TACE Treats Nodular Goiter

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-01

Study Completion Date

2027-09-01

Brief Summary

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transarterial bleomycin chemoembolization represents a novel minimally invasive therapeutic approach for the management of giant nodular goiter.

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Detailed Description

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Conditions

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Nodular Goiter

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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TACE

Group Type EXPERIMENTAL

TACE

Intervention Type PROCEDURE

TACE, 15,000U bleomycin and 200-400μm drug-loaded microspheres

Interventions

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TACE

TACE, 15,000U bleomycin and 200-400μm drug-loaded microspheres

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Clinical criteria: thyroid enlargement, mostly painless, with compressive symptoms (such as dysphagia, dyspnea) being less common; thyroid function is mostly normal, and a small number may be accompanied by hyperthyroidism or hypothyroidism.
* Imaging examinations: ultrasound shows multiple solid or cystic-solid nodules with clear boundaries and no malignant signs such as microcalcification and a vertical-to-horizontal diameter ratio \>1.
* Pathological criteria: follicular epithelial cell hyperplasia, no nuclear atypia, and no malignant cellular characteristics (such as mitotic figures, infiltrative growth, etc.). In this study, a thyroid goiter with at least one diameter exceeding 4 cm was considered a giant goiter

Exclusion Criteria

* abnormal coagulation profiles;
* hepatic or renal impairment;
* allergy to contrast media;
* refusal of interventional therapy and requirement for surgical treatment or other therapies

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No