Motor Imagery and Action Observation for Gait Function in MS
NCT ID: NCT07137624
Last Updated: 2025-09-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
20 participants
INTERVENTIONAL
2025-09-15
2025-10-31
Brief Summary
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Detailed Description
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Objectives:
To determine whether mental imagery can enhance walking ability and gait parameters in individuals with MS.
To measure the effect of mental simulation on muscle activity and walking patterns, including stride length, walking speed, and balance.
Study Procedure:
The study will consist of multiple sessions, where participants will first undergo baseline assessments of walking ability. Following this, they will engage in either the walking video and imagery task (experimental group) or the nature video viewing task (control group) for a predetermined period of time. Measurements of muscle activity using electromyography (EMG) and walking patterns will be recorded before and after the intervention.
Potential Impact:
The results from this study may provide insights into the use of mental practice techniques as a non-invasive intervention to improve mobility in individuals with MS, a population often affected by walking difficulties. Mental imagery could serve as an adjunct therapy to traditional physical rehabilitation methods.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
SINGLE
Study Groups
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Arm 1
Arm 1: Experimental Group: Action Observation + Motor Imagery
Action Observation + Motor Imagery
Participants will watch videos showing walking actions and will be instructed to mentally simulate the movement.
Arm 2
Arm 2: Control Group: Nature video
Nature Video
Participants will watch a video of nature scenes.
Interventions
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Action Observation + Motor Imagery
Participants will watch videos showing walking actions and will be instructed to mentally simulate the movement.
Nature Video
Participants will watch a video of nature scenes.
Eligibility Criteria
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Inclusion Criteria
* No history of relapse within the past 3 months and not currently experiencing a relapse
* A score of 24 or higher on the standardized Mini Mental State Examination
Exclusion Criteria
* History of other neurological disorders, head injury, or chronic psychiatric conditions
* Chronic pain lasting longer than six months
* Significant muscle stiffness in the legs that may affect EMG recordings
* Hearing difficulties
* Vision problems as determined by the Snellen visual acuity test
18 Years
ALL
No
Sponsors
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Hacettepe University
OTHER
Responsible Party
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Merve Ünal
Principal Investigator
Principal Investigators
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Yeliz Salcı, Assoc. Prof.
Role: STUDY_CHAIR
Hacettepe University
Locations
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Hacettepe University, Faculty of Physical Therapy and Rehabilitation
Ankara, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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References
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Wright DJ, Williams J, Holmes PS. Combined action observation and imagery facilitates corticospinal excitability. Front Hum Neurosci. 2014 Nov 27;8:951. doi: 10.3389/fnhum.2014.00951. eCollection 2014.
Rocca MA, Meani A, Fumagalli S, Pagani E, Gatti R, Martinelli-Boneschi F, Esposito F, Preziosa P, Cordani C, Comi G, Filippi M. Functional and structural plasticity following action observation training in multiple sclerosis. Mult Scler. 2019 Oct;25(11):1472-1487. doi: 10.1177/1352458518792771. Epub 2018 Aug 7.
Gil-Bermejo-Bernardez-Zerpa A, Moral-Munoz JA, Lucena-Anton D, Luque-Moreno C. Effectiveness of Motor Imagery on Motor Recovery in Patients with Multiple Sclerosis: Systematic Review. Int J Environ Res Public Health. 2021 Jan 9;18(2):498. doi: 10.3390/ijerph18020498.
Chye S, Valappil AC, Wright DJ, Frank C, Shearer DA, Tyler CJ, Diss CE, Mian OS, Tillin NA, Bruton AM. The effects of combined action observation and motor imagery on corticospinal excitability and movement outcomes: Two meta-analyses. Neurosci Biobehav Rev. 2022 Dec;143:104911. doi: 10.1016/j.neubiorev.2022.104911. Epub 2022 Nov 5.
Salamci M, Salci Y, Topuz S, Yalcin AI, Acar Ozen P, Tuncer A. Gait initiation in multiple sclerosis patients with and without functional loss. Mult Scler Relat Disord. 2023 Nov;79:104990. doi: 10.1016/j.msard.2023.104990. Epub 2023 Sep 4.
Other Identifiers
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FTREK25/48
Identifier Type: -
Identifier Source: org_study_id
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