SAS 1: Develop Ocular Disease (OSD) Diagnostic, Algorithms, and Management Protocols for Cataract Surgery
NCT ID: NCT07323264
Last Updated: 2026-01-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
110 participants
OBSERVATIONAL
2025-06-27
2027-10-31
Brief Summary
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Industry: Recent advances in tear/cornea imaging and refractive cataract surgery such as multifocal intraocular lenses will be advantageous to patients only if tear film issues can be addressed.
Society: Cataract surgery is the most common ophthalmic surgery done in Singapore and worldwide. Improving vision by attending to tear film problems improves quality of life.
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Detailed Description
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Phase 1A: Longitudinal interventional parallel group study; small cohort to determine the impact of moderate dry eye for at-risk patient groups.
Phase 1B: Longitudinal interventional parallel group study; larger cohort of to compare outcomes based on different IOL types.
Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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Post LVC with Dry Eye undergoing cataract surgery
Post LVC with Dry Eye undergoing cataract surgery
No interventions assigned to this group
High corneal Astigmatism with Dry Eye undergoing cataract surgery
High corneal Astigmatism with Dry Eye undergoing cataract surgery
No interventions assigned to this group
Dry eye with no other risk factor undergoing cataract surgery
Dry eye with no other risk factor undergoing cataract surgery
No interventions assigned to this group
Patient undergoing Cataract Surgery implanted with EDoF/ EDoF Toric IOL With Dry Eye
Patient undergoing Cataract Surgery implanted with EDoF/ EDoF Toric IOL With Dry Eye
No interventions assigned to this group
Patient undergoing Cataract Surgery implanted with Multifocal/ MultifocalToric IOL With Dry Eye
Patient undergoing Cataract Surgery implanted with Multifocal/ MultifocalToric IOL With Dry Eye
No interventions assigned to this group
Patient undergoing Cataract Surgery implanted with Toric IOL With Dry Eye
Patient undergoing Cataract Surgery implanted with Toric IOL With Dry Eye
No interventions assigned to this group
Patient undergoing Cataract Surgery implanted with Monofocal IOL With Dry Eye
Patient undergoing Cataract Surgery implanted with Monofocal IOL With Dry Eye
No interventions assigned to this group
Patient undergoing Cataract Surgery implanted with EDoF/ EDoF Toric IOL Without Dry Eye
Patient undergoing Cataract Surgery implanted with EDoF/ EDoF Toric IOL Without Dry Eye
No interventions assigned to this group
Patient undergoing Cataract Surgery implanted with Multifocal/ MultifocalToric IOL Without Dry Eye
Patient undergoing Cataract Surgery implanted with Multifocal/ MultifocalToric IOL Without Dry Eye
No interventions assigned to this group
Patient undergoing Cataract Surgery implanted with Toric IOL Without Dry Eye
Patient undergoing Cataract Surgery implanted with Toric IOL Without Dry Eye
No interventions assigned to this group
Patient undergoing Cataract Surgery implanted with Monofocal IOL Without Dry Eye
Patient undergoing Cataract Surgery implanted with Monofocal IOL Without Dry Eye
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
2. Either use of diquasfosol, cyclosporine eyedrops or tacrolimus eyedrops for dry eye disease in the last 2 weeks (and previously started for more than 2 months), OR current and visible lower punctal plugs in at least one eye
1. DEQ5 \<=6.
2. Staining \< grade 1 in at least one corneal zone.
3. Not using diquasfosol, cyclosporine, tacrolimus in last 2 months.
4. No visible punctal plugs.
Exclusion Criteria
* Known diagnosis of active thyroid dysfunction, Sjogren disease and rheumatoid arthritis
* Intraocular surgery within the previous 6 months
* Laser-assisted in situ keratomileusis or pterygium surgery within the previous 3 months
* Central nervous system and hormonal drugs required within the last month and during the study
* Active ocular infection, inflamed chalazion, or presence of pterygium
* Glaucoma which requires topical anti-glaucoma medications
* Any need to wear contact lens during the study
* Having issues which make it difficult to follow up (eg., wheelchair, etc)
* Pregnant and breast-feeding woman
21 Years
99 Years
ALL
Yes
Sponsors
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Carl Zeiss Meditec AG
INDUSTRY
Louis Tong
OTHER_GOV
Responsible Party
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Louis Tong
Clinician-Scientist, Senior Consultant
Principal Investigators
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Louis Tong, PhD
Role: PRINCIPAL_INVESTIGATOR
Singapore Eye Research Institute
Locations
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Singapore Eye Research Institute
Singapore, , Singapore
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2025-0126
Identifier Type: REGISTRY
Identifier Source: secondary_id
2025-0126
Identifier Type: -
Identifier Source: org_study_id
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