Anti-inflammatory Markers in Endometrioma

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

48 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-08-15

Study Completion Date

2020-03-15

Brief Summary

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Investigators aimed to measure the serum levels of adropin, salusin-α, netrin-1, and nesfatin-1, anti-inflammatory effects of which have been demonstrated previously, in endometriosis patients and to find out any association of them with insulin resistance.

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Detailed Description

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Endometriosis is defined as the presence of endometrial gland and stroma outside the endometrial cavity affecting almost 10% of the women of reproductive age. Although benign, it disrupts the quality of life of the inflicted patients through symptoms such as dysmenorrhae, dyspareunia, chronic pelvic pain, and infertility. The pathogenesis of endometriosis has not yet been clearly elucidated, however, recent papers implies an underpinning role of inflammation There is a limited number of studies about the levels of these parameters in endometriosis and to date, no report is available on the levels of adropin and netrin-1 in endometriosis. Likewise, according to the investigator's literature search, no research explaining the association of endometriosis with insulin resistance has yet been published. In present study, in an attempt to describe inflammatory pathways playing a role in endometriosis pathogenesis, Investigators aimed to measure the levels of serum adropin, salusin-α, netrin-1, and nesfatin-1, anti-inflammatory effects of which have been priorly demonstrated, and to find out any association of them with insulin resistance.

Conditions

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Endometrioma Inflammation

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Endometrioma

Endometrioma (n=23)

Adropin (ng/L)

Intervention Type DIAGNOSTIC_TEST

Thawed samples were measured on a Molecular Devices SpectraMax i3 Multi-Mode, Microplate Reader (batch number: SER 35 370-1448, made in Austria) using enzyme linked immunosorbent assay (ELISA).

Healthy controls

Healthy controls Healthy volunteers n=25

Adropin (ng/L)

Intervention Type DIAGNOSTIC_TEST

Thawed samples were measured on a Molecular Devices SpectraMax i3 Multi-Mode, Microplate Reader (batch number: SER 35 370-1448, made in Austria) using enzyme linked immunosorbent assay (ELISA).

Interventions

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Adropin (ng/L)

Thawed samples were measured on a Molecular Devices SpectraMax i3 Multi-Mode, Microplate Reader (batch number: SER 35 370-1448, made in Austria) using enzyme linked immunosorbent assay (ELISA).

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Salusin-α (pg/mL) Netrin-1 (pg/mL) Nesfatin-1 (ng/mL)

Eligibility Criteria

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Inclusion Criteria

·Histopathologically confirmed diagnosis of endometrioma

Exclusion Criteria

* Any patients with DM,
* chronic kidney disease (CKD),
* CAD,
* heart failure (HF),
* cerebrovascular accident (CVA),
* malignancy,
* rheumatoid disorder,
* liver disease, and
* active infections were excluded from the study.

Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes