Study of Interventional Pulmonologic Treatment of Benign Central Airway Fibrotic Stricture

NCT ID: NCT02287389

Last Updated: 2014-11-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

160 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-12-31

Study Completion Date

2017-12-31

Brief Summary

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The purpose of this study is to evaluate the efficacy and safety of four interventional pulmonology techniques for the treatment of fibrotic central airway stricture.

The four techniques are:

* balloon dilation
* balloon dilation plus cryotherapy
* balloon dilation plus spiculiform electrosurgery
* balloon dilation plus mitomycin C injection

Detailed Description

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Conditions

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Obstructive Airway Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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balloon dilation

give the cases balloon dilation as the intervention

Group Type EXPERIMENTAL

balloon dilation

Intervention Type DEVICE

balloon dilation plus cryotherapy

give the cases balloon dilation plus cryotherapy as the intervention

Group Type EXPERIMENTAL

balloon dilation

Intervention Type DEVICE

cryotherapy

Intervention Type PROCEDURE

BD plus spiculiform electrosurgery

give the cases balloon dilation plus spiculiform electrosurgery as the intervention

Group Type EXPERIMENTAL

balloon dilation

Intervention Type DEVICE

spiculiform electrosurgery

Intervention Type PROCEDURE

BD plus mitomycin C

give the cases Balloon dilation plus mitomycin C as the intervention

Group Type EXPERIMENTAL

balloon dilation

Intervention Type DEVICE

mitomycin C

Intervention Type DRUG

Interventions

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balloon dilation

Intervention Type DEVICE

cryotherapy

Intervention Type PROCEDURE

spiculiform electrosurgery

Intervention Type PROCEDURE

mitomycin C

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* tracheal incision,intubation or bronchial tuberculosis caused central airway fibrotic stenosis
* the degree of stenosis is above 50%
* estimated survival duration is longer than 3 months
* recieved no treatment one month before
* can understand the statement informed consent
* agree to enroll in the study

Exclusion Criteria

* older than 70 years or younger than 18 years
* not fibrotic stenosis
* not central airway stenosis
* existence of lumina collapse or twisting
* severe arrhythmia, myocardial ischemia or hypertensive crisis
* coagulation disorders
* existence of severe organ disfunction
* allergic to anesthesia drugs
* refuse to participate the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Changhai Hospital

OTHER

Sponsor Role collaborator

The First Affiliated Hospital of Guangzhou Medical University

OTHER

Sponsor Role collaborator

Xinqiao Hospital of Chongqing

OTHER

Sponsor Role collaborator

China Meitan General Hospital

OTHER

Sponsor Role collaborator

Micro-Tech (Nanjing) Co., Ltd.

INDUSTRY

Sponsor Role collaborator

Tang-Du Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Faguang Jin, PhD

Role: PRINCIPAL_INVESTIGATOR

Tang-Du Hospital

Locations

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Tangdu Hospital

Xi'an, Shaanxi, China

Site Status

Countries

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China

Central Contacts

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Deguang Mu, PhD

Role: CONTACT

86-29-84777825

Yandong Nan, MD

Role: CONTACT

86-29-84717533

Facility Contacts

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Deguang Mu, Ph.D

Role: primary

86-29-84777825

Other Identifiers

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NO.201402024

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

CAO-NO.201402024-benign

Identifier Type: -

Identifier Source: org_study_id