An Extension Study to Assess the Long-term Safety and Efficacy of Hunterase (Idursulfase Beta)

NCT ID: NCT07344376

Last Updated: 2026-01-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-23

Study Completion Date

2022-12-30

Brief Summary

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The objective of this study is to assess the long-term safety and efficacy of Hunterase for approximately 1 year in subjects who completed the end of study (EOS) visit (Visit 54) tests in the Phase 3 Hunterase study and patients who received Hunterase for more than 6 months

Detailed Description

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Conditions

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MPS II Hunter Syndrome (MPS II) Hunter Syndrome Hunterase GC1111

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Phase 3 Extension study
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Hunterase

Single arm

Group Type OTHER

Hunterase

Intervention Type DRUG

0.5mg/kg weekly IV administration

Interventions

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Hunterase

0.5mg/kg weekly IV administration

Intervention Type DRUG

Other Intervention Names

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GC1111

Eligibility Criteria

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Inclusion Criteria

1. Subject diagnosed with Hunter syndrome (MPS II) who completed activities at the EOS visit (Visit 54) in the GC1111\_P3 study
2. (Subject who did not participate in the GC1111\_P3 study) Subject diagnosed with Hunter syndrome (MPS II) who received Hunterase for more than 6 months
3. (Subjects who did not participate in the GC1111\_P3 study) Males aged ≥ 5
4. Informed consent form voluntarily signed by the subject or by a legally acceptable representative
5. Subject who agrees to use contraception

Exclusion Criteria

1. Subject with hypersensitivity to any of the ingredients of the investigational product
2. Subject impossible to perform follow-up observation of the safety
3. Subject who received the treatment with another investigational product within 14 days prior to the start of study drug
4. Subject who plans to be treated with another investigational product during the study period
5. Subject who has history of tracheostomy, bone marrow transplant, or cord blood transplant
6. Any other inappropriate conditions for study participation at the investigator's discretion
Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center, Sungkyunkwan University School of Medicine

UNKNOWN

Sponsor Role collaborator

GC Biopharma Corp

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Samsung Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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GC1111_P3_Ex

Identifier Type: -

Identifier Source: org_study_id

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