Motor Imagery and Action Observation for Gait Function in MS

NCT ID: NCT07137624

Last Updated: 2025-09-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-15

Study Completion Date

2025-10-31

Brief Summary

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This study will investigate whether mentally simulating walking movements while watching others walk can improve walking performance in individuals with Multiple Sclerosis (MS). Participants will be divided into two groups: one group will watch walking videos and imagine themselves walking, while the other group will watch nature scenes. The study will measure muscle activity and walking patterns to assess the effects. The results may help support the use of mental practice techniques to improve mobility in people with MS.

Detailed Description

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This study aims to explore the impact of mental simulation of walking movements on walking performance in individuals with Multiple Sclerosis (MS). The participants will be randomly assigned to two groups: the experimental group will watch walking-related videos and engage in mental imagery exercises, imagining themselves walking, while the control group will watch nature scenes without any walking-related content.

Objectives:

To determine whether mental imagery can enhance walking ability and gait parameters in individuals with MS.

To measure the effect of mental simulation on muscle activity and walking patterns, including stride length, walking speed, and balance.

Study Procedure:

The study will consist of multiple sessions, where participants will first undergo baseline assessments of walking ability. Following this, they will engage in either the walking video and imagery task (experimental group) or the nature video viewing task (control group) for a predetermined period of time. Measurements of muscle activity using electromyography (EMG) and walking patterns will be recorded before and after the intervention.

Potential Impact:

The results from this study may provide insights into the use of mental practice techniques as a non-invasive intervention to improve mobility in individuals with MS, a population often affected by walking difficulties. Mental imagery could serve as an adjunct therapy to traditional physical rehabilitation methods.

Conditions

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Multiple Sclerosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participants will be randomly assigned to either the experimental group (motor imagery + action observation) or the control group (nature video).
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants
The study will be single-blinded. Participants will not be informed of their group assignment.

Study Groups

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Arm 1

Arm 1: Experimental Group: Action Observation + Motor Imagery

Group Type EXPERIMENTAL

Action Observation + Motor Imagery

Intervention Type BEHAVIORAL

Participants will watch videos showing walking actions and will be instructed to mentally simulate the movement.

Arm 2

Arm 2: Control Group: Nature video

Group Type OTHER

Nature Video

Intervention Type BEHAVIORAL

Participants will watch a video of nature scenes.

Interventions

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Action Observation + Motor Imagery

Participants will watch videos showing walking actions and will be instructed to mentally simulate the movement.

Intervention Type BEHAVIORAL

Nature Video

Participants will watch a video of nature scenes.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* A confirmed diagnosis of multiple sclerosis (MS) by a neurologist
* No history of relapse within the past 3 months and not currently experiencing a relapse
* A score of 24 or higher on the standardized Mini Mental State Examination

Exclusion Criteria

* Presence of serious health conditions affecting the muscles, heart, lungs, or metabolism that could interfere with participation
* History of other neurological disorders, head injury, or chronic psychiatric conditions
* Chronic pain lasting longer than six months
* Significant muscle stiffness in the legs that may affect EMG recordings
* Hearing difficulties
* Vision problems as determined by the Snellen visual acuity test
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hacettepe University

OTHER

Sponsor Role lead

Responsible Party

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Merve Ünal

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yeliz Salcı, Assoc. Prof.

Role: STUDY_CHAIR

Hacettepe University

Locations

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Hacettepe University, Faculty of Physical Therapy and Rehabilitation

Ankara, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Central Contacts

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Merve Ünal, Res. Asst.

Role: CONTACT

+905386582787

Facility Contacts

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Yeliz Salcı, Assoc. Prof.

Role: primary

03123243847

References

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Wright DJ, Williams J, Holmes PS. Combined action observation and imagery facilitates corticospinal excitability. Front Hum Neurosci. 2014 Nov 27;8:951. doi: 10.3389/fnhum.2014.00951. eCollection 2014.

Reference Type BACKGROUND
PMID: 25505880 (View on PubMed)

Rocca MA, Meani A, Fumagalli S, Pagani E, Gatti R, Martinelli-Boneschi F, Esposito F, Preziosa P, Cordani C, Comi G, Filippi M. Functional and structural plasticity following action observation training in multiple sclerosis. Mult Scler. 2019 Oct;25(11):1472-1487. doi: 10.1177/1352458518792771. Epub 2018 Aug 7.

Reference Type BACKGROUND
PMID: 30084706 (View on PubMed)

Gil-Bermejo-Bernardez-Zerpa A, Moral-Munoz JA, Lucena-Anton D, Luque-Moreno C. Effectiveness of Motor Imagery on Motor Recovery in Patients with Multiple Sclerosis: Systematic Review. Int J Environ Res Public Health. 2021 Jan 9;18(2):498. doi: 10.3390/ijerph18020498.

Reference Type BACKGROUND
PMID: 33435410 (View on PubMed)

Chye S, Valappil AC, Wright DJ, Frank C, Shearer DA, Tyler CJ, Diss CE, Mian OS, Tillin NA, Bruton AM. The effects of combined action observation and motor imagery on corticospinal excitability and movement outcomes: Two meta-analyses. Neurosci Biobehav Rev. 2022 Dec;143:104911. doi: 10.1016/j.neubiorev.2022.104911. Epub 2022 Nov 5.

Reference Type BACKGROUND
PMID: 36349570 (View on PubMed)

Salamci M, Salci Y, Topuz S, Yalcin AI, Acar Ozen P, Tuncer A. Gait initiation in multiple sclerosis patients with and without functional loss. Mult Scler Relat Disord. 2023 Nov;79:104990. doi: 10.1016/j.msard.2023.104990. Epub 2023 Sep 4.

Reference Type BACKGROUND
PMID: 37708821 (View on PubMed)

Other Identifiers

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FTREK25/48

Identifier Type: -

Identifier Source: org_study_id

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