Endometriosis-Angiopoietin-like Protein-4

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-05

Study Completion Date

2025-09-02

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Endometriosis is a chronic inflammatory disease associated with pelvic pain, dyspareunia, and impaired ovarian reserve. Cancer antigen-125 (CA-125) is widely studied but limited by low specificity, while angiopoietin-like protein-4 (ANGPTL4) has emerged as a potential biomarker due to its role in angiogenesis and inflammation. In the current study it was aimed to investigate serum and peritoneal fluid ANGPTL4 levels in women with endometriosis compared to healthy controls, and to evaluate their associations with clinical symptoms, serum CA-125, and anti-Müllerian hormone levels.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Evaluation of New Biomarkers in Stage 3 and 4 Endometriosis

NCT05312528

Endometriosis

COMPLETED

Endometriosis and Complement System

NCT06495151

Endometriosis Complement System Alternative Complement Pathway

COMPLETED

Serum Trace Element Levels in Some Gynecological Diseases

NCT07210918

Endometriosis Endometrial Cancer Over Cancer +1 more

COMPLETED NA

Serum and Peritoneal Fluid Bank for Endometriosis Markers

NCT00194233

Endometriosis

COMPLETED

Evaluation of Serum Ages Levels in Patients With Endometriosis

NCT04886024

Endometriosis

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Endometriosis Angiopoietin-like Protein-4 Pelvic Pain

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Endometriosis group (Study group)

The study group included women with endometriosis. The study group consisted of women diagnosed with endometriosis who consecutively underwent laparoscopic endometriosis surgery.

Angiopoietin-like protein-4 (ANGPTL4) Peritoneal Fluid Level

Intervention Type OTHER

Measurement of peritoneal fluid levels of Angiopoietin-like protein-4 (ANGPTL4) level by ELISA method.

Cancer Antigen 125 (CA-125) Serum Level

Intervention Type OTHER

Measurement of venous blood serum level of CA-125 level by ELISA method.

Angiopoietin-like protein-4 (ANGPTL4) Serum Level

Intervention Type OTHER

Measurement of venous blood serum level of Angiopoietin-like protein-4 (ANGPTL4) Level level by ELISA method.

Healthy women (Control group)

Control group consisted of healthy women. The control group consisted of women who consecutively visited the outpatient clinic for routine gynecologic examinations and had no known diseases.

Cancer Antigen 125 (CA-125) Serum Level

Intervention Type OTHER

Measurement of venous blood serum level of CA-125 level by ELISA method.

Angiopoietin-like protein-4 (ANGPTL4) Serum Level

Intervention Type OTHER

Measurement of venous blood serum level of Angiopoietin-like protein-4 (ANGPTL4) Level level by ELISA method.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Angiopoietin-like protein-4 (ANGPTL4) Peritoneal Fluid Level

Measurement of peritoneal fluid levels of Angiopoietin-like protein-4 (ANGPTL4) level by ELISA method.

Intervention Type OTHER

Cancer Antigen 125 (CA-125) Serum Level

Measurement of venous blood serum level of CA-125 level by ELISA method.

Intervention Type OTHER

Angiopoietin-like protein-4 (ANGPTL4) Serum Level

Measurement of venous blood serum level of Angiopoietin-like protein-4 (ANGPTL4) Level level by ELISA method.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Diagnosis of endometriosis for study group who underwent laparoscopic endometriosis surgery
* Healthy women for control group

Exclusion Criteria

* Cardiovascular diseases including hypertension
* Type 1 or type 2 diabetes mellitus
* Morbid obesity
* Primary adrenal insufficiency
* Uterine fibroids
* Thyroid dysfunctions including Hashimoto thyroiditis and Grave's disease
* Hepatic dysfunctions
* Renal insufficiency
* Genetic disorders in chromosome constitution or karyotype analysis including monosomy X, trisomy X and gene mutations as BMP15, FMR I, POFIB, and GDF9
* Neurologic diseases
* Psychiatric disorders
* Autoimmune diseases or syndromes including Addison's disease, autoimmune syndromes, scleroderma, Sjogren's syndrome, myasthenia gravis, inflammatory bowel diseases, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus and familial Mediterranean fever
* History of any malignancy
* History of exposure to chemotherapeutic agents or radiotherapy

Minimum Eligible Age

18 Years

Maximum Eligible Age

44 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes