Efficacy/ Safety of Product DNN.65.21.005 in Patients With Benign Prostatic Hyperplasia

NCT ID: NCT07270432

Last Updated: 2025-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

218 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-31

Study Completion Date

2027-04-30

Brief Summary

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To evaluate the safety and efficacy of DNN.65.21.005 versus Combodart® in the treatment of benign prostatic hyperplasia

Detailed Description

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Conditions

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Prostatic Hyperplasia, Benign

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Product DNN.65.21.005

Group Type EXPERIMENTAL

Product DNN.65.21.005

Intervention Type DRUG

One capsule every 24 hours

Combodart®

Group Type ACTIVE_COMPARATOR

Combodart®

Intervention Type DRUG

One capsule every 24 hours

Interventions

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Product DNN.65.21.005

One capsule every 24 hours

Intervention Type DRUG

Combodart®

One capsule every 24 hours

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male participants aged 50 years and older.
* Ability to understand the study and provide informed consent, documented by signing the Informed Consent Form (ICF).
* Participants presenting lower urinary tract symptoms (LUTS) associated with prostate enlargement, without neurological or infectious causes.

Exclusion Criteria

* History or evidence of prostate cancer.
* Urinary retention ≥100 mL, as assessed by abdominal prostate ultrasound.
* Previous diagnosis of Parkinson's disease or other neurological disorders that may lead to neurogenic bladder.
* Use of herbal treatments for prostate enlargement within 14 days prior to the screening visit.
* Current use or use of alpha-blocker medications within 7 days prior to the start of study treatment.
* Current use or use of 5-alpha reductase inhibitors (5ARIs) within 180 days prior to the start of study treatment.
* Use of any prohibited medications within the timeframe specified in the study protocol.
* Any clinical findings or observations (clinical or physical evaluation) that, in the investigator's judgment, pose a risk to participation in the study.
Minimum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Ache Laboratorios Farmaceuticos S.A.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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ACH-DTS-03(03/22)

Identifier Type: -

Identifier Source: org_study_id

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