Artificial Intelligence in Trapeziometacarpal Joint Osteoarthritis: Improving Assessment and Clinical Decision-Making
NCT ID: NCT07148349
Last Updated: 2025-09-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
2500 participants
OBSERVATIONAL
2025-09-30
2028-08-31
Brief Summary
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The project is divided into four subprojects: (1) development of a new radiographic classification system for TMC OA, (2) automation of the classification using deep learning, (3) automated detection of implant migration, and (4) 3-dimensional (3D) reconstruction of the TMC joint from biplanar radiographs.
Data will be sourced from two cohorts: patients from our clinical TMC arthroplasty registry who received the Touch implant, and patients with other wrist-related conditions who underwent radiographic imaging with a visible TMC joint. Together, these cohorts provide a broad coverage across the full spectrum of OA severity.
OA-related features and implant related features will serve as the foundation for model training and validation. Also, they will be validated with CT images regarding reliability and accuracy. The resulting prototypes for automated OA staging, implant migration detection, and 3D modeling of the TMC joint are exclusively used for research purposes. Any future clinical use of these tools, including evaluation under Swissmedic (Swiss Agency for Therapeutic Products) regulations, will be part of a separate project.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Osteoarthritis
Patients in our TMC arthroplasty registry (Business Administration System for Ethics Committees (BASEC) number: 2019-02096): Patients who received a Touch implant for TMC joint arthroplasty. Data will be included in the study from the creation of the registry in 2018 until the end of January 2028.
No Intervention: Observational Cohort
No Intervention: Observational Cohort
Healthy
Patients with other clinical conditions leading to TMC joint radiography.
No Intervention: Observational Cohort
No Intervention: Observational Cohort
Interventions
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No Intervention: Observational Cohort
No Intervention: Observational Cohort
Eligibility Criteria
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Inclusion Criteria
TMC OA group:
• Patients who received a Touch implant for TMC joint arthroplasty and are documented in our clinical registry
Other clinical conditions:
• Patients who underwent radiographic imaging for one of the following conditions, with a clearly visible TMC joint, for example: Distal radius fracture, carpal fracture, finger dislocation, or similar.
Exclusion Criteria
* Patients with posttraumatic OA.
* Patients with rheumatoid arthritis.
Other clinical conditions:
* Eaton Littler score higher than one.
* Prior surgery affecting the trapezium or the first metacarpal.
* Clinical condition resulting in abnormal TMC joint morphology.
Furthermore, patients will also be excluded if they revoke their consent in writing or via verbal withdrawal.
ALL
Yes
Sponsors
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ETH Zurich (Switzerland)
OTHER
Schulthess Klinik
OTHER
Responsible Party
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Locations
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Schulthess Klinik
Zurich, Canton of Zurich, Switzerland
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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OE-0259
Identifier Type: -
Identifier Source: org_study_id
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