Autonomic Dysfunction in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis : A Comparative Study
NCT ID: NCT07273292
Last Updated: 2025-12-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
100 participants
OBSERVATIONAL
2026-01-20
2028-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Interventions
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Bedside cardiovascular reflex tests
These tests evaluate both parasympathetic and sympathetic components of cardiovascular regulation.
Eligibility Criteria
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Inclusion Criteria
* Confirmed diagnosis of NMOSD according to the 2015 International Consensus Criteria.
* Confirmed diagnosis of RRMS according to the 2024 McDonald diagnostic criteria.
Exclusion Criteria
* Medications known to interfere with autonomic testing.
* Cognitive impairment precluding questionnaire completion.
18 Years
ALL
No
Sponsors
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Mohamed Moshref abd alsattar
OTHER
Responsible Party
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Mohamed Moshref abd alsattar
Resident doctor at neurology and psychiatry department
Central Contacts
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References
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Pigg S, Cautley D, Francisco PW. Impacts of weatherization on indoor air quality: A field study of 514 homes. Indoor Air. 2018 Mar;28(2):307-317. doi: 10.1111/ina.12438. Epub 2017 Nov 27.
Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983 Nov;33(11):1444-52. doi: 10.1212/wnl.33.11.1444.
Sletten DM, Suarez GA, Low PA, Mandrekar J, Singer W. COMPASS 31: a refined and abbreviated Composite Autonomic Symptom Score. Mayo Clin Proc. 2012 Dec;87(12):1196-201. doi: 10.1016/j.mayocp.2012.10.013.
Cohen JA. 2024 revision of the McDonald diagnostic criteria for MS: Substantial and substantive changes. Mult Scler. 2025 Oct;31(11):1269-1275. doi: 10.1177/13524585251351860. Epub 2025 Jul 13. No abstract available.
Pentland B, Ewing DJ. Cardiovascular reflexes in multiple sclerosis. Eur Neurol. 1987;26(1):46-50. doi: 10.1159/000116311.
HAMILTON JE, HALL WM, HARBRECHT PJ. Carcinoma of the tongue: its behavior and management. Surgery. 1960 Aug;48:385-90. No abstract available.
BLEWETT J. Manifestations of yaws in Great Britain. Br J Radiol. 1959 Mar;32(375):198-201. doi: 10.1259/0007-1285-32-375-198. No abstract available.
Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG; International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology. 2015 Jul 14;85(2):177-89. doi: 10.1212/WNL.0000000000001729. Epub 2015 Jun 19.
Frileck S. The work. Plast Reconstr Surg. 2003 Aug;112(2):681-3. doi: 10.1097/01.PRS.0000070942.73903.FD. No abstract available.
Crnosija L, Krbot Skoric M, Andabaka M, Junakovic A, Martinovic V, Ivanovic J, Mesaros S, Pekmezovic T, Drulovic J, Habek M. Autonomic dysfunction in people with neuromyelitis optica spectrum disorders. Mult Scler. 2020 May;26(6):688-695. doi: 10.1177/1352458519837703. Epub 2019 Mar 19.
Racosta JM, Kimpinski K. Autonomic dysfunction, immune regulation, and multiple sclerosis. Clin Auton Res. 2016 Feb;26(1):23-31. doi: 10.1007/s10286-015-0325-7. Epub 2015 Dec 21.
Cortez MM, Nagi Reddy SK, Goodman B, Carter JL, Wingerchuk DM. Autonomic symptom burden is associated with MS-related fatigue and quality of life. Mult Scler Relat Disord. 2015 May;4(3):258-63. doi: 10.1016/j.msard.2015.03.007. Epub 2015 Apr 8.
Habek M, Crnosija L, Lovric M, Junakovic A, Krbot Skoric M, Adamec I. Sympathetic cardiovascular and sudomotor functions are frequently affected in early multiple sclerosis. Clin Auton Res. 2016 Dec;26(6):385-393. doi: 10.1007/s10286-016-0370-x. Epub 2016 Jul 22.
Jarius S, Wildemann B. The history of neuromyelitis optica. J Neuroinflammation. 2013 Jan 15;10:8. doi: 10.1186/1742-2094-10-8.
Noyes K, Weinstock-Guttman B. Impact of diagnosis and early treatment on the course of multiple sclerosis. Am J Manag Care. 2013 Nov;19(17 Suppl):s321-31.
Other Identifiers
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Autonomics in NMO and MS
Identifier Type: -
Identifier Source: org_study_id
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