MIND Diet in Relation to Malnutrition and Depression in AD

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-15

Study Completion Date

2024-10-15

Brief Summary

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The aim of this study was to examine the association between depression, malnutrition, and the Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) diet in Alzheimer's disease patients. This study included 30 patients with Alzheimer's disease (AD) and 30 healthy controls. A questionnaire form including sociodemographic characteristics was applied to the individuals. In addition, anthropometric measurements, biochemical parameters, nutritional status (Food Frequency Questionnaire (FFQ), Mini Nutritional Assessment-Short Form (MNA-SF), Geriatric Nutritional Risk Index (GNRI) and MIND diet scores) and mental health status (Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI)).

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Detailed Description

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Significant progress has been made in understanding the neurobiological basis and treatment approaches for Alzheimer's disease (AD) and depression; however, the biological link between these two disorders has not yet been fully elucidated. A deeper understanding of this relationship could contribute to the development of more effective strategies for the prevention and treatment of both conditions. In this context, lifestyle-based interventions, such as nutrition, which have been shown to support cognitive health, emerge as a potential preventive and therapeutic approach. Therefore, the aim of this study was to examine the relationship between depression, malnutrition, and the Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) diet in individuals with AD.

Conditions

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Alzheimer Disease (AD) Healthy Controls Group - Age and Sex-matched

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Alzheimer's Disease Patients

Participants diagnosed with Alzheimer's disease according to established clinical criteria. Evaluated for malnutrition and depression status. No intervention was applied.

No interventions assigned to this group

Healthy Controls

Age- and sex-matched individuals without Alzheimer's disease. Evaluated for malnutrition and depression status. No intervention was applied.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients aged over 60 years.
* Diagnosed with Alzheimer's disease (AD) (for AD group)
* Able to communicate with themselves or their companions
* Healthy volunteers without systemic or neurological diseases (for control group)
* Matching criteria: Age, gender, smoking status, and alcohol use

Exclusion Criteria

* Chronic inflammatory diseases
* Schizophrenia
* Bipolar disorder
* Amputations
* Neoplastic disorders
* End-stage liver disease
* End-stage kidney disease

Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes