Effects of Resistance and Aerobic Exercises on Walking and Sarcopenic Parameters in Parkinson's Disease
NCT ID: NCT07165106
Last Updated: 2025-09-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
30 participants
INTERVENTIONAL
2025-09-10
2026-01-01
Brief Summary
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Detailed Description
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This is a prospective, randomized, controlled trial. Assessments will be performed at baseline (week 0), at the end of treatment (week 6), and at follow-up (week 12). Outcome measures will include:
Handgrip strength Timed Up and Go Test (TUG) 4-meter gait speed test Short Physical Performance Battery (SPPB) Five-Times Sit-to-Stand Test (5CST) MDS-UPDRS Part II questionnaire
In addition, at baseline, ultrasonographic measurement of anterior thigh muscle thickness will be performed. This value, expressed in millimeters, will be divided by the body mass index (BMI) to calculate the STAR (Sonographic Thigh Adjustment Ratio) index.Participants will be randomized into three treatment groups:
Group 3 (Conventional Rehabilitation Program):
Patients will receive a standard physical therapy program, 5 days per week, for 1 hour per session. The protocol will include range of motion exercises for upper and lower extremities, stretching, walking, balance and coordination training, proprioceptive exercises, postural exercises, obstacle negotiation training, and turning-in-place exercises.
Group 2 (Conventional Rehabilitation + Resistance Training):
In addition to the conventional program, patients will perform resistance exercises for major muscle groups of the upper and lower extremities using elastic resistance bands, 3 days per week.
Group 1 (Conventional Rehabilitation + Treadmill Training):
In addition to the conventional program, patients will undergo treadmill exercise consisting of a 5-minute warm-up, 15 minutes of main exercise, and 5 minutes of cool-down. Walking speed will be individually adjusted according to participant tolerance, and exercise intensity will be monitored using the Borg Rating of Perceived Exertion (RPE) scale. Treadmill speed will be progressively increased in subsequent sessions under controlled conditions.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Conventional rehabilitation + Aerobic exercise
Participants will receive a standard conventional rehabilitation program combined with supervised aerobic exercise training (e.g., treadmill ) according to guideline-based frequency, intensity, and duration.
Aerobic Exercise
Participants in this group will receive conventional rehabilitation in combination with supervised treadmill-based aerobic exercise three times per week for 6 weeks. Each exercise session will consist of a 5-minute warm-up, a 15-minute main exercise phase, and a 5-minute cool-down. Walking speed will be individualized based on participant tolerance and progressively increased under clinical supervision. Exercise intensity will be monitored using the modified Borg Rating of Perceived Exertion (scale 6-20).
Weeks 1-2: Main exercise at Borg 10-11 (light-moderate).
Weeks 3-4: Main exercise at Borg 11-12 (moderate).
Weeks 5-6: Main exercise at Borg 12-13 (moderate-high).
Cardiorespiratory responses will be monitored during all sessions, and treadmill speed will be gradually adjusted in accordance with improvements in exercise tolerance while maintaining safety.
Conventional Rehabilitation
Participants in this group will receive conventional rehabilitation only, 5 days per week, 1 hour per day, for 6 weeks. The program includes upper and lower limb range of motion exercises, stretching, walking practice, balance and coordination training, proprioceptive exercises, posture correction, obstacle crossing, and turning in place. All sessions are delivered under clinical supervision, with emphasis on correct posture, safety, and full range of motion
Conventional rehabilitation + Resistance exercises
Participants will receive a standard conventional rehabilitation program combined with supervised resistance exercise training targeting major muscle groups with free weights or elastic bands.
Resistance Exercise
Participants in this arm will receive conventional rehabilitation combined with supervised resistance training using elastic bands, 3 times per week for 6 weeks. Exercises target major upper- and lower-limb and hip muscles. Each exercise is performed for 3 sets of 10 repetitions with 60-90 seconds rest. Initial band tension is set at the highest tolerable level and progressively increased. The program includes shoulder press, biceps curl, triceps extension, seated leg extension, calf raise, and lateral band walk. All sessions are supervised, emphasizing correct posture, controlled full range of motion, and avoidance of compensatory movements. Patients are guided with verbal and visual cues when necessary.
Conventional Rehabilitation
Participants in this group will receive conventional rehabilitation only, 5 days per week, 1 hour per day, for 6 weeks. The program includes upper and lower limb range of motion exercises, stretching, walking practice, balance and coordination training, proprioceptive exercises, posture correction, obstacle crossing, and turning in place. All sessions are delivered under clinical supervision, with emphasis on correct posture, safety, and full range of motion
Conventional rehabilitation
Participants will receive only the standard conventional rehabilitation program without any additional aerobic or resistance exercise.
Conventional Rehabilitation
Participants in this group will receive conventional rehabilitation only, 5 days per week, 1 hour per day, for 6 weeks. The program includes upper and lower limb range of motion exercises, stretching, walking practice, balance and coordination training, proprioceptive exercises, posture correction, obstacle crossing, and turning in place. All sessions are delivered under clinical supervision, with emphasis on correct posture, safety, and full range of motion
Interventions
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Aerobic Exercise
Participants in this group will receive conventional rehabilitation in combination with supervised treadmill-based aerobic exercise three times per week for 6 weeks. Each exercise session will consist of a 5-minute warm-up, a 15-minute main exercise phase, and a 5-minute cool-down. Walking speed will be individualized based on participant tolerance and progressively increased under clinical supervision. Exercise intensity will be monitored using the modified Borg Rating of Perceived Exertion (scale 6-20).
Weeks 1-2: Main exercise at Borg 10-11 (light-moderate).
Weeks 3-4: Main exercise at Borg 11-12 (moderate).
Weeks 5-6: Main exercise at Borg 12-13 (moderate-high).
Cardiorespiratory responses will be monitored during all sessions, and treadmill speed will be gradually adjusted in accordance with improvements in exercise tolerance while maintaining safety.
Resistance Exercise
Participants in this arm will receive conventional rehabilitation combined with supervised resistance training using elastic bands, 3 times per week for 6 weeks. Exercises target major upper- and lower-limb and hip muscles. Each exercise is performed for 3 sets of 10 repetitions with 60-90 seconds rest. Initial band tension is set at the highest tolerable level and progressively increased. The program includes shoulder press, biceps curl, triceps extension, seated leg extension, calf raise, and lateral band walk. All sessions are supervised, emphasizing correct posture, controlled full range of motion, and avoidance of compensatory movements. Patients are guided with verbal and visual cues when necessary.
Conventional Rehabilitation
Participants in this group will receive conventional rehabilitation only, 5 days per week, 1 hour per day, for 6 weeks. The program includes upper and lower limb range of motion exercises, stretching, walking practice, balance and coordination training, proprioceptive exercises, posture correction, obstacle crossing, and turning in place. All sessions are delivered under clinical supervision, with emphasis on correct posture, safety, and full range of motion
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Diagnosis of sarcopenia according to the EWGSOP2 criteria.
* Hoehn \& Yahr stage 2-3.
* Ability and willingness to provide written informed consent according to the approved study consent form.
Exclusion Criteria
* Hoehn \& Yahr stage 1 or 4.
* History of malignancy.
* Epilepsy.
* History of cardiac pacemaker implantation.
* Presence of congestive heart failure.
* Orthopedic conditions affecting walking or balance.
* Respiratory disorders impairing exercise capacity.
* Uncontrolled hypertension.
* Inability to cooperate with study procedures.
* History of neuromuscular or vestibular disorders affecting gait or balance parameters.
* Lack of willingness to participate in the study.
40 Years
85 Years
ALL
No
Sponsors
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Ahi Evran University Education and Research Hospital
OTHER
Responsible Party
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Nedime Seven Tas
Principal Investigator
Locations
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Kırşehir Ahi Evran University
Kırşehir, , Turkey (Türkiye)
Countries
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Central Contacts
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Other Identifiers
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AhiEvranUERH-FTR-NST-01
Identifier Type: -
Identifier Source: org_study_id
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