Aquarius Pilot Study to Evaluate the New Axonics Trial System

NCT ID: NCT07335484

Last Updated: 2026-01-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-02-28

Study Completion Date

2026-12-31

Brief Summary

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Evaluation of the new Axonics External Trial System (ETS-02) in patients with overactive bladder (OAB) and/or fecal incontinence (FI).

Detailed Description

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The trial system is used to determine if patients are responsive to sacral neuromodulation (SNM) prior to receiving the Axonics implantable neurostimulator (INS) which is approved for the treatment of OAB and FI. This study is evaluating the feasibility and safety of the new Axonics External Trial System (ETS-02) in patients with overactive bladder (OAB) and/or fecal incontinence (FI).

Conditions

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Urinary Urge Incontinence (UUI) Urinary Frequency (UF) Fecal Incontinence (FI) Overactive Bladder (OAB)

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Patients diagnosed with OAB and/or FI who are candidates for Axonics SNM (PNE) procedure

External trial system used evaluated whether patients with OAB or FI will be responsive to sacral neuromodulation.

Group Type EXPERIMENTAL

Axonics External Trial System (ETS)

Intervention Type DEVICE

A temporary electrode wire is passed through the S3 foramen with or without fluoroscopic guidance. The wire is then connected to an external pulse generator (EPG) and is worn for a trial period ranging from 3-7 days.

Interventions

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Axonics External Trial System (ETS)

A temporary electrode wire is passed through the S3 foramen with or without fluoroscopic guidance. The wire is then connected to an external pulse generator (EPG) and is worn for a trial period ranging from 3-7 days.

Intervention Type DEVICE

Other Intervention Names

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Basic or Advanced Trial

Eligibility Criteria

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Inclusion Criteria

* 18 years or older
* Provides written informed consent prior to trial procedures
* Primary indication of OAB (UUI/UF) or chronic FI who are considered candidates for an Axonics PNE procedure as assessed by the physician per product IFU

Exclusion Criteria

* Any participant that the study Investigator deems to be a poor candidate for any reason, including, but not limited to, inability to complete a baseline bladder or bowel diary or to be compliant with study visits
* Planned changes to current regimen of medications during the trial period that could impact bladder or bowel function
* Current urinary tract mechanical obstruction (e.g., benign prostatic enlargement or urethral stricture)
* Current symptomatic urinary tract infection (UTI)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pacific Clinical Research Group

OTHER

Sponsor Role collaborator

Axonics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ailsa Wilson Edwards, MD

Role: PRINCIPAL_INVESTIGATOR

Calvary North Adelaide Hospital

Central Contacts

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Erum Shaikh

Role: CONTACT

949-396-6322

Gita Ghadimi, OD

Role: CONTACT

949-981-4366

Other Identifiers

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105-0179

Identifier Type: -

Identifier Source: org_study_id

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