Axonics SacRal NeuromodulaTIon System RegisTRY Study

NCT ID: NCT05064384

Last Updated: 2025-09-22

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

272 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-11-30

Study Completion Date

2024-03-31

Brief Summary

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To assess the post-market clinical outcomes with use of the Axonics Sacral Neuromodulation System(s).

Detailed Description

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The study will be a prospective, multi-center, single-arm, post-market registry study. Participant outcomes will be compared to their baseline, with participants serving as their own control.

The study is expected to complete enrollment in approximately 24 months and follow the patients per protocol for 1 year. The study was conducted at approximately 30 centers in the United States and Canada.

Conditions

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Urinary Retention Urinary Urge Incontinence Urgency-Frequency Fecal Incontinence

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Patients scheduled to be trialed with the Axonics External Trial System (ETS), or patients scheduled to receive an Axonics Implantable neurostimulator (INS) or Axonics FS implant
2. Willing and capable of providing informed consent
3. Capable of participating in all testing associated with this clinical investigation

Exclusion Criteria

For all indications:

1. Any significant medical condition that is likely to interfere with study procedures, device operation, or likely to confound evaluation of study endpoints
2. Any psychiatric or personality disorder at the discretion of the study physician
3. History of allergic response to titanium, zirconia, polyurethane, epoxy, or silicone
4. A female who is breastfeeding
5. A female with a positive urine pregnancy test

For OAB \& UR:
6. Current urinary tract mechanical obstruction (e.g. benign prostatic enlargement or urethral stricture)
7. Current symptomatic urinary tract infection (UTI)

For FI only:
8. Rectomucosal prolapse or congenital anorectal malformation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Axonics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Karen Noblett, MD

Role: STUDY_DIRECTOR

Axonics, Inc.

Locations

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Arkansas Urology Research Center

Little Rock, Arkansas, United States

Site Status

University of California, Irvine

Irvine, California, United States

Site Status

Stanford Medicine

Redwood City, California, United States

Site Status

Sansum Clinic Urology

Santa Barbara, California, United States

Site Status

Manatee Medical Research Institute

Bradenton, Florida, United States

Site Status

Urologic Solutions

Fort Myers, Florida, United States

Site Status

Florida Urology Partners

North Redington Beach, Florida, United States

Site Status

Pinellas Urology

St. Petersburg, Florida, United States

Site Status

Florida Urology Partners

Tampa, Florida, United States

Site Status

Northwestern

Chicago, Illinois, United States

Site Status

LSU Health

New Orleans, Louisiana, United States

Site Status

Ochsner Health

New Orleans, Louisiana, United States

Site Status

Chesapeake Urology

Hanover, Maryland, United States

Site Status

Comprehensive Urology

Royal Oak, Michigan, United States

Site Status

Adult Pediatric Urology & Urogynecology

Omaha, Nebraska, United States

Site Status

The Urology Center PC

Omaha, Nebraska, United States

Site Status

New Jersey Urology

Englewood, New Jersey, United States

Site Status

Stony Brook University

Stony Brook, New York, United States

Site Status

University of Cincinnati

Cincinnati, Ohio, United States

Site Status

Urologic Specialists Oklahoma

Tulsa, Oklahoma, United States

Site Status

Institute for Female Pelvic Medicine and Reconstructive Surgery

Allentown, Pennsylvania, United States

Site Status

Penn State University

Hershey, Pennsylvania, United States

Site Status

The Female Pelvic Health Center

Newtown, Pennsylvania, United States

Site Status

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status

Southern Urogynecology

West Columbia, South Carolina, United States

Site Status

Center for Pelvic Health

Franklin, Tennessee, United States

Site Status

University of Alberta

Edmonton, Alberta, Canada

Site Status

Countries

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United States Canada

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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105-0076

Identifier Type: -

Identifier Source: org_study_id

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