Correlation of Different Ultrasonographic Indices With Clinical Parameters in Carpal Tunnel Syndrome

NCT ID: NCT06115187

Last Updated: 2025-09-12

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 46 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-10-10
• Study Completion Date: 2025-03-01

Brief Summary

The aim of this study is to investigate the relationship between different ultrasonographic indices used in patients with carpal tunnel syndrome and clinical parameters.

The main questions it aims to answer are:

• To what extent are the ultrasonographic parameters used in the diagnosis of carpal tunnel syndrome related to the patient's clinical complaints?
• To what extent are the different ultrasonographic parameters used in the diagnosis of carpal tunnel syndrome correlated with each other?

Detailed Description

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy and the main mechanism is compression of the median nerve under the transverse ligament at the wrist level. In CTS, neuropathic complaints such as numbness, burning and tingling in the palmar face of the first two fingers, which are the innervation area of the median nerve, and fatigue in the hand are the most common symptoms. In the diagnosis of CTS, the diagnosis is made electrodiagnostically along with typical clinical findings. However, in recent years, ultrasound has become one of the most preferred methods in the diagnosis of CTS because it is non-invasive, rapid and correlates with electrodiagnostic methods. Diameter, cross-sectional area and echogenicity of the median nerve at the carpal tunnel entrance are the most frequently evaluated parameters in ultrasonographic examination. In different studies, it is aimed to increase the power of ultrasonography in the diagnosis of CTS with various indices created in addition to standardized measurements. The most commonly used ultrasonographic indices, which have been shown to be correlated with electrodiagnostic diagnostic methods, are the wrist-forearm median nerve cross-sectional area ratio, the ratio of median nerve cross-sectional area to carpal tunnel area at the carpal tunnel entry level, and echogenicity assessment. Although the relationship of these indexes, which are reported to have sufficient diagnostic sensitivity and specificity, with the patient's clinical complaints is shown on a measurement basis, there is not enough data on the comparison of different formulas and their correlation with the patient's clinical complaints, including neuropathic pain.Based on this, this study aimed to investigate the relationship between ultrasonographic indices used in patients diagnosed with CTS and clinical parameters.

Conditions

Carpal Tunnel Syndrome

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Patient group

Patients with carpal tunnel syndrome

Nerve ultrasound

Intervention Type: DIAGNOSTIC_TEST

Ultrasonographic evaluation of the median nerve at the carpal tunnel and adjacent levels

Nerve conduction studies

Intervention Type: DIAGNOSTIC_TEST

Upper extremity nerve conduction studies including median-ulnar sensory and motor responses

Interventions

Nerve ultrasound

Ultrasonographic evaluation of the median nerve at the carpal tunnel and adjacent levels

Intervention Type: DIAGNOSTIC_TEST

Nerve conduction studies

Upper extremity nerve conduction studies including median-ulnar sensory and motor responses

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Being diagnosed with carpal tunnel syndrome based on clinical and electrodiagnostic findings
• Agreeing to participate in the study

Exclusion Criteria

• Concomitant history of diabetes, systemic inflammatory disease, active infection and malignancy
• Having a disease with neuropathic pain such as polyneuropathy, radiculopathy,multiple sclerosis
• Not agreeing to participate in the study
• History of surgery due to CTS

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

OTHER

Sponsor Role: lead

Responsible Party

Feyza Nur Yucel

Specialist

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Emre Ata, Assoc.Prof

Role: STUDY_CHAIR

Saglik Bilimleri Universitesi

Locations

Saglik Bilimleri Universitesi

Istanbul, Uskudar, Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

23-516

Identifier Type: -

Identifier Source: org_study_id