"Incidence of Compensatory Hyperhidrosis After T3 Vs T3-4 Sympathectomy"

NCT ID: NCT07196319

Last Updated: 2025-10-03

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 46 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-11-15
• Study Completion Date: 2028-10-25

Brief Summary

The goal of this study is to compare the proportion of compensatory hyperhidrosis patients after sympathectomy at T3 level and sympathectomy at T3-4 level. The main question it aims to answer is:

can sympathectomyv at one level decrease the incidence of compensatory hyperhidrosis after primary hyperhidrosis.

Detailed Description

Primary hyperhidrosis is a chronic condition characterized by excessive sweating beyond physiological needs, commonly affecting the palms, axillae, face, or soles. This disorder is largely attributed to neurogenic hyperexcitability within the sympathetic nervous system's pathways innervating the eccrine sweat glands.When conservative treatments such as topical agents or oral medications fail, endoscopic thoracic sympathectomy (ETS) is considered an effective surgical option. However, a major postoperative complication is compensatory hyperhidrosis (CH)-the development of excessive sweating in previously unaffected areas such as the trunk, back, or thighs. CH can significantly impact patient satisfaction and quality of life, often becoming more distressing than the original condition.

The extent and level of sympathectomy have been proposed as key factors influencing the incidence and severity of CH. While higher levels or multilevel resections (e.g., T2-4) are associated with increased rates of CH, more limited approaches such as T3-only resection are thought to reduce this risk. However, definitive evidence comparing T3 versus T3-4 sympathectomy remains limited and inconsistent across studies.

This study aims to compare the incidence and severity of compensatory hyperhidrosis following T3 versus T3-4 sympathectomy for primary hyperhidrosis. Understanding these differences may help refine surgical approaches to minimize CH and improve patient outcomes.

Conditions

Compensatory Hyperhidrosis; Compensatory Sweating

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

T3 sympathectomy

patients who underwent T3 sympathectomy for primary hyperhidrosis

No interventions assigned to this group

T3-4 sympathectomy

patients who underwent through T3-4 sympathectomy for primary hyperhidrosis

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Patients diagnosed with primary hyperhidrosis
• Patients with palmar and\or axillary hyperhidrosis.
• Age ≥ 6 years

Exclusion Criteria

• History of Prior thoracic surgery.
• History of prior disorder that cause hyperhidrosis ( obesity,autonomic neuropathy,menopause,gout,etc…)
• History of prior systemic diseases cause hyperhidrosis (hyperthyroidism,DM,pheochromocytoma,Parkinson's disease,etc…)
• Patients with psychological problems.

• Minimum Eligible Age: 6 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Mohamed Ahmed Abdelmoneim Ahmed

principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

References

Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009 Nov;41(4):1149-60. doi: 10.3758/BRM.41.4.1149.

Reference Type: BACKGROUND

PMID: 19897823 (View on PubMed)

Strutton DR, Kowalski JW, Glaser DA, Stang PE. US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey. J Am Acad Dermatol. 2004 Aug;51(2):241-8. doi: 10.1016/j.jaad.2003.12.040.

Reference Type: BACKGROUND

PMID: 15280843 (View on PubMed)

4. Lin TS, et al. Clinical experience of thoracoscopic sympathetic block for primary hyperhidrosis: analysis of 3450 cases. J Thorac Cardiovasc Surg. 2001;121(3):566-74.

Reference Type: BACKGROUND

3. Hussein AF, et al. Unilevel (T3) versus Bilevel (T3 - T4) Sympathictomy in the Management of Palmar Hyperhidrosis: A Prospective Comparative Study. Clinics (Sao Paulo). 2024.

Reference Type: BACKGROUND

2. Liu X, Wang J, Liu Z, Sun X, Zheng J. Comparison of only T3 and T3-T4 sympathectomy for axillary hyperhidrosis: a retrospective study. J Thorac Dis. 2018;10(4):2095-101.

Reference Type: BACKGROUND

Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007 May;39(2):175-91. doi: 10.3758/bf03193146.

Reference Type: BACKGROUND

PMID: 17695343 (View on PubMed)

Licht PB, Pilegaard HK. Severity of compensatory sweating after thoracoscopic sympathectomy. Ann Thorac Surg. 2004 Aug;78(2):427-31. doi: 10.1016/j.athoracsur.2004.02.087.

Reference Type: BACKGROUND

PMID: 15276490 (View on PubMed)

Other Identifiers

CH post T3 &T3-4 Sympathectomy

Identifier Type: -

Identifier Source: org_study_id