Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis

NCT ID: NCT07301892

Last Updated: 2025-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-10-01

Study Completion Date

2026-06-30

Brief Summary

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Generative AI (GenAI) based on large language models (LLMs) is expected to improve the diagnosis and treatment of autoimmune diseases. We are studying how GenAI may affect the diagnosis of various complications of rheumatoid arthritis (RA). In a retrospective study using RA patients' EHR records, we will quantify physician adoption of GenAI predictions for RA complications and co-existing diseases. In a prospective observational study, we will assess the feasibility of using GenAI predictions as additional clinical information to help physicians make more complete diagnoses of RA complications and co-existing diseases, including complex, uncommon, or rare conditions.

Detailed Description

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Conditions

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Rheumatoid Arthritis (RA Osteoporosis Osteoarthritis Interstitial Lung Disease Thyroid Diseases Cardiovascular Diseases Pulmonary Complications Sjogren's Syndrome Liver Disorders Renal Lesions Vasculitis Amyloidosis Peripheral Neuropathy Thrombosis RA Complications

Keywords

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Rheumatoid Arthritis generative AI large language model Rheumatoid arthritis complications

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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RA patient group using generative AI prediction reports

Inpatients newly diagnosed with rheumatoid arthritis in our rheumatology department between October 1, 2025, and June 2026 will be recruited for the study. Physicians will use GenAI predictions of potential RA complications and co-existing diseases, together with confirmatory diagnostic tests, as additional inputs in the differential diagnosis process.

Generative AI prediction report for RA complications

Intervention Type OTHER

Generative AI based on multiple large language models (LLMs) is used to predict potential complications and co-existing diseases in patients with rheumatoid arthritis using EHR data available at admission. Physicians use these AI predictions as additional information to adjust their diagnostic plans during differential diagnosis. The impact of this intervention on the final diagnoses at discharge will be measured.

Before the prospective study, the adoptability of the generative AI prediction reports will be validated using EHR records from retrospective RA patients.

Interventions

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Generative AI prediction report for RA complications

Generative AI based on multiple large language models (LLMs) is used to predict potential complications and co-existing diseases in patients with rheumatoid arthritis using EHR data available at admission. Physicians use these AI predictions as additional information to adjust their diagnostic plans during differential diagnosis. The impact of this intervention on the final diagnoses at discharge will be measured.

Before the prospective study, the adoptability of the generative AI prediction reports will be validated using EHR records from retrospective RA patients.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with an initial diagnosis of rheumatoid arthritis (RA).
* All real-world RA inpatients admitted to our department.
* Admission occurring within the real-world data study period.

Exclusion Criteria

* Patients subsequently confirmed not to have RA during the study.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Guang'anmen Hospital of China Academy of Chinese Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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Quan Jiang

Director of the Rheumatology Department

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Guang'anmen Hospital of China Academy of Chinese Medical Sciences

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Quan Jiang Guang'anmen Hospital, China Academy of Chinese Medical Science

Role: CONTACT

Phone: 010-88001942

Email: [email protected]

Facility Contacts

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Quan Jiang, MD

Role: primary

Related Links

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https://pubmed.ncbi.nlm.nih.gov/38109889/

Our previous study benchmarking LLMs for predicting a range of diseases.

https://www.nature.com/articles/s41584-025-01310-0

A recent paper reviewing LLMs in clinical decision support for autoimmune diseases.

Other Identifiers

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2025-201-KY

Identifier Type: -

Identifier Source: org_study_id