Slide Tracheoplasty Versus Tracheal Resection Anastomosis in Acquired Tracheal Stenosis

NCT ID: NCT06917222

Last Updated: 2025-09-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-01

Study Completion Date

2026-08-01

Brief Summary

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Aim of the Work To compare the clinical outcomes between patients will undergo slide tracheoplasty and those will undergo tracheal resection anastomosis for acquired tracheal stenosis.

Detailed Description

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Conditions

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Tracheal Stenosis Subglottic Stenosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Slide tracheoplasty

Group Type EXPERIMENTAL

Slide tracheoplasty

Intervention Type PROCEDURE

Management of tracheal stenosis by slide tracheoplasty

Tracheal resection anastomosis

Group Type EXPERIMENTAL

Tracheal resection anastomosis

Intervention Type PROCEDURE

Management of tracheal stenosis by tracheal resection anastomosis

Interventions

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Slide tracheoplasty

Management of tracheal stenosis by slide tracheoplasty

Intervention Type PROCEDURE

Tracheal resection anastomosis

Management of tracheal stenosis by tracheal resection anastomosis

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* All patients with grade III, IV acquired tracheal stenosis (e.g., due to trauma, prolonged intubation) regardless their age or sex.

* Patient with symptomatic high grade II acquired laryngotracheal stenosis after failure of endoscopic interventions.
* Clinical indications for surgical intervention (Symptoms of airway obstruction).
* Feasible for surgical intervention.

Exclusion Criteria

* congenital tracheal stenosis

* Malignant stenosis.
* Severe comorbidities that contraindicate the surgery.
* Patients refusing to sign the consent.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mansoura University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Eslam Hamed Elsayed Abdou

Assistant lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Eslam Hamed

Al Mansurah, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Eslam Hamed Abdou, Assistant lecturer

Role: CONTACT

+201015566532

Ahmed Elsobki, Associated professor

Role: CONTACT

+20 122 7505929

Facility Contacts

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Abdou

Role: primary

+201015566532

References

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Bocage JP, Caccavale R, Lewis R, Sisler G, MacKenzie J. Tracheal stenosis. N J Med. 1990 Aug;87(8):631-4.

Reference Type BACKGROUND
PMID: 2395535 (View on PubMed)

de Alarcon A, Rutter MJ. Cervical slide tracheoplasty. Arch Otolaryngol Head Neck Surg. 2012 Sep;138(9):812-6. doi: 10.1001/archoto.2012.1768.

Reference Type BACKGROUND
PMID: 22986713 (View on PubMed)

Freitag L, Darwiche K. Endoscopic treatment of tracheal stenosis. Thorac Surg Clin. 2014 Feb;24(1):27-40. doi: 10.1016/j.thorsurg.2013.10.003.

Reference Type BACKGROUND
PMID: 24295657 (View on PubMed)

Grillo HC. Surgical treatment of postintubation tracheal injuries. J Thorac Cardiovasc Surg. 1979 Dec;78(6):860-75.

Reference Type BACKGROUND
PMID: 502569 (View on PubMed)

Li C, Rutter MJ. Acquired tracheal stenosis: Cervical slide tracheoplasty. Semin Pediatr Surg. 2021 Jun;30(3):151058. doi: 10.1016/j.sempedsurg.2021.151058. Epub 2021 May 25.

Reference Type BACKGROUND
PMID: 34172213 (View on PubMed)

Manning PB, Rutter MJ, Lisec A, Gupta R, Marino BS. One slide fits all: the versatility of slide tracheoplasty with cardiopulmonary bypass support for airway reconstruction in children. J Thorac Cardiovasc Surg. 2011 Jan;141(1):155-61. doi: 10.1016/j.jtcvs.2010.08.060. Epub 2010 Nov 5.

Reference Type BACKGROUND
PMID: 21055774 (View on PubMed)

Schweiger C, Cohen AP, Rutter MJ. Tracheal and bronchial stenoses and other obstructive conditions. J Thorac Dis. 2016 Nov;8(11):3369-3378. doi: 10.21037/jtd.2016.11.74.

Reference Type BACKGROUND
PMID: 28066618 (View on PubMed)

Smith MM, Cotton RT. Diagnosis and management of laryngotracheal stenosis. Expert Rev Respir Med. 2018 Aug;12(8):709-717. doi: 10.1080/17476348.2018.1495564. Epub 2018 Jul 12.

Reference Type BACKGROUND
PMID: 29969925 (View on PubMed)

Tsang V, Murday A, Gillbe C, Goldstraw P. Slide tracheoplasty for congenital funnel-shaped tracheal stenosis. Ann Thorac Surg. 1989 Nov;48(5):632-5. doi: 10.1016/0003-4975(89)90777-7.

Reference Type BACKGROUND
PMID: 2818051 (View on PubMed)

Zalzal HG, Behzadpour HK, Leonard J, Sinha P, Preciado DA. Systematic Review of Slide Tracheoplasty Outcomes. Ann Otol Rhinol Laryngol. 2023 May;132(5):558-565. doi: 10.1177/00034894221104955. Epub 2022 Jun 20.

Reference Type BACKGROUND
PMID: 35723210 (View on PubMed)

Other Identifiers

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Slide tracheoplasty

Identifier Type: -

Identifier Source: org_study_id

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