CIRCAdian Rhythm of the IMMune Age IndeX (IMMAX)

NCT ID: NCT07169721

Last Updated: 2025-09-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-01

Study Completion Date

2024-04-22

Brief Summary

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The goal of this observational study is to evaluate the influence of circadian rhythms on the determination of an individual's immune age. The biomarker IMMAX was calculated for 50 participants aged 20-69 at 8 a.m., 1 p.m. and 6 p.m. on the same day.

Detailed Description

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Conditions

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Healthy Subjects Immune Cells (Mucosal and Systemic)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* aged \> 18 years
* knowledge of German or English sufficient to provide verbal explanations and obtain written consent

Exclusion Criteria

* exercise on the assessment day
* acute infection
* vaccination within the last 4 weeks
* autoimmune disease
* cancer
* drugs that may influence immune cell counts
* participation in other interventional studies during study period
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Leibniz Research Centre for Working Environment and Human Factors

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Leibniz Research Centre for Working and Environment and Human Factors

Dortmund, , Germany

Site Status

Countries

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Germany

References

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Brode P, Claus M, Gajewski PD, Getzmann S, Wascher E, Watzl C. From Immunosenescence to Aging Types-Establishing Reference Intervals for Immune Age Biomarkers by Centile Estimation. Int J Mol Sci. 2023 Aug 24;24(17):13186. doi: 10.3390/ijms241713186.

Reference Type BACKGROUND
PMID: 37685992 (View on PubMed)

Brode P, Claus M, Gajewski PD, Getzmann S, Golka K, Hengstler JG, Wascher E, Watzl C. Calibrating a Comprehensive Immune Age Metric to Analyze the Cross Sectional Age-Related Decline in Cardiorespiratory Fitness. Biology (Basel). 2022 Oct 27;11(11):1576. doi: 10.3390/biology11111576.

Reference Type BACKGROUND
PMID: 36358277 (View on PubMed)

Other Identifiers

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Ethics committee approval: 243

Identifier Type: -

Identifier Source: org_study_id

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