Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines
NCT ID: NCT07142369
Last Updated: 2025-12-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
99 participants
INTERVENTIONAL
2026-01-31
2028-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Two Synovial Fluid Withdrawals
Subjects randomized to Arm 1 will have 2 synovial fluid withdrawals; one at the preoperative clinic visit and one at the time of surgery
Synovial Fluid withdrawal at the preoperative clinic visit
Synovial Fluid withdrawal at the preoperative clinic visit
Synovial fluid withdrawal at the time of surgery
Synovial fluid withdrawal at the time of surgery
Platelet-Rich Plasma (PRP) and Two Synovial Fluid Withdrawals
Subjects randomized to ARM 2 will have 2 synovial fluid withdrawals one at the preoperative visit and one at the time of surgery. Platelet-Rich Plasma (PRP) preparation and injection will happen at the preoperative clinic visit.
Synovial Fluid withdrawal at the preoperative clinic visit
Synovial Fluid withdrawal at the preoperative clinic visit
Platelet-Rich Plasma (PRP) preparation and injection
Platelet-Rich Plasma (PRP) preparation and injection
Synovial fluid withdrawal at the time of surgery
Synovial fluid withdrawal at the time of surgery
3mL Synovial Fluid Withdrawal and Synovial Fluid Withdrawal at the Time of Surgery
Subjects randomized to Arm 3 will have 3mL withdrawal of synovial fluid at the preoperative visit and 1 synovial fluid withdrawal at the time of surgery
Synovial fluid withdrawal at the time of surgery
Synovial fluid withdrawal at the time of surgery
3mL synovial fluid withdrawn at the preoperative visit
3mL synovial fluid withdrawn at the preoperative visit
Interventions
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Synovial Fluid withdrawal at the preoperative clinic visit
Synovial Fluid withdrawal at the preoperative clinic visit
Platelet-Rich Plasma (PRP) preparation and injection
Platelet-Rich Plasma (PRP) preparation and injection
Synovial fluid withdrawal at the time of surgery
Synovial fluid withdrawal at the time of surgery
3mL synovial fluid withdrawn at the preoperative visit
3mL synovial fluid withdrawn at the preoperative visit
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* English-speaking
* Clinical evidence of ACL rupture with swelling
* Participant must be undergoing ACL reconstruction surgery
Exclusion Criteria
* Presentation \>3 weeks after initial injury
* Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery
* \> Kellgren-Lawrence grade 2 changes on preoperative x-ray
* History of hemophilia or inflammatory arthropathy (e.g., rheumatoid arthritis)
18 Years
50 Years
ALL
No
Sponsors
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Arthroscopy Association of North America (AANA)
UNKNOWN
Rush University Medical Center
OTHER
Responsible Party
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Principal Investigators
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Adam Yanke, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Associate Professor and Surgeon
Locations
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Rush University Medical Center
Chicago, Illinois, United States
Countries
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Central Contacts
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Other Identifiers
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24120505
Identifier Type: -
Identifier Source: org_study_id
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