Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
17 participants
OBSERVATIONAL
2025-08-30
2026-01-15
Brief Summary
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Before transplantation, it is important to assess patients' comorbidities, functional status, and physical fitness to evaluate their ability to tolerate treatment and risk of complications. Low exercise tolerance and impaired physical function are linked to poorer outcomes. Objective tests of physical function provide valuable information about health status. Pre-transplant muscle strength and cardiopulmonary fitness influence post-transplant recovery, so comprehensive assessments are necessary.
Physiotherapy and rehabilitation support patients by preparing them for treatment, maintaining health during therapy, improving physical function after treatment, and enhancing quality of life in palliative care. Exercise improves functional capacity, quality of life, and daily activities, but symptoms like fatigue, pain, breathlessness, and muscle weakness, as well as other barriers, may limit participation.
Physical fitness is the body's ability to perform daily activities efficiently. Reduced fitness leads to frailty and decreased function, which are associated with increased treatment toxicity and mortality. Although the importance of physical fitness before transplantation is recognized, data from objective measurements are limited. Common pre-transplant assessments include lung function tests, walking tests, handgrip strength, and mobility tests.
This study aims to compare the health-related physical fitness of individuals undergoing allogeneic hematopoietic stem cell transplantation with healthy controls.
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Detailed Description
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Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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Transplantation Group
Adult patients who underwent hematopoietic stem cell transplantation
Assessment Group
Allogeneic Stem Cell Transplant recipients will be evaluated with a supervisor physiotherapist for 2 days between the time they are admitted to the stem cell transplantation unit.
Control Group
Healthy adults
Control Group
Adult healthy group with similar sociodemographic characteristics to the evaluation group.
Interventions
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Assessment Group
Allogeneic Stem Cell Transplant recipients will be evaluated with a supervisor physiotherapist for 2 days between the time they are admitted to the stem cell transplantation unit.
Control Group
Adult healthy group with similar sociodemographic characteristics to the evaluation group.
Eligibility Criteria
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Inclusion Criteria
* Between 18 and 65 years of age
* Undergoing standard medical treatment including immunosuppressants, antibiotics, and other medications
* Clinically stable, able to walk, and cooperative
* No history of orthopedic, neurological, or cardiac disorders
Exclusion Criteria
* Orthopedic or neurological diseases that may affect the evaluation of physical fitness tests
* Presence of facial palsy
* Severe visual impairment or visual field defects
* Acute bleeding, hemoglobin level ≤ 8 g/dL, and platelet count ≤ 10,000/mm³
18 Years
65 Years
ALL
Yes
Sponsors
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Istinye University
OTHER
Responsible Party
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Kubra Koce
Asst. Prof.
Locations
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Istinye University
Istanbul, , Turkey (Türkiye)
Countries
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Other Identifiers
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24-03
Identifier Type: -
Identifier Source: org_study_id
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