Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America
NCT ID: NCT07262320
Last Updated: 2026-01-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
1000 participants
OBSERVATIONAL
2026-03-01
2027-06-30
Brief Summary
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* What is the epidemiology, outcomes, and processes of care for patients with AKI-RRT in Latin America?
* How do outcomes differ across different countries in Latin America?
* What factors (demographics, clinical, socioeconomic) influence outcomes in patients with AKI-RRT in Latin America?
The main aims of this study are to:
* Establish a comprehensive database containing clinical, laboratory, treatment, process, and outcome data of patients with AKI-RRT in Latin America
* Describe current epidemiology of AKI-RRT in Latin America
* Compare processes of care and outcomes across different countries in Latin America
* Provide data resources to facilitate and promote clinical research in AKI-RRT
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Acute kidney injury patients requiring renal replacement therapy
Critically ill adult patients with acute kidney injury undergoing any form of renal replacement therapy in Latin American hospitals
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* First ICU admission during current hospitalization
* Diagnosis of acute kidney injury stage 3 according to KDIGO guidelines
* RRT initiated no earlier than 3 days before or no later than 7 days after ICU admission
Exclusion Criteria
* RRT exposure of less than 2 days (if CRRT or PD was provided) or less than 2 HD/SLED sessions
* Kidney failure (ESRD) patients on maintenance dialysis
* Kidney transplant recipients
* Previous or new diagnosis of glomerulonephritis
18 Years
ALL
No
Sponsors
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Vantive Health LLC
INDUSTRY
University of Alabama at Birmingham
OTHER
Responsible Party
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Javier A. Neyra
Professor of Medicine
Principal Investigators
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Javier A Neyra, MD, MSCS
Role: PRINCIPAL_INVESTIGATOR
University of Alabama at Birmingham
Locations
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Hospital Obrero No 2
Cochabamba, , Bolivia
Ana Nery Hospital
Bahia, , Brazil
Hospital Sao Lucas da PUCRS
Porto Alegre, , Brazil
Hospital das Clínicas da Universidade de São Paulo
São Paulo, , Brazil
Hospital Las Higueras
Talcahuano, , Chile
Fundación Cardioinfantil
Bogotá, , Colombia
Hospital San Jose de Popayan
Popayán, , Colombia
DIALNEF
Quito, , Ecuador
Instituto Guatemalteco de Seguridad Social
Guatemala City, , Guatemala
Hospital Civil de Guadalajara
Guadalajara, , Mexico
Hospital General de México Dr Eduardo Liceaga
Mexico City, , Mexico
Hospital Universitario "José Eleuterio González"
Monterrey, , Mexico
Hospital Nacional Arzobispo Loayza
Lima, , Peru
Countries
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Central Contacts
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Facility Contacts
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References
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Bello AK, McIsaac M, Okpechi IG, Johnson DW, Jha V, Harris DCH, Saad S, Zaidi D, Osman MA, Ye F, Lunney M, Jindal K, Klarenbach S, Kalantar-Zadeh K, Kovesdy CP, Parekh RS, Prasad B, Khan M, Riaz P, Tonelli M, Wolf M, Levin A; ISN North America and the Caribbean Regional Board. International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in North America and the Caribbean. Kidney Int Suppl (2011). 2021 May;11(2):e66-e76. doi: 10.1016/j.kisu.2021.01.001. Epub 2021 Apr 12.
Wainstein M, Nlandu Y, Viecelli A, Neyra JA, Arruebo S, Caskey FJ, Damster S, Donner JA, Jha V, Levin A, Nangaku M, Saad S, Tonelli M, Ye F, Okpechi IG, Bello AK, Johnson DW, Cerda J. A global snapshot on health systems capacity for detection, monitoring, and management of acute kidney injury: A multinational study from the ISN-GKHA. PLOS Glob Public Health. 2024 Oct 15;4(10):e0003823. doi: 10.1371/journal.pgph.0003823. eCollection 2024.
Mehta RL, Burdmann EA, Cerda J, Feehally J, Finkelstein F, Garcia-Garcia G, Godin M, Jha V, Lameire NH, Levin NW, Lewington A, Lombardi R, Macedo E, Rocco M, Aronoff-Spencer E, Tonelli M, Zhang J, Remuzzi G. Recognition and management of acute kidney injury in the International Society of Nephrology 0by25 Global Snapshot: a multinational cross-sectional study. Lancet. 2016 May 14;387(10032):2017-25. doi: 10.1016/S0140-6736(16)30240-9. Epub 2016 Apr 13.
Rehman AU, Renzi S, Castro DAB, Cervantes L, Clavero R, Davidson B, Farias MR, Girard VC, Claure-Del Granado R, Ramirez-Guerrero G, Jimenez D, Leon Rabanal CP, Molano Trivino A, Reis T, Rizo-Topete L, Vega-Vega O, Viecelli AK, Kamile Singer Wallbach-Massai K, Wainstein M, Karam S, Neyra JA. Barriers and Facilitators to Renal Replacement Therapy for Acute Kidney Injury in Latin America: Insights From an Expert Roundtable. Kidney Int Rep. 2025 Jun 19;10(8):2515-2519. doi: 10.1016/j.ekir.2025.06.030. eCollection 2025 Aug. No abstract available.
Ponce D, Balbi A. Acute kidney injury: risk factors and management challenges in developing countries. Int J Nephrol Renovasc Dis. 2016 Aug 22;9:193-200. doi: 10.2147/IJNRD.S104209. eCollection 2016.
Susantitaphong P, Cruz DN, Cerda J, Abulfaraj M, Alqahtani F, Koulouridis I, Jaber BL; Acute Kidney Injury Advisory Group of the American Society of Nephrology. World incidence of AKI: a meta-analysis. Clin J Am Soc Nephrol. 2013 Sep;8(9):1482-93. doi: 10.2215/CJN.00710113. Epub 2013 Jun 6.
Lombardi R, Rosa-Diez G, Ferreiro A, Greloni G, Yu L, Younes-Ibrahim M, Burdmann EA; Acute Kidney Injury Committee of the Latin American Society of Nephrology and Hypertension Working Group. Acute kidney injury in Latin America: a view on renal replacement therapy resources. Nephrol Dial Transplant. 2014 Jul;29(7):1369-76. doi: 10.1093/ndt/gfu078. Epub 2014 Apr 16.
Other Identifiers
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IIR from Vantive
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
IRB-300013633
Identifier Type: -
Identifier Source: org_study_id
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