RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis

NCT ID: NCT07258784

Last Updated: 2025-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-09-11

Study Completion Date

2026-12-31

Brief Summary

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Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring. It can be secondary to iatrogenic etiologies such as intubation or tracheostomy , as well as autoimmune diseases and being idiopathic. Patients typically undergoes endoscopic or surgical interventions to open up the airways. This project will analyze resected or biopsied tissue from patients with benign tracheal stenosis to define disease-specific RNA expression profiles.

Detailed Description

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Conditions

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Tracheal Stenosis Subglottic Stenosis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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patients with benign tracheal stenosis undergoing either endoscopic or surgical treatment

Biopsy or surgery

Intervention Type PROCEDURE

The tissue will be obtained from biopsy or surgical resection. All the "intervention" will be performed for clinical needs. The tissue used in the study will be considered as discarded tissue

Interventions

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Biopsy or surgery

The tissue will be obtained from biopsy or surgical resection. All the "intervention" will be performed for clinical needs. The tissue used in the study will be considered as discarded tissue

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with benign tracheal stenosis

Exclusion Criteria

* Malignancy. active infection
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Maryland, Baltimore

OTHER

Sponsor Role lead

Responsible Party

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Chenchen Zhang

Assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Maryland

Baltimore, Maryland, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Chenchen Zhang, MD

Role: CONTACT

14103288141

Facility Contacts

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Chenchen Zhang

Role: primary

4103288141

Other Identifiers

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HP-00114191

Identifier Type: -

Identifier Source: org_study_id

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