Association Between Vitamin D Deficiency and Inflammatory Bowel Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2026-01-31

Study Completion Date

2027-06-30

Brief Summary

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Crohn's disease (CD) and ulcerative colitis (UC) are two major types of inflammatory bowel disease (IBD) that are identified by different clinical, endoscopic, pathological, and radiologic diagnostic methods.

In the past few years, the incidence of inflammatory bowel disease has been increasing worldwide, with the incidence of UC being higher than that of CD.

Vitamin D is a fat-soluble vitamin that is produced in the skin by a UV-dependent reactionand then hydroxylated by the kidneys and liver, and is converted to its active form, 1,25-dihydroxyvitamin D.

Vitamin D deficiency is common throughout the world and its deficiency rates ranging from 30 to 50% have been reported.

Several studies have shown the role of vitamin D as a regulator of the immune system and its inhibitory function incellular immunity and production of pro-inflammatory cytokines that play a major role in autoimmune diseases.

In some human studies, the link between vitamin D levels and the disease severity of IBD has been shown, but it is not clear whether lack of vitamin D is the cause or consequence.

In this study, we aimed to investigate the relationship between inflammatory bowel disease and itsflare-up with serum levels of vitamin D

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Detailed Description

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Conditions

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Inflammatory Bowel Diseases

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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patients diagnosed with Crohn's disease (CD) and ulcerative colitis (UC)

Adults aged ≥18 years, diagnosed with Crohn's disease (CD) and ulcerative colitis (UC), and on regular follow-up in the IBD clinic, are followed up for recent vitamin D and disease activity assessment (within 1 month)

Serum 25(OH)D (Vitamin D3), C- reactive protein, Erthrocyte sedimentation rate

Intervention Type DIAGNOSTIC_TEST

Serum 25(OH)D (Vitamin D3), C- reactive protein, Erthrocyte sedimentation rate are evaluated to assess vitamin D deficiency and IBD activity

Interventions

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Serum 25(OH)D (Vitamin D3), C- reactive protein, Erthrocyte sedimentation rate

Serum 25(OH)D (Vitamin D3), C- reactive protein, Erthrocyte sedimentation rate are evaluated to assess vitamin D deficiency and IBD activity

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Adults aged ≥18 years
* Diagnosed with crohn's and ulcerative colitis
* Regular follow-up in IBD clinic
* Recent vitamin D and disease activity assessment (within 1 month)

Exclusion Criteria

* Current vitamin D supplementation(\>1000IU/day)

* History of malabsorption syndromes (e.g.,celiac disease)
* Chronic kidney or liver disease
* Pregnancy

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No