WAMIF: Prospective Study in Young Women Presenting Acute Myocardial Infarction: Cohort Follow up

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

314 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-11-25

Study Completion Date

2029-09-30

Brief Summary

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The WAMIF study was conducted from 2017 to 2019, including 314 patients in 30 French research centers spread across metropolitan France. It systematically collected the clinical, morphological, and biological characteristics of myocardial infarction cases affecting women under 50 years of age and assessed their short-term (in-hospital) and medium-term (12-month) prognosis. Extending the follow-up beyond 12 months for this first study would provide fundamental data for understanding and improving the care of these patients.

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Detailed Description

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The WAMIF study was conducted from 2017 to 2019, including 314 patients in 30 French research centers spread across metropolitan France. It systematically collected the clinical, morphological, and biological characteristics of myocardial infarction cases affecting women under 50 years of age and assessed their short-term (in-hospital) and medium-term (12-month) prognosis. The main results were: a particularly high incidence of modifiable risk factors affecting 86% of patients, with smoking being the primary cause in 75% of them.The clinical presentation found chest pain in more than 90% of cases. The pathophysiological forms of acute coronary syndrome identified the culprit artery in 90% of cases, a form without obstruction (MINOCA) was found in 17.8% of ST segment elevation infarctions (STEMI), spontaneous dissection in 14.6% of STEMI and 16.3% of NSTEMI.At 12 months, follow-up showed no cardiovascular deaths and two deaths related to neoplastic causes. At the end of this follow-up, 90% had no events. Compared to existing studies, these event rates are extremely low. Extending the follow-up beyond 12 months for this first study would provide fundamental data for understanding and improving the care of these patients. The secondary objective is the evaluation of the quality of life and mental health of women who have had an MI before the age of 50 years at a distance from the acute event.

Conditions

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Myocardial Infarction, Acute

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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WAMIF patients

All patients who participated in the WAMIF study (NCT 03073447) and wish to continue follow-up in the present "WAMIF-suivi" study.

Questionnaires

Intervention Type OTHER

Assessment of stress and anxiety and quality of life after myocardial infarct:

* Stress score: Perceived Stress Scale-4 (PSS-4)
* Anxiety score: Generalized Anxiety Disorder-7 (GAD-7)
* Depression score: Patient Health Questionnaire-9 (PHQ-9)
* Quality of life scores: European Quality of Life-5 Dimensions (EQ-5D) and 12-Item Short-Form General Health Survey (SF-12)

Major events

Intervention Type OTHER

Collection of information related to major events occurring since inclusion in the WAMIF study

Interventions

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Questionnaires

Assessment of stress and anxiety and quality of life after myocardial infarct:

* Stress score: Perceived Stress Scale-4 (PSS-4)
* Anxiety score: Generalized Anxiety Disorder-7 (GAD-7)
* Depression score: Patient Health Questionnaire-9 (PHQ-9)
* Quality of life scores: European Quality of Life-5 Dimensions (EQ-5D) and 12-Item Short-Form General Health Survey (SF-12)

Intervention Type OTHER

Major events

Collection of information related to major events occurring since inclusion in the WAMIF study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

All patients who participated in the WAMIF study (research registration number with the French Ministry of Health : 2015-A01263-46 / Protocol registration with Clinical Trials NCT03073447) and wish to continue follow-up in the study.

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No