Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
34 participants
INTERVENTIONAL
2025-07-16
2026-09-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Genicular Nerve Block
This arm of patients (17 total) will receive the genicular nerve block for their knee pain.
Genicular nerve block with bupivacaine and corticosteroids
genicular nerve block with ideal body-weight dosing of bupivacaine 0.5% with 4 mg dexamethasone
Standard of Care
This arm of patients (17 total) will receive standard of care analgesia for their knee pain
Standard of Care
This involves standard of care pain relief for patients who do not receive the genicular nerve block for knee pain, such as acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), and opioids.
Interventions
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Genicular nerve block with bupivacaine and corticosteroids
genicular nerve block with ideal body-weight dosing of bupivacaine 0.5% with 4 mg dexamethasone
Standard of Care
This involves standard of care pain relief for patients who do not receive the genicular nerve block for knee pain, such as acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), and opioids.
Eligibility Criteria
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Inclusion Criteria
* \>17 years age
* X-ray of the knee obtained in the ED
* Initial pain score (numeric rating scale) 5-10
Exclusion Criteria
* large knee joint effusion identified on x-ray
* allergy or contraindication to local anesthetics
* History of local anesthetic systemic toxicity after receiving local anesthetics
* Pregnancy
* Incarcerated
* History of knee replacement of affected knee
* Concern for septic joint
* Overlying cellulitis
* Hemodynamic instability
* Altered mental status or inability to consent for procedure.
18 Years
ALL
No
Sponsors
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University of Pennsylvania
OTHER
Responsible Party
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Principal Investigators
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Michael M Shalaby, MD
Role: PRINCIPAL_INVESTIGATOR
University of Pennsylvania
Locations
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Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Pennsylvania Hospital
Philadelphia, Pennsylvania, United States
Pennsylvania Presbyterian Medical Center
Philadelphia, Pennsylvania, United States
HUP Cedar
Philadelphia, Pennsylvania, United States
Countries
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Central Contacts
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Facility Contacts
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Provided Documents
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Document Type: Study Protocol
Document Type: Informed Consent Form
Other Identifiers
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IRB Protocol #858259
Identifier Type: -
Identifier Source: org_study_id
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