v7
Unresectable Melanoma
Interventions
BIOLOGICAL
150
Participants
Links Between Inflammation and Cardiometabolic Diseases
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-10
Start Date:
2013-12-02
Completion:
2022-08-03
Conditions
Diabetes Mellitus
Cardiovascular Disease
Healthy Volunteer
Inflammation
Interventions
DRUG
No Results Yet
10
Participants
Islet Cell Transplant for Type 1 Diabetes
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2013-10-16
Completion:
2026-09-22
Conditions
Type 1 Diabetes Mellitus
Interventions
BIOLOGICAL
DRUG
No Results Yet
547
Participants
Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2014-01-15
Completion:
2018-08-07
Conditions
Stage I Chronic Lymphocytic Leukemia
Stage II Chronic Lymphocytic Leukemia
Stage III Chronic Lymphocytic Leukemia
Stage IV Chronic Lymphocytic Leukemia
Interventions
DRUG
PROCEDURE
OTHER
BIOLOGICAL
159
Participants
Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-10
Start Date:
2013-11-06
Completion:
2024-06-29
Conditions
Nicotine Dependence
No Results Yet
349
Participants
Rituximab and Combination Chemotherapy With or Without Lenalidomide in Treating Patients With Newly Diagnosed Stage II-IV Diffuse Large B Cell Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2013-08-27
Completion:
2020-03-26
Conditions
Ann Arbor Stage II Diffuse Large B-Cell Lymphoma
Ann Arbor Stage III Diffuse Large B-Cell Lymphoma
Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma
Interventions
DRUG
OTHER
BIOLOGICAL
15
Participants
MIBG for Refractory Neuroblastoma and Pheochromocytoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2013-12-31
Completion:
2025-10-20
Conditions
Relapsed Neuroblastoma
Metastatic Pheochromocytoma
Interventions
DRUG
PROCEDURE
No Results Yet
171
Participants
Pazopanib Hydrochloride in Treating Patients With Progressive Carcinoid Tumors
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2013-09-20
Completion:
2019-03-05
Conditions
Foregut Neuroendocrine Tumor
Hindgut Neuroendocrine Tumor
Metastatic Digestive System Neuroendocrine Tumor G1
Metastatic Neuroendocrine Tumor
Midgut Neuroendocrine Tumor G1
Neuroendocrine Tumor G2
Recurrent Digestive System Neuroendocrine Tumor G1
Regional Digestive System Neuroendocrine Tumor G1
Interventions
PROCEDURE
OTHER
DRUG
700
Participants
A Long-term Extension Study of PCI-32765 (Ibrutinib)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2013-09-09
Completion:
2026-12-31
Conditions
Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma
Mantle Cell Lymphoma
Follicular Lymphoma
Diffuse Large B-cell Lymphoma
Waldenstrom Macroglobulinemia
Chronic Graft Versus Host Disease
Interventions
DRUG
No Results Yet
1542
Participants
Survivorship of Attune Primary Total Knee Prosthesis
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-10
Start Date:
2013-02-01
Completion:
2030-02-01
Conditions
Noninflammatory Degenerative Joint Disease
Interventions
DEVICE
No Results Yet
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