Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
131 participants
INTERVENTIONAL
2028-08-31
2031-05-31
Brief Summary
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* help make scans and exams faster
* reduce artifacts
* make MRI easier to understand
* allow technicians to focus more on the participant and less on the scanner
Participants will complete one brain MRI imaging session, lasting about 60 minutes.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Healthy Participants - Scan Efficiency
Participants not otherwise undergoing a brain MRI
Brain MRI - SOC and spiral
6 participants will be scanned using 2 versions (SOC and spiral) pf 6 sequences (12 scans total).
Standard of Care (SOC) Brain MRI
Participants undergoing SOC MRI
Brain MRI
90 participants will undergo a 60 minute SOC brain MRI followed by 15 minute spiral MRI
Healthy Participants - Tau
Participants not otherwise undergoing a brain MRI
Brain MRI - spiral
10 participants will be scanned with 3 sequences, 3 times (9 total scans per participants)
Healthy Participants - image quality
Participants not otherwise undergoing a brain MRI
Brain MRI - SOC and spiral
10 participants will be scanned using 2 versions (SOC and spiral) of 6 sequences (12 scans total).
Healthy Participants - SNR
Participants not otherwise undergoing a brain MRI
Brain MRI - spiral
10 participants will be scanned with 3 spiral sequences to achieve desired signal to noise ratio (SNR).
Healthy Participants - Gradient Derating
Participants not otherwise undergoing a brain MRI
Brain MRI - spiral
5 participants will be scanned with 2 pairs of 6 spiral sequences.
Interventions
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Brain MRI
90 participants will undergo a 60 minute SOC brain MRI followed by 15 minute spiral MRI
Brain MRI - SOC and spiral
6 participants will be scanned using 2 versions (SOC and spiral) pf 6 sequences (12 scans total).
Brain MRI - spiral
10 participants will be scanned with 3 sequences, 3 times (9 total scans per participants)
Brain MRI - SOC and spiral
10 participants will be scanned using 2 versions (SOC and spiral) of 6 sequences (12 scans total).
Brain MRI - spiral
10 participants will be scanned with 3 spiral sequences to achieve desired signal to noise ratio (SNR).
Brain MRI - spiral
5 participants will be scanned with 2 pairs of 6 spiral sequences.
Eligibility Criteria
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Inclusion Criteria
* Able to provide written informed consent on their own behalf
* Adults at least 18 years
* Able to provide written informed consent on their own behalf
* Scheduled for standard of care brain MRI
Exclusion Criteria
* Contraindication(s) to or inability to undergo MRI
* Currently pregnant
* Participants requiring intravenous (IV) conscious sedation for imaging are not eligible; participants requiring mild, oral anxiolytics for the clinical MRI will be allowed as long as the following criteria are met:
* participant has their own prescription for the medication
* informed consent process is conducted prior to the self-administration of the medication
* they come to the research visit with a driver
18 Years
ALL
Yes
Sponsors
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National Institute for Biomedical Imaging and Bioengineering (NIBIB)
NIH
University of Wisconsin, Madison
OTHER
Responsible Party
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Principal Investigators
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James Pipe, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Wisconsin, Madison
Locations
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University of Wisconsin - Madison
Madison, Wisconsin, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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A539300
Identifier Type: OTHER
Identifier Source: secondary_id
SMPH/RADIOLOGY/RADIOLOGY
Identifier Type: OTHER
Identifier Source: secondary_id
Protocol Version 6/2/2025
Identifier Type: OTHER
Identifier Source: secondary_id
2025-0948
Identifier Type: -
Identifier Source: org_study_id
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