Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

77 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-09-30

Study Completion Date

2010-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Prospective study including all the consecutive patients admitted at the Department of Cardiology, Timone Hospital wih a definite diagnosis of IE according to the modified Duke criteria. The period of inclusion will be for 24 months. Eighty patients and age-matched control subject will be included. Primary end point are EE occurring during the antimicrobial treatment and secondary end points will be 6-month mortality, vegetation length and the impact of antimicrobial treatment on inflammation-induced procoagulant changes and endothelial cell activation.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Prognostic Impact of Guideline-recommended Timing for Invasive Strategy in NSTEMI

NCT07204847

NSTEMI NSTE-ACS (NSTEMI and UA) NSTEMI - Non-ST-Segment Elevation Myocardial Infarction

COMPLETED

Impact of Ischemic Post-conditioning

NCT04068116

ST Elevation Myocardial Infarction Ventricular Remodeling Ventricular Dysfunction +1 more

UNKNOWN NA

The Relationship Between Myonectin Concentration and the Course of ST-segment Elevation Myocardial Infarction

NCT05700773

ST Elevation Myocardial Infarction

RECRUITING

Positive Effect of Ischemic Postconditioning During Acute Myocardial Infarction

NCT00333320

Acute Myocardial Infarction

COMPLETED PHASE1/PHASE2

Japan Unprotected Left Main Coronary Artery Disease Percutaneous Coronary Intervention (PCI) Strategy On New Generation Stents

NCT01256723

Coronary Artery Disease

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Infective Endocarditis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

patient

Group Type EXPERIMENTAL

ULTRASONOGRAPHY trans-esophageal and trans-thoracic , blood test and clinic test

Intervention Type OTHER

control

Group Type OTHER

ULTRASONOGRAPHY trans-esophageal and trans-thoracic , blood test and clinic test

Intervention Type OTHER

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

ULTRASONOGRAPHY trans-esophageal and trans-thoracic , blood test and clinic test

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* All the patients presenting certain diagnosis of infectious endocardite according to the criteria of modified Duke

Exclusion Criteria

* Age \< 18 years
* Pregnancy and feeding
* Health not allowing to give the assent
* Innate abnormalities of the haemostasis
* More than a week before the inclu antibiothérapie adapted begun

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes