A Multicenter Retrospective Analysis of Postoperative Respiratory Complications in Children With Obstructive Sleepapnea

NCT ID: NCT07305168

Last Updated: 2025-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-05-02

Study Completion Date

2027-03-01

Brief Summary

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This retrospective observational study aims to evaluate postoperative respiratory complications (PORC) after (adeno)tonsillectomy in children with OSA.

In order to increase the number of patients available for analysis, we will merge data collected at UZA with data collected at the the Department of Sleep Laboratory and Sleep Surgery at the Heim Pal National Pediatric Institute, Hungary. These colleagues performed an identical prospective data collection.

Detailed Description

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This is a retrospective, multicenter cohort study using anonymized electronic health record data collected in a prospective study (PORC -EDGE 2364) performed at UZA and an identical prospective data collection performed by collegues at Department of Sleep Laboratory and Sleep surgery at Heim Pal National Pediatric Institute at Budapest.Data are collected from otherwise healthy children and children with varying comorbidities undergoing (adeno)-tonsillecty for Obstructive Sleepapnea (OSAS). Per-postoperative management was carried out according to a predefined treatment protocol.

As this study uses existing data, no informed consent was required. The aim of the current project is to answer the following questions.

* What is the prevalence of Postoperative Respiratory Complications (PORC) in children undergoing surgical treatment for OSA and is the prevalence different according to the underlying comorbid condition (i.e obesity, craniofacial malformation, syndromes Down syndrome, neurological conditions affecting upper airway muscle tone)?
* Which factors are associated with the occurrence of PORC (Polysomnogram (PSG) related factors such as obstructive Apnea-Hypopnea Index (oAHI), minimum oxygen saturation during PSG, and patient related factors such as age at time of surgery, presence of a comorbidity)?
* Is it possible to develop a management algorithm for postoperative management based upon the risk factors for PORC above.

Conditions

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Obstructive Sleep Apnea Postoperative Respiratory Complications Adenotonsillectomy Child Obesity Craniofacial Abnormalities Children With Down Syndrome Neurologic Disorder

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Children with Obstructive Sleepapnea (OSA)

Children with OSA after (adeno)tonsillectomy

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* scheduled for (adeno)tonsillectomy as treatment for OSAS

Exclusion Criteria

* other surgery than (adeno)tonsillectomy performed as treatment for OSAS
* Polysomnography not available within 1 year before surgery
Minimum Eligible Age

1 Year

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Antwerp

OTHER

Sponsor Role lead

Responsible Party

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Vera Saldien

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Vera Saldien, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Antwerp

Locations

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Antwerp University Hospital

Edegem, Antwerp, Belgium

Site Status RECRUITING

Heim Pal Children's Hospital

Budapest, , Hungary

Site Status COMPLETED

Countries

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Belgium Hungary

Central Contacts

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Vera Saldien, MD

Role: CONTACT

Phone: 38214788

Email: [email protected]

Joke De Wachter

Role: CONTACT

Phone: 38213042

Email: [email protected]

Facility Contacts

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Vera Saldien, MD, PhD

Role: primary

Joke De Wachter

Role: backup

Other Identifiers

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EDGE 004218

Identifier Type: -

Identifier Source: org_study_id