REACT - Resistance Exercise After Cancer Treatment

NCT ID: NCT07159815

Last Updated: 2025-09-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-08-01

Study Completion Date

2028-06-30

Brief Summary

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Resistance exercise has been shown to improve several important health variables after cancer and cancer related treatment, but unfortunately the adherence to resistance exercise is low. Typical reported exercise barriers are inconvenient location (e.g. long distance from home), exercise at an unfavorable time of the day, inadequate access to cancer-specific exercise and insufficient recommendations from healthcare providers. Thus, there is need for more research on resistance exercise with an alternative approach in cancer rehabilitation, that potentially can target a broad range of patients, despite their domicile. In Norway, the foundation "Active against cancer" has established exercise locations tareting cancer patients in several hospitals, and today they also offer digital home-based exercise sessions. Therefore, the overall research objectives are to compare the efficacy of 12 weeks digital, home-based resistance exercise program on cancer patients after treatment on functional, mental, and metabolic health, compared to the same program conducted in a studio under guidance of an instructor. The primary aim is to compare the effect on exercise adherence between digital home-based exercise program and on-site guided program on cancer patients after treatment. Secondary aims are to compare the two groups on several functional health outcomes, mental health outcomes and metabolic health markers.

Detailed Description

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Conditions

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Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The project is an assessor-blinded randomized controlled trial, where included participants will be randomized to either 12 weeks of digital home-based resistance exercise or the same program conducted in a studio under guidance of an instructor.
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors
Assessment of all the outcomes will be performed in a blinded fashion by assessors/investigators.

Study Groups

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Digital home-based resistance exercise

Participants in the digital group will need an e-mail and access to a pc and/or ipad at home. They will get access to a closed group on a digital platform, for participants in the project only. They will be asked to perform two pre-recorded resistance exercise sessions each week, for 12 weeks. Each session last for 40 minutes, and include 10 minutes of warm-up (ldynamic mobility and low impact), 25 minutes of resistance exercises (8-15 repetitions x 2-4 sets), and 5 minutes of cool-down and stretching. A total of 24 exercises will be performed over the period of 12 weeks.

Group Type EXPERIMENTAL

Digital follow-up

Intervention Type OTHER

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Resistance exercise

Intervention Type BEHAVIORAL

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On-site resistance exercise

Participants in the on-site group will be asked to participate in resistance exercise on-site with instructor, two times a week for 12 weeks. They will follow the exact same exercise program as the digital group. Participants living around the Gjøvik area will have their exercise sessions at The Inland hospital Gjøvik (with physiotherapist and instructor supervising/mentoring the students), and for participants living around Lillehammer the exercise will be held at a medical clinic (with physiotherapist and instructor supervising/mentoring the students). A total of 24 exercises will be performed over the period of 12 weeks.

Group Type EXPERIMENTAL

On-site follow-up

Intervention Type OTHER

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Resistance exercise

Intervention Type BEHAVIORAL

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Interventions

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Digital follow-up

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Intervention Type OTHER

On-site follow-up

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Intervention Type OTHER

Resistance exercise

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Intervention Type BEHAVIORAL

Other Intervention Names

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Cancer rehabilitation, digital follow-up On-site cancer rehabilitation, on-site follow-up Cancer rehabilitation

Eligibility Criteria

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Inclusion Criteria

* ≥ 18 years and able to give informed consent
* Previously diagnosed with any form of cancer and completed systemic chemotherapy, immunotherapy or targeted therapies or local radiotherapy
* Have completed active cancer treatment not more than 12 months earlier or at present undergoing oral home-based treatment for stabilization or other treatments of disease or to prevent relapse
* Life expectancy of more than 12 months
* Digital opportunities at home: e.g axcess to pc, and/or ipad, email adress to log on the platform
* Able to understand Norwegian language

Exclusion Criteria

* Co-morbidities prohibiting exercise according to protocol like serious cardic, pulmonary and other organ diseases
* Conditions caused by the cancer which prohibits exercise like previous major surgery, fractures, pain
* Still undergoing active cancer treatment that is expected to confer a high risk of bone marrow suppresion that would lead to infections, bleeding and/or severly reduced physical capacity
* Life expectancy of less than 12 months
* Reduced mental capacity and not able to give informed consent and follow the program
* Travelling distance more than 20 km from home or workplace to the two exercise locations (Gjøvik and/or Lillehammer) for patients who are candidates for randomization
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sykehuset Innlandet HF

OTHER

Sponsor Role collaborator

Inland Norway University of Applied Sciences

OTHER

Sponsor Role lead

Responsible Party

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Stian Ellefsen

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Inland Norway University of Applied Sciences

Lillehammer, , Norway

Site Status RECRUITING

Countries

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Norway

Central Contacts

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Anne Mette Rustaden, PhD

Role: CONTACT

+47 48100644

Stian Ellefsen, Professor

Role: CONTACT

Facility Contacts

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Anne Mette Rustaden, PhD

Role: primary

Stian Ellefsen, Professor

Role: backup

Other Identifiers

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TR033

Identifier Type: -

Identifier Source: org_study_id

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