Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis
NCT ID: NCT07316582
Last Updated: 2026-01-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
PHASE4
60 participants
INTERVENTIONAL
2025-11-01
2026-07-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Scaling and Root Planning only
Mechanical removal of supra- and subgingival plaque and calculus using ultrasonic and hand instruments.
No interventions assigned to this group
Injectable Platelet-Rich Fibrin (i-PRF)
local application of injectable platelet-rich fibrin (i-PRF) into periodontal pockets.
injectible platelet rich fibrin (i-PRF )
patients will be included in this group receiving (SRP) with local application of i-PRF
scaling and Root Planing plus Melatonin-Loaded Injectable Platelet-Rich Fibrin
patients will be included in this group receiving SRP with Melatonin loaded in (I-PRF) using insulin syringe for injection
Melatonin-Loaded Injectable Platelet-Rich Fibrin
patients will be included in this group receiving SRP with Melatonin loaded in (I-PRF) using insulin syringe for injection
Interventions
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Melatonin-Loaded Injectable Platelet-Rich Fibrin
patients will be included in this group receiving SRP with Melatonin loaded in (I-PRF) using insulin syringe for injection
injectible platelet rich fibrin (i-PRF )
patients will be included in this group receiving (SRP) with local application of i-PRF
Eligibility Criteria
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Inclusion Criteria
• Minimum of two non-adjacent periodontal pockets \<5 mm in different quadrants
• Systemically healthy individuals willing to participate and comply with follow-up visits
• Radiographic bone loss (ranged from is 10-20% mostly horizontal
Exclusion Criteria
• Use of antibiotics, anti-inflammatories, or antioxidant supplements in the past 3 months
• Smoking or tobacco use
• Pregnancy or lactation
• Allergy to melatonin or related compounds
\-
20 Years
60 Years
ALL
Yes
Sponsors
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Al-Azhar University
OTHER
Responsible Party
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Nora Abdelgawad Mohamed
Associate Professor of Oral Medicine, Periodontology and Diagnosis, Faculty of Dental Medicine for girls, Al -Azhar University, Cairo, Egypt
Locations
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Faculty of Dental Medicine for girls Al-Azhar University
New Cairo, , Egypt
Countries
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Other Identifiers
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P-ME-25-16
Identifier Type: -
Identifier Source: org_study_id
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