Effect of Theta-burst rTMS Therapy on the Clinical and Cognitive Symptoms of Patients With Therapy Resistant Depression and Response Prediction With Neuroimaging Methods.
NCT ID: NCT07207239
Last Updated: 2025-10-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
NA
54 participants
INTERVENTIONAL
2025-06-13
2028-06-13
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
SCREENING
NONE
Study Groups
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TB-rTMS
repetative Transcranial Magnetic Stimulation (rTMS), theta-burst protocol
Theta-burst rTMS treatment stimulates the left Dorsolateral Prefrontal Cortex (DLPFC). The TBS parameters the investigators adopted follows the standard TBS protocols, with 3-pulse 50-Hz bursts given every 200 ms (at 5 Hz) and an intensity of 100% active motor threshold. The investigators plan to deliver 1800 stimuli to the left DLPFC daily in 9.5-minute blocks for four weeks.
Interventions
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repetative Transcranial Magnetic Stimulation (rTMS), theta-burst protocol
Theta-burst rTMS treatment stimulates the left Dorsolateral Prefrontal Cortex (DLPFC). The TBS parameters the investigators adopted follows the standard TBS protocols, with 3-pulse 50-Hz bursts given every 200 ms (at 5 Hz) and an intensity of 100% active motor threshold. The investigators plan to deliver 1800 stimuli to the left DLPFC daily in 9.5-minute blocks for four weeks.
Eligibility Criteria
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Inclusion Criteria
2. 18 years of age
3. Beck depression inventory score above 12 (screening)
4. MADRS score above 6 (baseline)
Exclusion Criteria
2. mental retardation
3. history of head injury with loss of consciousness for more than 1 hour
4. alcohol or drug abuse within the past 3 months
18 Years
ALL
No
Sponsors
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Semmelweis University
OTHER
Responsible Party
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Gábor Csukly
Associate Professor
Locations
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Department of Psychiatry and Psychotherapy
Budapest, Pest County, Hungary
Countries
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Other Identifiers
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TMS-DEP-2024
Identifier Type: -
Identifier Source: org_study_id
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