Composite Ratios Boost CRP's Power in Monitoring Ulcerative Colitis.

NCT ID: NCT07261579

Last Updated: 2026-01-21

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-09-15
• Study Completion Date: 2025-12-01

Brief Summary

Inflammatory Bowel Disease (IBD) is a chronic, recurrent condition marked by disturbed levels of various hematological inflammatory cells and a deregulated immune environment. While C-reactive protein (CRP) is a key acute-phase reactant, its high levels can persist even after inflammation subsides. Other simple, cost-effective ratios, such as the Neutrophil-to-Lymphocyte Ratio (NLR), the Platelet-to-Lymphocyte Ratio (PLR), and Albumin-related ratios, also serve as promising, reproducible markers of systemic inflammation reflecting both immune status and nutrition. This study's objective is to evaluate the diagnostic performance of these various hematological inflammatory cellular components and CRP-related ratios (like the CAR) as predictors for Ulcerative Colitis (UC) disease severity, using colonoscopic and microscopic findings as the gold standard for comparison.

Conditions

Ulcerative Colitis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Ulcerative Colitis Patients

Patients exhibiting clinical signs suggestive of IBD were assessed for UC diagnostic criteria, and the study inclusion and exclusion standards.

C-Reactive Protein measuring CRP

Intervention Type: DIAGNOSTIC_TEST

5-ml peripheral blood samples were aseptically obtained for a complete blood count, and ELISA estimation of serum CRP

CRP to Albumin Ratio

Intervention Type: DIAGNOSTIC_TEST

Serum CRP to albumin ratio (CAR) is a combination of markers for systemic inflammation and nutritional status

Interventions

C-Reactive Protein measuring CRP

5-ml peripheral blood samples were aseptically obtained for a complete blood count, and ELISA estimation of serum CRP

Intervention Type: DIAGNOSTIC_TEST

CRP to Albumin Ratio

Serum CRP to albumin ratio (CAR) is a combination of markers for systemic inflammation and nutritional status

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Patients who fulfilled the diagnostic criteria for UC;

Exclusion Criteria

• Patients who signed the written consent were enrolled in the study

• Patients who was Previously diagnosed with IBD or IBS;
• Patients with recurrence of manifestations after surgical resection;
• Patients who refused to sign the participation consent.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Benha University

OTHER

Sponsor Role: lead

Responsible Party

Raafat R. Mohammed

Assistant consultant of Clinical Pathology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Alexandria Faculty of medicine

Alexandria, El Alexandria, Egypt

Countries

Egypt

Other Identifiers

E/C. S/N. R14/2025

Identifier Type: -

Identifier Source: org_study_id