Prehabilitation for Patients Diagnosed With Blood Cancer and Treated With Al-logeneic Hematopoietic Stem Cell Transplantation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

110 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-12

Study Completion Date

2032-10-12

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Seventy-five percent of patients treated with hematopoietic stem cell transplants survive one-year post-transplantation. However, this intensive treatment is associated with prolonged hospitalizations and significant deconditioning. Pathophysiological changes in skeletal muscle mass and function have notable implications for disease progression and long-term prognosis. Patients frequently report substantial rehabilitation needs, though these needs are highly individualized and fluctuate over time, with musculoskeletal dysfunction and fa-tigue being the most common barriers to prehabilitation. Furthermore, at least 35% of cancer patients are found to have inadequate daily protein intake, which may hinder improve-ments in physical performance through prehabilitation. Several recent studies have demonstrated the safety and feasibility of exercise-based prehabilitation interventions during the pre-transplant period. However, no full-scale randomized controlled trial (RCT) has been conducted to date.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Improving Self-Efficacy, Resolving Inflammaging Allo HSCT Survivors in Personal Training

NCT03609203

Allogeneic HCT Survivors

COMPLETED

Effects of Exercise on Allogeneic Stem Cell Transplant

NCT02900768

Hematological Malignancy

UNKNOWN NA

Multiphasic Prehab Allo-HSCT

NCT05649371

Leukemia

UNKNOWN NA

Fitness in Allogeneic Stem Cell Transplantation

NCT02564458

Hematopoietic Stem Cell Transplantation

COMPLETED NA

Exercise Post Bone Marrow Transplant

NCT02320942

Leukemia

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Evaluate the effectiveness of an individualized prehabilitation intervention in addition to usual care, compared to usual care alone on HRQoL, and secondary outcomes hospitalization, muscle mass and muscle function.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Allogeneic Hematopoietic Stem Cell Transplantation Recipient

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This study is a multicenter RCT. Based on a 1:1 randomization ratio, participants will be allo-cated to either usual care or usual care plus the prehabilitation intervention.

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Outcomes Assessor and statistician will be blinded

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Usual care

The usual care group will receive standard care, including physio- and occupational therapy if admitted to the hospital, and potentially referral to rehabilitation in the municipality three months after transplantation.

Group Type ACTIVE_COMPARATOR

Usual care

Intervention Type PROCEDURE

Usual care is the standard care before allogeneic hematopoietic stem cell transplantation

Usual care plus the prehabilitation intervention

The prehabilitation group will in addition to usual care receive supervised individually tailored resistance training and optimized nutritional support

Group Type EXPERIMENTAL

Resistance training

Intervention Type OTHER

Structured and supervised, group-based, resistance training 3x per week (individually tailored to the individual's capabilities)

Nutritional Support

Intervention Type DIETARY_SUPPLEMENT

Optimized dietary counseling and supplementation to optimize nutritional intake

Usual care

Intervention Type PROCEDURE

Usual care is the standard care before allogeneic hematopoietic stem cell transplantation

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Resistance training

Structured and supervised, group-based, resistance training 3x per week (individually tailored to the individual's capabilities)

Intervention Type OTHER

Nutritional Support

Optimized dietary counseling and supplementation to optimize nutritional intake

Intervention Type DIETARY_SUPPLEMENT

Usual care

Usual care is the standard care before allogeneic hematopoietic stem cell transplantation

Intervention Type PROCEDURE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Exercise Prehabilitation Prehabilitation dietary counseling nutrition HSCT allogeneic hematopoietic stem cell transplantation hematopoietic stem cell transplantation

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Adult patients \>18 years will be eligible for inclusion if they are scheduled for a allo-HSCT with at least four weeks before their scheduled transplantation date.