A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

NCT ID: NCT07219173

Last Updated: 2026-01-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2

Total Enrollment

531 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-10-22

Study Completion Date

2028-06-30

Brief Summary

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The purpose of this study is to assess the safety and efficacy of brenipatide at different dose levels compared with placebo in participants with moderate-to-severe asthma.

Study participation will last approximately 65 weeks, including screening, treatment, and follow-up periods.

Detailed Description

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Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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Brenipatide Dose 1

Brenipatide administered subcutaneously (SC)

Group Type EXPERIMENTAL

Brenipatide

Intervention Type DRUG

Administered SC

Brenipatide Dose 2

Brenipatide administered SC.

Group Type EXPERIMENTAL

Brenipatide

Intervention Type DRUG

Administered SC

Placebo

Placebo administered SC.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Administered SC

Interventions

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Brenipatide

Administered SC

Intervention Type DRUG

Brenipatide

Administered SC

Intervention Type DRUG

Placebo

Administered SC

Intervention Type DRUG

Other Intervention Names

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LY3537031 LY3537031

Eligibility Criteria

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Inclusion Criteria

* Physician-diagnosed asthma who have received a physician-prescribed asthma controller medication for at least 12 months prior to screening visit.
* Participants must have an asthma control questionnaire-6 (ACQ-6) score of ≥1.5 on 2 out of 3 visits before randomization.
* History of 1 severe asthma exacerbation that led to systemic glucocorticoid treatment in the last 12 months prior to screening visit.

Exclusion Criteria

* Participants are excluded from the study if any of the following criteria apply:

* An established diagnosis of occupational asthma
* Known pre-existing, clinically important lung condition other than asthma, including but not limited to:

* chronic respiratory infection
* bronchiectasis
* pulmonary fibrosis
* allergic bronchopulmonary aspergillosis
* emphysema
* chronic bronchitis
* eosinophilic granulomatosis with polyangiitis
* chronic obstructive pulmonary disease, and
* other mimics of asthma, that is, vocal cord dysfunction.
* Have a current or recent acute, active infection. For at least 30 days before screening visit and up to the randomization visit.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-45 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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AMR Clinical

Tempe, Arizona, United States

Site Status RECRUITING

NewportNativeMD, Inc.

Newport Beach, California, United States

Site Status RECRUITING

California Medical Research Associates

Northridge, California, United States

Site Status RECRUITING

Peninsula Research Associates

Rolling Hills Estates, California, United States

Site Status RECRUITING

Asthma & Allergy Associates - Colorado Springs

Colorado Springs, Colorado, United States

Site Status RECRUITING

AMR Clinical

Doral, Florida, United States

Site Status RECRUITING

Renstar Medical Research

Ocala, Florida, United States

Site Status RECRUITING

Avanza Medical Research Center

Pensacola, Florida, United States

Site Status RECRUITING

USF Health

Tampa, Florida, United States

Site Status NOT_YET_RECRUITING

Axis Clinical Trials - Westchester

Westchester, Illinois, United States

Site Status RECRUITING

Allergy & Asthma Specialists, P.S.C.

Owensboro, Kentucky, United States

Site Status RECRUITING

Brigham and Women's Hospital

Boston, Massachusetts, United States

Site Status NOT_YET_RECRUITING

AMR Clinical

Las Vegas, Nevada, United States

Site Status RECRUITING

Equity Medical

New York, New York, United States

Site Status RECRUITING

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

Site Status NOT_YET_RECRUITING

Allergy and Clinical Immunology Associates

Pittsburgh, Pennsylvania, United States

Site Status RECRUITING

Vanderbilt Asthma, Sinus and Allergy Program

Nashville, Tennessee, United States

Site Status NOT_YET_RECRUITING

Consultorios Médicos, Organización del Buen Ayre S.R.L.

Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

Centro de Investigaciones Metabólicas (CINME)

Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

Fundación Respirar

Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

IDIM - Instituto de Investigaciones Metabólicas

Ciudad de Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

Instituto de Asma, Alergia y Enfermedades Respiratorias

Corrientes, , Argentina

Site Status NOT_YET_RECRUITING

Centro de Investigaciones Clínicas Baigorria

Granadero Baigorria, , Argentina

Site Status NOT_YET_RECRUITING

Instituto de Investigaciones Clínicas Mar del Plata

Mar del Plata, , Argentina

Site Status NOT_YET_RECRUITING

Instituto Médico Río Cuarto

Río Cuarto, , Argentina

Site Status NOT_YET_RECRUITING

ABC Instituto de Diagnóstico

Rosario, , Argentina

Site Status NOT_YET_RECRUITING

Ibamedica

Santa Fe, , Argentina

Site Status NOT_YET_RECRUITING

NewData Clinical Research - Aracaju

Aracaju, , Brazil

Site Status NOT_YET_RECRUITING

Private Practice - Dr. Nelson Rosário

Curitiba, , Brazil

Site Status NOT_YET_RECRUITING

Clinica de Pneumologia

Goiânia, , Brazil

Site Status NOT_YET_RECRUITING

Centro de Pesquisa Clínica de Marília - CPCLIM

Marília, , Brazil

Site Status NOT_YET_RECRUITING

Hospital Universitário Onofre Lopes

Natal, , Brazil

Site Status NOT_YET_RECRUITING

Instituto Atena de Pesquisa Clinica

Natal, , Brazil

Site Status NOT_YET_RECRUITING

Instituto Méderi de Pesquisa e Saúde

Passo Fundo, , Brazil

Site Status NOT_YET_RECRUITING

Hospital de Clínicas de Ribeirão Preto

Ribeirão Preto, , Brazil

Site Status NOT_YET_RECRUITING

IBPClin - Instituto Brasil de Pesquisa Clínica

Rio de Janeiro, , Brazil

Site Status NOT_YET_RECRUITING

Clinica de Alergia Martti Antila

Sorocaba, , Brazil

Site Status NOT_YET_RECRUITING

Dynamic Drug Advancement

Ajax, , Canada

Site Status NOT_YET_RECRUITING

Heritage Medical Research Clinic

Calgary, , Canada

Site Status NOT_YET_RECRUITING

University Of Alberta Hospital

Edmonton, , Canada

Site Status SUSPENDED

St. Joseph's Healthcare Hamilton

Hamilton, , Canada

Site Status NOT_YET_RECRUITING

Kelowna Health and Memory Centre

Kelowna, , Canada

Site Status NOT_YET_RECRUITING

McGill University Health Centre

Montreal, , Canada

Site Status NOT_YET_RECRUITING

IUCPQ

Québec, , Canada

Site Status NOT_YET_RECRUITING

Richmond Clinical Trials

Richmond, , Canada

Site Status RECRUITING

C.I.C. Saint-Laurent

Saint-Laurent, , Canada

Site Status NOT_YET_RECRUITING

Inspiration Research

Toronto, , Canada

Site Status NOT_YET_RECRUITING

Dr. Syed Anees Medicine Professional Corporation

Windsor, , Canada

Site Status RECRUITING

The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technolo -T

Baotou, , China

Site Status NOT_YET_RECRUITING

Beijing Chaoyang Hospital, Capital Medical University

Beijing, , China

Site Status NOT_YET_RECRUITING

West China Hospital, Sichuan University

Chengdu, , China

Site Status NOT_YET_RECRUITING

The First Affiliated Hospital of Chongqing Medical University

Chongqing, , China

Site Status NOT_YET_RECRUITING

Zhejiang Provincial People's Hospital

Hangzhou, , China

Site Status NOT_YET_RECRUITING

Jiangxi Provincial People's Hospital

Nanchang, , China

Site Status NOT_YET_RECRUITING

Nanjing Medical University - Nanjing Jiangning Hospital

Nanjing, , China

Site Status NOT_YET_RECRUITING

Shanghai General Hospital

Shanghai, , China

Site Status NOT_YET_RECRUITING

The University of Hong Kong-Shenzhen Hospital

Shenzhen, , China

Site Status NOT_YET_RECRUITING

The Second Afilliated Hospital of Hebei Medical University

Shijiazhuang, , China

Site Status NOT_YET_RECRUITING

Tianjin Medical University General Hospital

Tianjin, , China

Site Status NOT_YET_RECRUITING

The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University

Wenzhou, , China

Site Status NOT_YET_RECRUITING

Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology

Wuhan, , China

Site Status NOT_YET_RECRUITING

Centre Hospitalier du Pays dAix - Centre Hospitalier Intercommunal Aix-Pertuis - Site d'Aix en Provence

Aix-en-Provence, , France

Site Status NOT_YET_RECRUITING

CHRU de Brest

Brest, , France

Site Status NOT_YET_RECRUITING

Centre Hospitalier de Cholet

Cholet, , France

Site Status NOT_YET_RECRUITING

Centre Hospitalier de Versailles André Mignot

Le Chesnay, , France

Site Status NOT_YET_RECRUITING

Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre

Le Kremlin-Bicêtre, , France

Site Status NOT_YET_RECRUITING

Groupe Hospitalier Intercommunal Le Raincy-Montfermeil

Montfermeil, , France

Site Status NOT_YET_RECRUITING

Hôpital Bichat - Claude-Bernard

Paris, , France

Site Status NOT_YET_RECRUITING

CHU Bordeaux Haut-Leveque

Pessac, , France

Site Status NOT_YET_RECRUITING

Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou

Rennes, , France

Site Status NOT_YET_RECRUITING

Hôpital Foch

Suresnes, , France

Site Status NOT_YET_RECRUITING

KPPK Studienzentrum

Bendorf, , Germany

Site Status NOT_YET_RECRUITING

Studienpraxis Berlin-Brandenburg Lennart Schaper

Berlin, , Germany

Site Status NOT_YET_RECRUITING

Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen

Essen, , Germany

Site Status NOT_YET_RECRUITING

IKF Pneumologie Frankfurt, Clinical Research Center, Departments: Pulmonology, Endocrinology, Cardiovascul -T

Frankfurt, , Germany

Site Status NOT_YET_RECRUITING

ME Clinical Respiratory Research Hamburg

Hamburg, , Germany

Site Status NOT_YET_RECRUITING

POIS Sachsen

Leipzig, , Germany

Site Status NOT_YET_RECRUITING

IKF Pneumologie Mainz

Mainz, , Germany

Site Status NOT_YET_RECRUITING

Dedicated Research Site FutureMeds

Offenbach, , Germany

Site Status NOT_YET_RECRUITING

Galaxy Superspeciality Hospital

Aurangabad, , India

Site Status NOT_YET_RECRUITING

Mahatma Gandhi Mission Medical College

Aurangabad, , India

Site Status NOT_YET_RECRUITING

Medstar Speciality Hospital

Bangalore, , India

Site Status NOT_YET_RECRUITING

All India Institute of Medical Sciences

Bhubaneswar, , India

Site Status NOT_YET_RECRUITING

Aakash Healthcare Private Limited

Dwārka, , India

Site Status NOT_YET_RECRUITING

Atmaram Child Care

Kanpur, , India

Site Status NOT_YET_RECRUITING

All India Institute of Medical Sciences

New Delhi, , India

Site Status NOT_YET_RECRUITING

Lifepoint Multispeciality Hospital

Pune, , India

Site Status NOT_YET_RECRUITING

All India Institute of Medical Sciences

Raipur, , India

Site Status NOT_YET_RECRUITING

Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences

Rohtak, , India

Site Status NOT_YET_RECRUITING

Tokyo-Eki Center-building Clinic

Chūōku, , Japan

Site Status NOT_YET_RECRUITING

Osaka Habikino Medical Center

Habikino, , Japan

Site Status NOT_YET_RECRUITING

Aso Iizuka Hospital

Iizuka, , Japan

Site Status NOT_YET_RECRUITING

Kagoshima University Hospital

Kagoshima, , Japan

Site Status NOT_YET_RECRUITING

Ishikawa Prefectural Central Hospital

Kanazawa, , Japan

Site Status NOT_YET_RECRUITING

Kameari Internal Medicine and Respiratory Clinic

Katsushika-ku, , Japan

Site Status NOT_YET_RECRUITING

Japan Community Healthcare Organization Chukyo Hospital

Nagoya, , Japan

Site Status NOT_YET_RECRUITING

Okayama University Hospital

Okayama, , Japan

Site Status NOT_YET_RECRUITING

National Hospital Organization Okayama Medical Center

Okayama, , Japan

Site Status NOT_YET_RECRUITING

Osaka Metropolitan University Hospital

Osaka, , Japan

Site Status NOT_YET_RECRUITING

Kanagawa Cardiovascular and Respiratory Center

Yokohama, , Japan

Site Status NOT_YET_RECRUITING

San Peregrino Unidad de Investigación

Aguascalientes, , Mexico

Site Status NOT_YET_RECRUITING

Scientia Investigacion Clinica S.C.

Chihuahua City, , Mexico

Site Status NOT_YET_RECRUITING

Instituto de Investigaciones Aplicadas a la Neurociencia A.C.

Durango, , Mexico

Site Status NOT_YET_RECRUITING

Instituto Jalisciense de Investigación Clínica Sa de Cv

Guadalajara, , Mexico

Site Status NOT_YET_RECRUITING

Clinica de Investigacion en Reumatologia y Obesidad S. C.

Guadalajara, , Mexico

Site Status NOT_YET_RECRUITING

Centro de Desarrollo Biomedico

Mérida, , Mexico

Site Status NOT_YET_RECRUITING

Kohler & Milstein Research S.A. De C.V.

Mérida, , Mexico

Site Status NOT_YET_RECRUITING

Cicmex Centro de Investigación Clínica de México

Morelia, , Mexico

Site Status NOT_YET_RECRUITING

Centro de Investigacion Clinica Chapultepec

Querétaro, , Mexico

Site Status NOT_YET_RECRUITING

FAICIC S. de R.L. de C.V.

Veracruz, , Mexico

Site Status NOT_YET_RECRUITING

EB Medical Research

Almere Stad, , Netherlands

Site Status NOT_YET_RECRUITING

Amphia Ziekenhuis, locatie Breda Molengracht

Breda, , Netherlands

Site Status NOT_YET_RECRUITING

Canisius-Wilhelmina Ziekenhuis

Nijmegen, , Netherlands

Site Status NOT_YET_RECRUITING

Franciscus Gasthuis & Vlietland, Locatie Gasthuis

Rotterdam, , Netherlands

Site Status NOT_YET_RECRUITING

Gelre Ziekenhuizen

Zutphen, , Netherlands

Site Status NOT_YET_RECRUITING

Isala, locatie Zwolle

Zwolle, , Netherlands

Site Status NOT_YET_RECRUITING

Centrum Medyczne ,,All - Med'' Badania Kliniczne

Krakow, , Poland

Site Status NOT_YET_RECRUITING

Diamond Clinic

Krakow, , Poland

Site Status NOT_YET_RECRUITING

Alergologia Plus sp. z o.o.

Poznan, , Poland

Site Status NOT_YET_RECRUITING

Specjalistyczna Przychodnia Lekarska Alergo-Med Sp. z o.o

Poznan, , Poland

Site Status NOT_YET_RECRUITING

Countries

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United States Argentina Brazil Canada China France Germany India Japan Mexico Netherlands Poland

Central Contacts

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Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

Role: CONTACT

317-615-4559

Physicians interested in becoming principal investigators please contact

Role: CONTACT

Facility Contacts

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Role: primary

602-910-3343

Role: primary

949-791-8599

Role: primary

310-265-1623

Role: primary

352-629-5800

Role: primary

850-477-7900

Role: primary

813-631-4024

Role: primary

270-684-6144

Role: primary

702-597-9825

Role: primary

630-981-1261

Role: primary

412-833-4051

Role: primary

+541168893232

Role: primary

08003450697

Role: primary

+549115 800 5058

Role: primary

541154143028

Role: primary

+5493794391031

Role: primary

+5493416008195

Role: primary

+54 9 2234 24-0652

Role: primary

541131077237

Role: primary

54 341 397379

Role: primary

543424564943

Role: primary

5541 3208 6500

Role: primary

+552125277979

Role: primary

551535194909

Role: primary

3658859086

Role: primary

604-373-4954

Role: primary

4169449602

Role: primary

(519) 252-4448

Role: primary

13101363078

Role: primary

13576030963

Role: primary

13132088076

Role: primary

0661073507

Role: primary

0141708160

Role: primary

0684629275

Role: primary

+330557656039

Role: primary

004926228983390

Role: primary

+493044048226

Role: primary

00492014334503

Role: primary

4969695972580

Role: primary

0049 40 46095194

Role: primary

034160050650

Role: primary

004969247419600

Role: primary

+91-8390628800

Role: primary

09910425552

Role: primary

+91-9028560535

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

4491114337

Role: primary

3331200700

Role: primary

9992855178

Role: primary

529999204004

Role: primary

2299327808

Role: primary

0031365468346

Role: primary

0031-76-5952383

Role: primary

0243658755

Role: primary

0104616619

Role: primary

+31575592322

Role: primary

0031 88 6243254

Role: primary

48124223271

Role: primary

+ 48 696 049 029

Role: primary

+48616562160

Role: primary

+48 601 751 713

Other Identifiers

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2025-522640-41

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

J2S-MC-GZMR

Identifier Type: OTHER

Identifier Source: secondary_id

27744

Identifier Type: -

Identifier Source: org_study_id

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