Regenerative Potentials of Mature Mandibular Molars With Symptomatic Irreversible Pulpitis Enhanced With Different Scaffolds
NCT ID: NCT07196683
Last Updated: 2025-10-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
75 participants
INTERVENTIONAL
2025-11-01
2027-11-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Ascorbic acid augmented PRF scaffold
Regenerative pulpotomy
Regenerative pulpotomy combines the use of hydraulic calcium silicate based cements; MTA, together with biodegradable scaffolds such as PRF.
Tannic acid cross linked PRF scaffold
Regenerative pulpotomy
Regenerative pulpotomy combines the use of hydraulic calcium silicate based cements; MTA, together with biodegradable scaffolds such as PRF.
PRF scaffold
Regenerative pulpotomy
Regenerative pulpotomy combines the use of hydraulic calcium silicate based cements; MTA, together with biodegradable scaffolds such as PRF.
Interventions
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Regenerative pulpotomy
Regenerative pulpotomy combines the use of hydraulic calcium silicate based cements; MTA, together with biodegradable scaffolds such as PRF.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age between 15-40 years.
* Males \& Females.
* Patients' acceptance to participate in the trial.
* Patients who can understand pain scale and can sign the informed consent (Appendix I).
* Mature mandibular fist molars:
* Diagnosed clinically with symptomatic irreversible pulpitis and normal periapical tissue.
* Giving a positive response to pulp sensitivity testing.
* Having negative response to percussion.
* Having normal radiographic appearance of periapical tissues.
* Having bright red color of pulp tissue, with hemorrhage control within 10 mins, upon access cavity preparation.
Exclusion Criteria
* Patients with physical or mental handicapping conditions.
* Patients unwilling to participate in a 12-months follow up.
* Mandibular first molars with:
* Immature roots.
* Negative response to pulp sensitivity testing.
* Positive response to percussion.
* Radiographic evidence of periapical lesions, external or internal root resorption, vertical root fracture, or calcification.
* Intraoral swelling or fistula.
* Lack of pulpal bleeding, or inability to achieve hemostasis of the bleeding pulp within 10 mins, upon access cavity preparation.
15 Years
40 Years
ALL
No
Sponsors
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Cairo University
OTHER
Responsible Party
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Omnia Abdel Hakim
Assistant lecturer
Locations
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Faculty of Dentistry, Cairo University
Cairo, , Egypt
Countries
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Central Contacts
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Other Identifiers
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New ENDO 5-5-1
Identifier Type: -
Identifier Source: org_study_id
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