Acute Immunological Effects of Exercise in Cancer Patients

NCT ID: NCT05656651

Last Updated: 2024-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE2

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-12-19

Study Completion Date

2025-07-31

Brief Summary

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The aim of the study is to evaluate and compare immune response to a single exercise intervention in cancer patients and healthy age-maged individuals.

Detailed Description

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Conditions

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Cancer

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Cancer patients

Single exercise intervention following a HIIT protocol, duration \~20 mins

Group Type EXPERIMENTAL

High intensity interval exercise training

Intervention Type BEHAVIORAL

Endurance training adapted to age, resting heart rate

Healthy adults

Single exercise intervention following a HIIT protocol, duration \~20 mins

Group Type ACTIVE_COMPARATOR

High intensity interval exercise training

Intervention Type BEHAVIORAL

Endurance training adapted to age, resting heart rate

Interventions

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High intensity interval exercise training

Endurance training adapted to age, resting heart rate

Intervention Type BEHAVIORAL

Other Intervention Names

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HIIT, Exercise

Eligibility Criteria

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Inclusion Criteria

* Adolescents and young adults \>14 years of age
* undergoing acute cancer treatment (chemotherapy)
* signed informed consent

Exclusion Criteria

* Inability to follow and implement test instructions
* medical contraindication to HIIT on cycle ergometer
* chemotherapeutic treatment 48 h prior
* Hb \<8g/dl; platelets \< 20,000/ul.
Minimum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Universität Duisburg-Essen

OTHER

Sponsor Role lead

Responsible Party

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Miriam Götte

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Miriam Götte, Dr.

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Essen

Locations

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University Hospital Essen

Essen, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

References

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Deppe I, Beller R, Kiehl F, Lazzari N, Bennstein SB, Reinhardt D, Dirksen U, Gotte M. The impact of a single HIIT intervention on the mobilization of NK cells and ILCs in adolescents and young adults (AYA) undergoing cancer treatment: an interventional controlled trial. BMC Cancer. 2025 Apr 14;25(1):689. doi: 10.1186/s12885-025-14058-3.

Reference Type DERIVED
PMID: 40229731 (View on PubMed)

Other Identifiers

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ACTIVE

Identifier Type: -

Identifier Source: org_study_id