Evaluation of the Effectiveness of the Ezisurg Stapling (Ezi Endo Lite) During Laparoscopic Nissen Sleeve Gastrectomy

NCT ID: NCT07344935

Last Updated: 2026-01-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

167 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-01

Study Completion Date

2025-07-01

Brief Summary

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The Nissen Sleeve technique consists of creating a gastric total fundoplication (Nissen technique) before to perform the removal of 2/3 of the stomach (SLEEVE technique), intends for decrease the rate of gastroesophageal reflux disease (GERD). This study aims to evaluate the influence of the Nissen Sleeve technique on GERD. However, the Ezisurg easyEndoTM Linear Cutting Stapler and Loading Units for Single Use were used in this study, and its safety and performance could be evaluated at the same time.

Detailed Description

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Conditions

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Gastroesophageal Reflux Disease (GERD)

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Ezisurg stapler

easyEndoTM Lite Linear Cutting Stapler (U12L60) and Loading Units (N60G) manufactured by Ezisurg

Group Type EXPERIMENTAL

Ezisurg stapler SLEEVE technique

Intervention Type PROCEDURE

The Nissen Sleeve technique consists of creating a gastric total fundoplication (Nissen technique) before to perform the removal of 2/3 of the stomach (SLEEVE technique)

Ethicon Stapler

ECHELON™ Powered Stapler and reload (GST60G) manufactured by Johnson \& Johnson.

Group Type ACTIVE_COMPARATOR

Ethicon Stapler SLEEVE technique

Intervention Type PROCEDURE

The Nissen Sleeve technique consists of creating a gastric total fundoplication (Nissen technique) before to perform the removal of 2/3 of the stomach (SLEEVE technique)

Interventions

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Ezisurg stapler SLEEVE technique

The Nissen Sleeve technique consists of creating a gastric total fundoplication (Nissen technique) before to perform the removal of 2/3 of the stomach (SLEEVE technique)

Intervention Type PROCEDURE

Ethicon Stapler SLEEVE technique

The Nissen Sleeve technique consists of creating a gastric total fundoplication (Nissen technique) before to perform the removal of 2/3 of the stomach (SLEEVE technique)

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Body Mass Index (BMI) ≥ 30 kg/m² (or BMI ≥ 27 kg/m² with at least one obesity-related comorbidity, e.g., type 2 diabetes, hypertension, dyslipidemia).
* Medically eligible for laparoscopic sleeve gastrectomy (LSG) or Nissan sleeve surgery, as determined by a multidisciplinary bariatric team (e.g., surgeon, endocrinologist, dietitian).
* Ability to understand and voluntarily sign written informed consent.
* Willingness to comply with post-operative follow-up protocols (e.g., dietary monitoring, clinical visits, laboratory tests).

Exclusion Criteria

* BMI \< 30 kg/m² (or \< 27 kg/m² without obesity-related comorbidities).
* Contraindications to laparoscopic surgery (e.g., severe abdominal adhesions, hemodynamic instability, uncorrected coagulopathy).
* History of major gastrointestinal surgery (e.g., gastric bypass, colectomy) or anatomical abnormalities precluding sleeve gastrectomy.
* Active or uncontrolled chronic diseases (e.g., end-stage renal disease, cirrhosis, metastatic cancer, severe cardiovascular disease).
* Psychiatric disorders limiting adherence to post-operative care (e.g., severe depression, psychosis, substance use disorder).
* Pregnancy or breastfeeding (or plans for pregnancy within 12 months post-surgery).
* Allergy or intolerance to surgical materials, anesthesia, or post-operative medications required for the study.
* Inability to communicate or cooperate with study procedures (e.g., language barriers, cognitive impairment).
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Montpellier

OTHER

Sponsor Role collaborator

Ezisurg Medical Co. Ltd.

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hôpital Français du Levant

Montpellier, Hérault, France

Site Status

Countries

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France

Other Identifiers

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ESM-MDR-VIII 1005B

Identifier Type: -

Identifier Source: org_study_id

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