Investigation of the Relationship Between Ultrasonographic Parameters and Tactile Sensation in Carpal Tunnel Syndrome

NCT ID: NCT07170449

Last Updated: 2025-09-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

84 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-08-01

Study Completion Date

2026-04-30

Brief Summary

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The aim of this study was to investigate the relationship between different ultrasonographic indices used in patients with carpal tunnel syndrome and the level of tactile sensation.

The primary questions the study aimed to answer are:

• To what extent are the ultrasonographic parameters used in the diagnosis of carpal tunnel syndrome related to the level of sensory complaints in the patient?

Detailed Description

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Carpal tunnel syndrome (CTS) is the most common compression neuropathy. The etiology of CTS can be related to work, lifestyle, injury, or genetic predisposition. Exposure to vibrations or repetitive forceful angular movements is among the most common causes of CTS. Certain diseases, such as diabetes, pregnancy, and morbidity, are also thought to be associated with an increased risk of developing CTS. It accounts for 90% of all entrapment neuropathies. Its prevalence in the population is between 1% and 5%, and it is three times more common in women. In CTS, complaints related to motor and sensory deficits are observed in the first three fingers innervated by the median nerve and the radial aspect of the fourth finger. Diagnosis is made by corroborating clinical signs and symptoms with electrophysiological findings. However, recently, ultrasound (US) is frequently preferred for the diagnosis of CTS to evaluate the morphological and mechanical properties of the median nerve. US is considered a highly accurate, effective, and cost-effective diagnostic method for the diagnosis of CTS, with a short evaluation time . Sonographic measurements related to CTS can yield values such as the diameter of the nerve at the entrance and exit of the tunnel. CTS presents with a disturbance in tactile input, such as numbness and loss of sensation in the median nerve dermatom. This sensory loss can cause difficulty in using the patient's hand in activities of daily living. Sonography has recently become widely used in CTS patients. The fact that values measured by sonography can provide information about the clinical status of patients can be considered important data for healthcare professionals. Therefore, our study was designed to examine the relationship between sonographic measurements and tactile sensory levels in patients diagnosed with mild to moderate CTS based on electrodiagnostic tests.

Conditions

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Carpal Tunnel Syndrome (CTS)

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Patient group

Patients with carpal tunnel syndrome

Nerve conduction studies

Intervention Type DIAGNOSTIC_TEST

Upper extremity nerve conduction studies including median-ulnar sensory and motor responses

Median nerve ultrasonography

Intervention Type DIAGNOSTIC_TEST

Median nerve sonographic cross-sectional area and echogenicity measurements

Sensory testing

Intervention Type DIAGNOSTIC_TEST

tactile sensory tests

Interventions

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Nerve conduction studies

Upper extremity nerve conduction studies including median-ulnar sensory and motor responses

Intervention Type DIAGNOSTIC_TEST

Median nerve ultrasonography

Median nerve sonographic cross-sectional area and echogenicity measurements

Intervention Type DIAGNOSTIC_TEST

Sensory testing

tactile sensory tests

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Electrodiagnostic diagnosis of carpal tunnel syndrome with pain, numbness, burning, and tingling consistent with the median nerve dermatomal area lasting at least 6 weeks.
* Literate
* Agree to participate in the study

Exclusion Criteria

* Concomitant diabetes, systemic inflammatory disease, active infection, and history of malignancy
* Being \<18 and \>65 years old
* Being illiterate
* Refusing to participate in the study
* Having a disease with neuropathic pain, such as polyneuropathy, radiculopathy, or MS
* Other concomitant upper extremity entrapment neuropathies (e.g., cubital tunnel syndrome)
* Having undergone surgery for carpal tunnel syndrome
* Rheumatoid arthritis, advanced hand osteoarthritis
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Müyesser Cavlak, PhD

Role: PRINCIPAL_INVESTIGATOR

Sultan Abdülhamit Han Trainin and Educatioal Hospital

Emre Ata, Assoc Prof

Role: STUDY_CHAIR

Sultan Abdülhamit Han Trainin and Educatioal Hospital

Locations

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Sultan Abdülhamit Han Trainin and Educational Hospital

Üsküdar, İ̇stanbul, Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Müyesser Cavlak, PhD

Role: CONTACT

+905426406118

Feyza Nur Yücel, Specialist

Role: CONTACT

5385577059 ext +90

Facility Contacts

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Müyesser Cavlak, PhD

Role: primary

+905426406118

References

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Bennett MI, Smith BH, Torrance N, Potter J. The S-LANSS score for identifying pain of predominantly neuropathic origin: validation for use in clinical and postal research. J Pain. 2005 Mar;6(3):149-58. doi: 10.1016/j.jpain.2004.11.007.

Reference Type BACKGROUND
PMID: 15772908 (View on PubMed)

Sezgin M, Incel NA, Serhan S, Camdeviren H, As I, Erdogan C. Assessment of symptom severity and functional status in patients with carpal tunnel syndrome: reliability and functionality of the Turkish version of the Boston Questionnaire. Disabil Rehabil. 2006 Oct 30;28(20):1281-5. doi: 10.1080/09638280600621469.

Reference Type BACKGROUND
PMID: 17083175 (View on PubMed)

Multanen J, Ylinen J, Karjalainen T, Ikonen J, Hakkinen A, Repo JP. Structural validity of the Boston Carpal Tunnel Questionnaire and its short version, the 6-Item CTS symptoms scale: a Rasch analysis one year after surgery. BMC Musculoskelet Disord. 2020 Sep 12;21(1):609. doi: 10.1186/s12891-020-03626-2.

Reference Type BACKGROUND
PMID: 32919457 (View on PubMed)

Stevens JC. AAEE minimonograph #26: The electrodiagnosis of carpal tunnel syndrome. Muscle Nerve. 1987 Feb;10(2):99-113. doi: 10.1002/mus.880100202.

Reference Type BACKGROUND
PMID: 3821791 (View on PubMed)

Fisse AL, Pitarokoili K, Motte J, Gamber D, Kerasnoudis A, Gold R, Yoon MS. Nerve echogenicity and intranerve CSA variability in high-resolution nerve ultrasound (HRUS) in chronic inflammatory demyelinating polyneuropathy (CIDP). J Neurol. 2019 Feb;266(2):468-475. doi: 10.1007/s00415-018-9158-3. Epub 2018 Dec 15.

Reference Type BACKGROUND
PMID: 30554264 (View on PubMed)

Wolny T, Linek P. Reliability of two-point discrimination test in carpal tunnel syndrome patients. Physiother Theory Pract. 2019 Apr;35(4):348-354. doi: 10.1080/09593985.2018.1443358. Epub 2018 Feb 26.

Reference Type BACKGROUND
PMID: 29482409 (View on PubMed)

Kim JM, Kim MW, Ko YJ. Correlating ultrasound findings of carpal tunnel syndrome with nerve conduction studies. Muscle Nerve. 2013 Dec;48(6):905-10. doi: 10.1002/mus.23841. Epub 2013 Sep 11.

Reference Type BACKGROUND
PMID: 23512486 (View on PubMed)

Aboonq MS. Pathophysiology of carpal tunnel syndrome. Neurosciences (Riyadh). 2015 Jan;20(1):4-9.

Reference Type BACKGROUND
PMID: 25630774 (View on PubMed)

Yucel H. Factors affecting symptoms and functionality of patients with carpal tunnel syndrome: a retrospective study. J Phys Ther Sci. 2015 Apr;27(4):1097-101. doi: 10.1589/jpts.27.1097. Epub 2015 Apr 30.

Reference Type BACKGROUND
PMID: 25995565 (View on PubMed)

Other Identifiers

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Sultan Abdulhamid Han

Identifier Type: -

Identifier Source: org_study_id

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