Oral Versus Intravenous Acetaminophen in Lumbar Spine Surgery
NCT ID: NCT07203079
Last Updated: 2025-10-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
PHASE4
180 participants
INTERVENTIONAL
2026-01-31
2027-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Oral Acetaminophen 1000mg
Participants take oral acetaminophen and placebo infusion for 48 hours within 2 hours after their spine surgery
Acetaminophen Oral Tablet
Participants take 1000mg by mouth every 6 hours for a total of 8 doses (48 hours total) starting within 2 hours after their spine surgery.
Placebo infusion
Participants take 1000mg placebo by intravenous infusion over 15 minutes every 6 hours for a total of 8 doses (48 hours total) starting within 2 hours after their spine surgery.
Intravenous Acetaminophen 1000mg
Participants take acetaminophen infusion and oral placebo for 48 hours within 2 hours after their spine surgery
placebo oral tablet
Participants take one placebo tablet (matchable to tylenol) by mouth every 6 hours for a total of 8 doses (48 hours total) starting within 2 hours after their spine surgery.
Acetaminophen infusion
Participants take 1000mg by intravenous infusion over 15 minutes every 6 hours for a total of 8 doses (48 hours total) starting within 2 hours after their spine surgery.
Interventions
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Acetaminophen Oral Tablet
Participants take 1000mg by mouth every 6 hours for a total of 8 doses (48 hours total) starting within 2 hours after their spine surgery.
placebo oral tablet
Participants take one placebo tablet (matchable to tylenol) by mouth every 6 hours for a total of 8 doses (48 hours total) starting within 2 hours after their spine surgery.
Acetaminophen infusion
Participants take 1000mg by intravenous infusion over 15 minutes every 6 hours for a total of 8 doses (48 hours total) starting within 2 hours after their spine surgery.
Placebo infusion
Participants take 1000mg placebo by intravenous infusion over 15 minutes every 6 hours for a total of 8 doses (48 hours total) starting within 2 hours after their spine surgery.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Able to provide written informed consent
* Must be able to swallow pills
Exclusion Criteria
* Emergency surgery
* Chronic pain unrelated to surgery
* Pregnancy
18 Years
ALL
No
Sponsors
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Stanford University
OTHER
Responsible Party
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Atman Desai
Professor of Neurosurgery
Principal Investigators
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Atman Desai, MD
Role: PRINCIPAL_INVESTIGATOR
Stanford University
Locations
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Stanford University
Stanford, California, United States
Countries
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Other Identifiers
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82641
Identifier Type: -
Identifier Source: org_study_id
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