A Family-centred Approach Enhancing Cardiovascular Health in Ugandan Adolescents and Their Families

NCT ID: NCT07265453

Last Updated: 2025-12-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

1280 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-05

Study Completion Date

2028-01-31

Brief Summary

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The FaCe-D Study, with funding from the Canadian Institute for Health Research (CIHR) through Global Alliance for Chronic Diseases (GACD) aims to adapt and implement an evidence-based family centred approach (FCA) to prevent cardiovascular diseases (CVD) among adolescents and their families. This 5-year implementation science study will be conducted in 16 villages in Jinja district and another 16 in Kampala beginning April 2024 to evaluate the effectiveness of FCA in reducing the risk of CVD in Uganda and to assess feasibility, adoption, while measuring the costs of implementation. The study will be implemented by a group of researchers from MRC/UVRI \& LSHTM, University of British Columbia (Canada), TASO (Uganda) and University of California San Francisco (UCSF) - USA with guidance from the Ministry of Health - Uganda.

Detailed Description

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Uganda faces a growing challenge of non-communicable diseases (NCDs) alongside the existing burden due to HIV/AIDS. By NCDs, the investigators refer to common conditions such as diabetes, cancers, and cardiovascular diseases (including hypertension, stroke, and heart attack). About 38.8% of the population in Uganda has raised blood pressure (pre-hypertension), 34% in urban and 22% in rural areas have hypertension. The risk factors, such as unhealthy diet and physical inactivity, responsible for the development of these NCDs are modifiable and related to behaviour. The investigators propose to adapt, implement and evaluate a family-centred approach to enhance behaviour change among adolescents and their families.

Why focus on Adolescents? The investigators recognize that adolescence is a critical stage marked by significant physical, cognitive, and social changes and time to adopt behaviour that extends into adulthood. Previous studies have shown that even if the signs and symptoms of cardiovascular disease appear in adulthood, the process starts earlier during adolescence. The investigators aim to intervene by working with adolescents and families to change their behaviors and adopt a healthier diet and engage in recommended level of physical.

The iHealth T2D study that was conducted in parts of Asia and the United Kingdom showed that using the family centered approach and working closely with community health care workers led to reduction in body weight, blood pressure and thus reducing the risk of NCDs among the Asian population. The investigators will adapt the iHealth T2D study intervention to the Ugandan context, considering the specific features of the setting, village health team responsibilities and content of the education material. The intervention will promote physical activity and healthy eating habits among families.

The study comprises three phases; a) formative phase which is focusing on adapting the intervention, b) Implementation phase, to implement the adapted intervention and c) evaluation phase, assessing effectiveness and the overall process of the adapted intervention.

Conditions

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Adolescent Behavior Lifestyle Modification Cardiovascular Disease Other

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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FaCe-D Control arm

Group Type ACTIVE_COMPARATOR

Control Arm - standard of care

Intervention Type OTHER

Arm Description: They will continue to receive standard care with VHts performing their usual roles of health promotion for both communicable and non-communicable diseases as outlined by the Ministry of Health guidelines. This standard care involves visits by the VHT at least once a quarter to check hygiene and environment, children's immunisation status and other health promotion activities. The VHT may or may not involve the entire family/household.

FaCe-D Intervention

Family-centred approach for lifestyle changes and behavioural modification

Group Type EXPERIMENTAL

The immediate (treatment) arm, will receive the FaCe-D intervention comprising of 'HOME VISITS, DIET, PHYSICAL ACTIVITY AND HEALTH MESSAGING

Intervention Type BEHAVIORAL

The participants will receive the FaCe-D intervention comprising of dietary and exercise interventions delivered by Village Health Teams (VHTs)

Interventions

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The immediate (treatment) arm, will receive the FaCe-D intervention comprising of 'HOME VISITS, DIET, PHYSICAL ACTIVITY AND HEALTH MESSAGING

The participants will receive the FaCe-D intervention comprising of dietary and exercise interventions delivered by Village Health Teams (VHTs)

Intervention Type BEHAVIORAL

Control Arm - standard of care

Arm Description: They will continue to receive standard care with VHts performing their usual roles of health promotion for both communicable and non-communicable diseases as outlined by the Ministry of Health guidelines. This standard care involves visits by the VHT at least once a quarter to check hygiene and environment, children's immunisation status and other health promotion activities. The VHT may or may not involve the entire family/household.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged 10 -19 years
* Household head/parent has provided consent/permission
* Planning to continue staying in the study village for the next 12 months

Exclusion Criteria

* In a boarding school or planning to join a boarding school
* Pregnant or lactating
* Known to have a chronic condition such as mental illness
* The adolescent does not assent or consent
Minimum Eligible Age

10 Years

Maximum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of California

OTHER

Sponsor Role collaborator

The AIDS Support Organization

OTHER

Sponsor Role collaborator

University of British Columbia

OTHER

Sponsor Role collaborator

MRC/UVRI and LSHTM Uganda Research Unit

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dr Josephine Birungi

Role: PRINCIPAL_INVESTIGATOR

MRC/UVRI and LSHTM Uganda Research Unit

Prof Rachel King, PhD

Role: PRINCIPAL_INVESTIGATOR

University of California, San Francisco

Prof David Moore, PhD

Role: PRINCIPAL_INVESTIGATOR

University of British Columbia

Locations

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TASO Jinja

Jinja, , Uganda

Site Status RECRUITING

Kiswa Health center III

Kampala, , Uganda

Site Status RECRUITING

Countries

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Uganda

Central Contacts

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Arthur Namara, MSc

Role: CONTACT

+256782199612

Chairperson, UVRI REC, PhD

Role: CONTACT

+256414321962 ext. +256716321962

Facility Contacts

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Sanula Nanozi, BSc Nursing

Role: primary

256788343149

Dr Simple Ouma, PhD Candidate

Role: backup

+256707708818

Isaac Kintu, MSc

Role: primary

+256750814989

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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RGJB230801

Identifier Type: -

Identifier Source: org_study_id

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