Clinical Outcome of Intra Articular Injection of Autologous Platelet Rich Plasma in Anterior Cruciate Ligament Injury.
NCT ID: NCT07185802
Last Updated: 2025-09-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
NA
52 participants
INTERVENTIONAL
2025-08-27
2026-08-26
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
In this study, participants will be randomly assigned to one of two groups. The experimental group will receive a single ultrasound-guided injection of PRP into the knee joint along with a standard rehabilitation program. The control group will receive the rehabilitation program alone.
Participants will be followed up at 3 weeks, 8 weeks, and 16 weeks after treatment. At each follow-up visit, knee function, pain level, and physical performance will be assessed using validated outcome measures. The primary aim is to determine whether PRP provides additional benefit compared with rehabilitation alone in improving function and reducing symptoms in ACL-injured patients.
This study will provide new evidence about the role of PRP in ACL management, which may help guide future treatment decisions.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Effectiveness of Autologous Platelet-rich Plasma on Knee Cartilage Injury
NCT03024801
The Effect of Platelet Rich Plasma (PRP) on Post Operative Pain in Anterior Cruciate Ligament Reconstruction
NCT01765712
PRP in ACLR to Prevent PTOA
NCT05412381
Can PRP Reduce Pro-Inflammatory Biomarkers Following ACL Injury
NCT03389685
Effects of Platelet Rich Plasma Injections on Biomarkers After Anterior Cruciate Ligament Tears
NCT04088227
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Group A/Experimental group
Will receive PRP and conventional conservative method (physical therapy, functional bracing, lifestyle modification)
PRP injection
Ultrasound guided intraarticular PRP is given to the patient with partial ACL tear
conventional conservative method (physical therapy, functional bracing, lifestyle modification)
conventional conservative method (physical therapy, functional bracing, lifestyle modification)
Group B/Control group
Will receive conventional conservative method (physical therapy, functional bracing, lifestyle modification) only
conventional conservative method (physical therapy, functional bracing, lifestyle modification)
conventional conservative method (physical therapy, functional bracing, lifestyle modification)
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
PRP injection
Ultrasound guided intraarticular PRP is given to the patient with partial ACL tear
conventional conservative method (physical therapy, functional bracing, lifestyle modification)
conventional conservative method (physical therapy, functional bracing, lifestyle modification)
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* 3 or Less than 3-months history of knee injuries
* ACL injury MRI Grade 1 (Low) and medium Grade 2 (Medium) grade
* ACL injury associated with Grade 1 or 2 Posterior cruciate ligament (PCL) tear and/or Grade 1 or 2 meniscal tear
* The Complete Blood Count (CBC) report shows a hemoglobin \> 10gm/dl and platelet count \>150,000/microliter prior to the procedure
* Capable of comprehending informed consent
Exclusion Criteria
* Patients who are taking systemic steroid
* Patients who are younger than 18 and older than 50 years
* Those with a history of platelet disorders or on the therapeutic anticoagulant or anti platelet drugs
* Hemoglobin below 10 gm/dl
* Platelet count \<150000/microliter
* Complete tear of both bundles on MRI
* Grade 3 or more PCL and meniscal tear on MRI
* Previous or concurrent ligament reconstruction in the index knee joint.
* Connective tissue disorders like Marfan Syndrome, Ehler-Danlos Syndrome etc.
* Any inflammatory disease like Rheumatoid Arthritis, spondyloarthritis, gout, pseudogout etc involving the knee joint.
18 Years
50 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Isfath Fauzia
Resident
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Dr. Isfath Fauzia, MBBS
Role: PRINCIPAL_INVESTIGATOR
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Prof. Dr. Md. Ali Emran, MBBS, FCPS
Role: STUDY_CHAIR
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Dr. Md. Nuruzzaman Khandaker, MBBS, FCPS
Role: STUDY_DIRECTOR
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Dr. Md. Tariqul Islam, MBBS, FCPS
Role: STUDY_DIRECTOR
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Bangabandhu Sheikh Mujib Medical University
Dhaka, , Bangladesh
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
5744
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.