The Effect of Resistance Training and Aerobic Training on Body Composition During Chemotherapy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-02-28

Study Completion Date

2016-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Chemotherapy can induce muscle loss in colorectal, breast and advanced renal cell carcinoma patients. The Danish nation-wide training and rehabilitation offer 'Body \& Cancer' offers intensive resistance and endurance training to all Danish cancer patients receiving chemotherapy with the aim of reducing treatment-related fatigue and physical impairments, but the potential of the training to preserve or improve muscle mass is uninvestigated.

Furthermore, the underlying biological mechanisms of treatment and/or exercise induced changes in muscle mass in cancer patients remains uninvestigated.

Thus, the primary purpose of the present study is to investigate changes in body composition during chemotherapy and after resistance and aerobic training combined with protein supplementation during ongoing chemotherapy in cancer patients. Secondly, we aim to investigate the underlying biological mechanisms of muscle mass regulation in biopsies obtained before and after a control period as well as after 10 weeks of exercise, both during chemotherapy.

We hypothesize that 10 weeks exercise will improve muscle mass and body composition in cancer patients during chemotherapy as compared to a control period during chemotherapy alone.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effect of Heavy-load Resistance Training During Chemotherapy on Muscle Cellular Outcomes

NCT04586517

Breast Cancer Female

UNKNOWN NA

Effects of Moderate and High-intensity Exercise During Chemotherapy on Muscle Cells in Women With Breast Cancer

NCT05218876

Breast Cancer Female

COMPLETED NA

Physical Training and Cancer-a Multicenter Clinical Trial

NCT02473003

Breast Cancer Colorectal Cancer Prostate Cancer

ACTIVE_NOT_RECRUITING NA

Effects of Aerobic Exercise Versus Weight Training in Breast Cancer Survivors During Chemotherapy

NCT00115713

Breast Neoplasms

COMPLETED PHASE3

Progressive Resistance Training Program in Head and Neck Cancer Patients

NCT02068950

Head and Neck Cancer

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Neoplasms

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Exercise & Chemotherapy

Following a control period during active chemotherapy the patients undergo ten weeks of supervised exercise comprised of resistance and aerobic training in combination with protein supplementation during ongoing chemotherapy.

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Exercise

Intervention Type BEHAVIORAL

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Resistance training Aerobic exercise Protein supplementation

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Currently receiving curative, adjuvant, neo-adjuvant or palliative chemotherapy
* No documented bone metastases or myelomatosis
* No documented CNS affection
* WHO performance status 0-1
* No chronical thrombocytopenia or leukopenia
* No physical conditions preventing exercise participation
* No serious symptoms of heart disease
* No dementia or mental illness preventing participation
* Signed written concent
* Age above 18 years