Defining Dosimetric Reference Levels in Computed Tomography Spectral Scanning
NCT ID: NCT07305103
Last Updated: 2025-12-26
Study Results
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Basic Information
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ACTIVE_NOT_RECRUITING
9600 participants
OBSERVATIONAL
2025-09-01
2026-06-30
Brief Summary
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The main objective of the study is to define dosimetric reference levels for the most commonly performed spectral computed tomography examinations in France.
Detailed Description
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However, unlike conventional CT scans, for which dosimetric reference levels (RLs) are defined for the most common examinations in France (RL decree dated 2019), there are currently no dosimetric reference levels for examinations performed using this technique. Yet the RL is an important and effective tool in optimizing patient exposure to ionizing radiation. In fact, a number of articles were published between 2012 and 2017, when the first dual-energy scanners arrived in clinics. However, the results presented in these studies are now far removed from recent practices, as they do not take into account the latest technological developments used in dual-energy scanners, which reduce X-ray doses.
The main objective of the study is to define dosimetric reference levels for the most frequently performed spectral computed tomography examinations in France:
1. Chest CT for pulmonary embolism
2. Chest CT for other indications
3. Coronary CT with contrast injection and retrospective gating
4. Coronary CT with contrast injection and prospective gating
5. Cranial CT with contrast injection
6. Supra-aortic trunk CT
7. Neck and ear,nose and throat sphere CT with contrast injection
8. Oncological abdomen-pelvis CT scan
9. Abdomen-pelvis CT scan to check for kidney stones
10. Abdomen-pelvis CT scan for non-oncological purposes and to check for kidney stones
11. Oncological chest-abdomen-pelvis CT scan
12. Non-oncological chest-abdomen-pelvis CT scan
13. Oncological chest-abdomen CT scan
14. Non-oncological chest-abdomen CT scan
15. Lower limb angiography
16. Cervical spine CT scan
17. Thoracic spine CT scan
18. Lumbar spine CT scan
19. Pelvis CT scan,
20. Extremities CT scan
The secondary objectives of the study are to evaluate, for each examination performed:
1. the impact of the spectral acquisition/detection technique on the dose delivered to patients.
2. the impact of patients' BMI on the dose delivered to patients.
3. the impact of reconstruction algorithms on the dose delivered to patients.
Conditions
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Keywords
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Patients undergoing a maximum number of 18 spectral CT scans among the examinations mentioned below
Patients undergoing a maximum number of 18 spectral CT scans among the examinations mentioned below:
1. Chest CT for pulmonary embolism
2. Chest CT for other indications
3. Coronary CT with contrast injection and retrospective gating
4. Coronary CT with contrast injection and prospective gating
5. Cranial CT with contrast injection
6. Supra-aortic trunk CT
7. Neck and ear,nose and throat sphere CT with contrast injection
8. Oncological abdomen-pelvis CT scan
9. Abdomen-pelvis CT scan to check for kidney stones
10. Abdomen-pelvis CT scan for non-oncological purposes and to check for kidney stones
11. Oncological chest-abdomen-pelvis CT scan
12. Non-oncological chest-abdomen-pelvis CT scan
13. Oncological chest-abdomen CT scan
14. Non-oncological chest-abdomen CT scan
15. Lower limb angiography
16. Cervical spine CT scan
17. Thoracic spine CT scan
18. Lumbar spine CT scan
19. Pelvis CT scan,
20. Extremities CT scan
Spectral ComputedTomography
Commonly performed spectral computed tomography examinations in France
Interventions
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Spectral ComputedTomography
Commonly performed spectral computed tomography examinations in France
Eligibility Criteria
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Inclusion Criteria
* Body Mass Index (BMI) between 18 and 35 kg/m²
* Patients who underwent a spectral CT scan between January 1, 2023, and August 31, 2024, as part of their treatment.
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Institut Paoli Calmettes, Marseille
UNKNOWN
Hôpital Necker-Enfants Malades
OTHER
Lille University Hospital
UNKNOWN
CHU Hôpital Lariboisière APHP
UNKNOWN
Centre Hospitalier Universitaire de Saint Etienne
OTHER
Saint-Louis Hospital, Paris, France
OTHER
Bichat Hospital, Paris, France
UNKNOWN
Hôpital Louis Mourier, 92700 Colombes
UNKNOWN
Centre Hospitalier de Valenciennes
NETWORK
Hopital Louis Pradel
OTHER
Centre Léon Bérard, Lyon
UNKNOWN
University Hospital, Bordeaux
OTHER
Centre Hospitalier Lyon Sud
OTHER
Institut Curie
OTHER
Amiens University Hospital
OTHER
Poitiers University Hospital
OTHER
Henri Mondor Hospital, Créteil
UNKNOWN
Saint Antoine University Hospital
OTHER
Nord Ardennes Intercommunal Hospital
UNKNOWN
Centre Antoine Lacassagne, Nice
UNKNOWN
Hôpital Edouard Herriot (GH Centre), Lyon
UNKNOWN
Centre Hospitalier Universitaire de Nīmes
OTHER
Responsible Party
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Principal Investigators
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Joël GREFFIER
Role: STUDY_CHAIR
Nîmes University Hospital
Locations
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Nîmes University Hospital
Nîmes, Gard, France
Countries
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References
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Si-Mohamed SA, Boccalini S, Villien M, Yagil Y, Erhard K, Boussel L, Douek PC. First Experience With a Whole-Body Spectral Photon-Counting CT Clinical Prototype. Invest Radiol. 2023 Jul 1;58(7):459-471. doi: 10.1097/RLI.0000000000000965. Epub 2023 Feb 22.
Wortman JR, Shyu JY, Dileo J, Uyeda JW, Sodickson AD. Dual-energy CT for routine imaging of the abdomen and pelvis: radiation dose and image quality. Emerg Radiol. 2020 Feb;27(1):45-50. doi: 10.1007/s10140-019-01733-9. Epub 2019 Nov 1.
Henzler T, Fink C, Schoenberg SO, Schoepf UJ. Dual-energy CT: radiation dose aspects. AJR Am J Roentgenol. 2012 Nov;199(5 Suppl):S16-25. doi: 10.2214/AJR.12.9210.
Ghasemi Shayan R, Oladghaffari M, Sajjadian F, Fazel Ghaziyani M. Image Quality and Dose Comparison of Single-Energy CT (SECT) and Dual-Energy CT (DECT). Radiol Res Pract. 2020 Apr 20;2020:1403957. doi: 10.1155/2020/1403957. eCollection 2020.
Greffier J, Villani N, Defez D, Dabli D, Si-Mohamed S. Spectral CT imaging: Technical principles of dual-energy CT and multi-energy photon-counting CT. Diagn Interv Imaging. 2023 Apr;104(4):167-177. doi: 10.1016/j.diii.2022.11.003. Epub 2022 Nov 19.
Dabli D, Frandon J, Belaouni A, Akessoul P, Addala T, Berny L, Beregi JP, Greffier J. Optimization of image quality and accuracy of low iodine concentration quantification as function of dose level and reconstruction algorithm for abdominal imaging using dual-source CT: A phantom study. Diagn Interv Imaging. 2022 Jan;103(1):31-40. doi: 10.1016/j.diii.2021.08.004. Epub 2021 Oct 6.
Noda Y, Kawai N, Kawamura T, Kobori A, Miyase R, Iwashima K, Kaga T, Miyoshi T, Hyodo F, Kato H, Matsuo M. Radiation and iodine dose reduced thoraco-abdomino-pelvic dual-energy CT at 40 keV reconstructed with deep learning image reconstruction. Br J Radiol. 2022 Jun 1;95(1134):20211163. doi: 10.1259/bjr.20211163. Epub 2022 Mar 4.
Etard C, Bigand E, Salvat C, Vidal V, Beregi JP, Hornbeck A, Greffier J. Patient dose in interventional radiology: a multicentre study of the most frequent procedures in France. Eur Radiol. 2017 Oct;27(10):4281-4290. doi: 10.1007/s00330-017-4780-5. Epub 2017 Mar 13.
Greffier J, Ferretti G, Rousseau J, Andreani O, Alonso E, Rauch A, Gillet R, Le Roy J, Cabrol-Faivre L, Douane F, David A, Henry S, Jacques T, Stefanovic X, Decoux E, Lafay F, Pilleul F, Couzon F, Boutet C, Woerly B, Baur P, Sans N, Faruch M, Moussier-Lherm A, Tselikas L, Jacquier A, Bigand E, Pessis E, Teriitehau C, Magnier F, Cassagnes L, Haberlay M, Boutteau D, De Kerviler E, Majorel-Gouthain C, Defez D, Vuillod A, Rouviere O, Hennequin L, Fohlen A, Alwan R, Malakhia A, Aubry S, Dohan A, Eresue-Bony M, Gautier R, Dal R, Dabli D, Hebert T, Kovacs R, Hadid-Beurrier L, Bousson V, Potel M, Barbotteau Y, Michel C, Habib-Geryes B, Andre M, Arnaud T, Bestion N, Ernst O, Monfraix S, Brillet PY, Guiu B, Boussel L, Demonchy M, Beregi JP, Frandon J. National dose reference levels in computed tomography-guided interventional procedures-a proposal. Eur Radiol. 2020 Oct;30(10):5690-5701. doi: 10.1007/s00330-020-06903-9. Epub 2020 May 2.
Other Identifiers
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NIMAO/2024-1/DD-01
Identifier Type: -
Identifier Source: org_study_id