Comparison of Transcutaneous and Arterial Carbon Dioxide Sampling During Jet Ventilation, a Prospective. Study on Patients Undergoing Percutaneous Liver Tumour Radiofrequency Ablation

NCT ID: NCT07211763

Last Updated: 2025-10-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-04-01

Study Completion Date

2026-07-31

Brief Summary

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The study aims to compare the readings from two methods of monitoring carbon dioxide levels during jet ventilation when normal end-tidal monitoring is not possible. During jet ventilation it is technically not possible to monitor the levels of carbon dioxide in exhaled air as is the standard in preoperative care. We will compare transcutaneous (through the skin) monitoring to an arterial blood. sample. Both transcutaneous monitoring and arterial monitoring is currently used as the standard for this patient group at our institution. By collecting data prospectively we can evaluate if there. are discrepancies based on monitoring method. All patients will be treated per standard preoperative protocol and only patients consenting to participate will contribute data to the comparison and statistical analysis.

Detailed Description

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During percutaneous radio frequency ablation of liver tumours, jet. ventilation is used to minimise diaphragm movement. By not having conventional ventilation the interventional radiologist have better conditions to perform the treatment and minimising risk damaging adjacent tissue. Jet ventilation does however remove the possibility to monitor end tidal CO2, necessitating alternative monitoring to ensure adequate ventilation. At our institution we use transcutaneous and arterial blood gas monitoring. We aim to collect data on both modalities and compare the values using a "repeat measure Bland-Altmann" analysis.

Study participants will be managed as per normal protocol and the only difference to the non-participators will be their contribution of prospective data for later analysis.

Conditions

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Liver Ablation High Frequency Jet Ventilation

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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jet_ventilation

No Interventions

Intervention Type OTHER

No intervention, solely data collection

Interventions

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No Interventions

No intervention, solely data collection

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* adult patients undergoing percutaneous RF liver tumour ablation requiring jet ventilation

Exclusion Criteria

* disease or condition. not compatible with jet ventilation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sahlgrenska University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Fredrik Olsen

MD PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Fredrik Olsen, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Sahlgrenska University Hospital

Locations

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Sahlgrenska University Hospital

Gothenburg, , Sweden

Site Status RECRUITING

Countries

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Sweden

Central Contacts

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Fredrik Olsen, MD PhD

Role: CONTACT

+46 313428169

Carl Hallgren, MD

Role: CONTACT

+460313430286

Facility Contacts

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Fredrik Olsen, MD PhD

Role: primary

+463134328169

Other Identifiers

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LiverJet

Identifier Type: -

Identifier Source: org_study_id

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