Perioperative Complications After Neoadjuvant Radiotherapy for Colorectal Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-18

Study Completion Date

2026-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Neoadjuvant radiotherapy plays an important role in the treatment of locally advanced colorectal cancer. Although radiation therapy is extremely important in reducing the tumor mass, downstaging, and therefore providing conditions for curative surgery, neoadjuvant therapy can increase the risk of perioperative complications, which can lead to slower patient recovery, greater perioperative morbidity, prolonged hospitalization, and increased treatment costs.

The aim of the study is to determine whether there is a difference in the incidence of perioperative complications after radical colorectal cancer surgery between patients who received neoadjuvant radiotherapy and those patients who did not undergo neoadjuvant radiation.

Data is collected from the medical documentation and information system of the Oncology Institute of Vojvodina. Demographic characteristics of patients, comorbidities, length of hospital stay, length of treatment in the intensive care unit, occurrence of complications in the perioperative period, as well as data on neoadjuvant therapy are analyzed. All included patients are of similar general condition, as determined by the CFS (Clinical Frailty Scale). Intraoperative complications are graded using the ClassIntra classification of intraoperative adverse events, and the presence of postoperative adverse events are assessed and classified using the Clavien-Dindo classification of postoperative complications and the HARM (HospitAl stay, Readmission, Mortality rate) score.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Iron-deficiency Anaemia and Its Impact on Recovery After Colorectal Cancer Surgery

NCT06276140

Iron Deficiencies Iron Deficiency Anaemia Postoperative Complications +1 more

ENROLLING_BY_INVITATION

Risk Factor Assessment for the Development of Surgical Site Infection in Patients Undergoing Colorectal Cancer Surgery

NCT07104903

Surgical Site Infections Colorectal Cancer

COMPLETED

Role of Indexed Oxygen Delivery in Anastomotic Insufficiencies in Elective Laparoscopic Colorectal Resections for Cancer

NCT07099820

Anastomosis; Complications Anastomosis, Surgical Anastomosis, Leaking +8 more

RECRUITING

Organ/Space Surgical Site Infection and Recurrence and Survival in Rectal Cancer Surgery

NCT06382415

Rectal Cancer Organ-Space Surgical Site Infection

COMPLETED

Factors Affecting the Results of Treatment of Patients With Colorectal Cancer

NCT06050447

Colorectal Cancer Colon Cancer Rectal Cancer +3 more

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Colorectal Cancer Neoadjuvant Radiotherapy Perioperative Complication

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Neoadjuvant radiotherapy group

Patients who underwent radiotherapy before the surgical treatment of colorectal cancer

No interventions assigned to this group

Control group

Patients who did not undergo radiotherapy before the surgical treatment of colorectal cancer

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adult patients (over 18 years of age)
* Clinical Frailty Scale 2, 3 or 4 status
* Patients undergoing radical surgical treatment of colorectal cancer